bunazosin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihypertensive substances, prazosin derivatives 429 80755-51-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bunazosin hydrochloride
  • detantol
  • bunazosin
  • bunazosin HCl
  • Molecular weight: 373.46
  • Formula: C19H27N5O3
  • CLOGP: 2.20
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 93.81
  • ALOGS: -2.81
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.34 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.72 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2 hours Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 0.44 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D058668 Adrenergic alpha-1 Receptor Antagonists
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Essential hypertension indication 59621000 DOID:10825




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.22 Basic
pKa2 0.87 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-1A adrenergic receptor GPCR ANTAGONIST WOMBAT-PK KEGG DRUG
Alpha-1B adrenergic receptor GPCR ANTAGONIST WOMBAT-PK KEGG DRUG
Alpha-2B adrenergic receptor GPCR WOMBAT-PK
Ribosyldihydronicotinamide dehydrogenase [quinone] Enzyme WOMBAT-PK

External reference:

IDSource
D01887 KEGG_DRUG
52712-76-2 SECONDARY_CAS_RN
19850 RXNORM
C0054222 UMLSCUI
CHEBI:31320 CHEBI
CHEMBL188185 ChEMBL_ID
DB12230 DRUGBANK_ID
C018176 MESH_SUPPLEMENTAL_RECORD_UI
2472 PUBCHEM_CID
5466 INN_ID
9UUW4V7G2H UNII
007091 NDDF
007092 NDDF

Pharmaceutical products:

None