zucapsaicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
analgesics, capsaicin analogues 4342 25775-90-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zucapsaicin
  • civamide
  • (Z)-Capsaicin
  • cis-Capsaicin
the cis-isomer of alkyl vanillylamide
  • Molecular weight: 305.42
  • Formula: C18H27NO3
  • CLOGP: 3.75
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.56
  • ALOGS: -4.56
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 54
kinase-selectivity-class ACVR2B,AXL,BRAF,CDK9,DDR1,EIF2AK3,EPHB4,GRK2,MAP2K6,SIK2,STK33,TEK 12
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M02AB02 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Capsaicin and similar agents
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent

Related Drugs by ATC class:

M02AB Capsaicin and similar agents 1 drug
capsaicin

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.64 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Transient receptor potential cation channel subfamily V member 1 Ion channel OPENER EC50 7.71 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D06388 KEGG_DRUG
C0763832 UMLSCUI
CHEBI:135952 CHEBI
CHEMBL313971 ChEMBL_ID
DB09120 DRUGBANK_ID
C117479 MESH_SUPPLEMENTAL_RECORD_UI
11576 IUPHAR_LIGAND_ID
7242 INN_ID
15OX67P384 UNII
1548942 PUBCHEM_CID
013914 NDDF
15OX67P384 INXIGHT DRUGS

Pharmaceutical products:

None