sodium phosphate, monobasic 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4271 7558-80-7

Description:

MoleculeDescription

Synonyms:

  • sodium phosphate, monobasic
  • dihydrogen monosodium phosphate
  • phosphoric acid monosodium salt
  • monobasic sodium phosphate
  • monosodium dihydrogen orthophosphate
  • Molecular weight: 119.98
  • Formula: H2NaO4P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Analgesic therapy 81.59 24.57 15 3230 657 90624545
Antacid therapy 79.86 24.57 15 3230 739 90624463
Appendicolith 79.72 24.57 15 3230 746 90624456
Intestinal pseudo-obstruction 79.30 24.57 16 3229 1147 90624055
Drug therapy 78.81 24.57 15 3230 794 90624408
Anticoagulant therapy 78.66 24.57 15 3230 802 90624400
Encephalopathy 64.43 24.57 32 3213 46412 90578790
Blood phosphorus increased 58.43 24.57 16 3229 4302 90620900
Hyperphosphataemia 56.06 24.57 15 3230 3696 90621506
Aortic stenosis 52.36 24.57 16 3229 6320 90618882
Cytokine release syndrome 50.16 24.57 23 3222 27950 90597252
Blood uric acid increased 45.25 24.57 15 3230 7689 90617513
Activated partial thromboplastin time prolonged 45.02 24.57 15 3230 7810 90617392
End stage renal disease 43.68 24.57 15 3230 8556 90616646
Cardiogenic shock 43.49 24.57 20 3225 24448 90600754
Appendicitis 41.08 24.57 15 3230 10216 90614986
Anaemia 38.82 24.57 55 3190 352747 90272455
Blood calcium increased 38.68 24.57 15 3230 12043 90613159
Gout 33.83 24.57 15 3230 16844 90608358
Loss of bladder sensation 33.61 24.57 5 3240 57 90625145
Hyperlipidaemia 32.38 24.57 16 3229 22900 90602302
Bacterial infection 32.04 24.57 16 3229 23428 90601774
Febrile neutropenia 30.91 24.57 33 3212 158316 90466886
Blood creatinine increased 30.89 24.57 27 3218 101359 90523843
Mutism 30.78 24.57 8 3237 1761 90623441
Blood test abnormal 30.71 24.57 15 3230 20937 90604265
Hypophosphataemia 29.11 24.57 13 3232 14841 90610361
Sleep disorder therapy 29.08 24.57 6 3239 480 90624722
Ascites 28.51 24.57 19 3226 47721 90577481
Food refusal 27.48 24.57 6 3239 629 90624573
Condition aggravated 24.68 24.57 61 3184 595484 90029718

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 544.11 43.29 176 9388 13280 42598491
Appendicitis 481.62 43.29 179 9385 20434 42591337
Stress 388.53 43.29 192 9372 44020 42567751
Cardiogenic shock 377.56 43.29 176 9388 35464 42576307
Ventricular fibrillation 332.17 43.29 153 9411 29970 42581801
Ascites 313.85 43.29 181 9383 56497 42555274
Blood phosphorus increased 296.80 43.29 110 9454 12415 42599356
Abdominal distension 276.97 43.29 182 9382 71553 42540218
Myasthenia gravis 276.59 43.29 112 9452 16025 42595746
Multiple organ dysfunction syndrome 264.73 43.29 199 9365 96836 42514935
Hyponatraemia 261.22 43.29 201 9363 101261 42510510
Hyperphosphataemia 256.84 43.29 100 9464 12904 42598867
Hypophosphataemia 220.19 43.29 103 9461 20842 42590929
Incorrect route of product administration 202.66 43.29 102 9462 24203 42587568
Blood uric acid increased 196.68 43.29 87 9477 15460 42596311
General physical health deterioration 190.15 43.29 200 9364 151046 42460725
Sleep disorder therapy 187.25 43.29 67 9497 6827 42604944
Neuralgia 186.02 43.29 98 9466 25549 42586222
Bacterial infection 183.88 43.29 100 9464 27779 42583992
Drug therapy 180.84 43.29 64 9500 6316 42605455
Analgesic therapy 179.45 43.29 64 9500 6460 42605311
Sepsis 178.43 43.29 221 9343 199113 42412658
Blood cholesterol increased 171.04 43.29 94 9470 26647 42585124
Dry mouth 167.96 43.29 107 9457 39772 42571999
Iron deficiency 143.42 43.29 63 9501 10998 42600773
Abdominal pain 143.41 43.29 194 9370 190277 42421494
Anticoagulant therapy 130.44 43.29 46 9518 4489 42607282
Antacid therapy 128.67 43.29 46 9518 4671 42607100
Swelling 128.50 43.29 103 9461 54782 42556989
Sleep disorder 127.18 43.29 97 9467 47998 42563773
Diabetes mellitus 124.44 43.29 105 9459 59982 42551789
Activated partial thromboplastin time prolonged 121.63 43.29 63 9501 15840 42595931
Thrombosis 112.53 43.29 105 9459 68406 42543365
Intentional product misuse 109.70 43.29 99 9465 61801 42549970
Ulcer 102.88 43.29 57 9507 16384 42595387
End stage renal disease 102.51 43.29 57 9507 16501 42595270
Chronic obstructive pulmonary disease 100.32 43.29 95 9469 63019 42548752
Somnolence 98.90 43.29 139 9425 140966 42470805
Blood calcium increased 96.32 43.29 44 9520 8410 42603361
Troponin increased 89.88 43.29 55 9509 19007 42592764
Bronchopulmonary aspergillosis allergic 89.44 43.29 35 9529 4563 42607208
Aplastic anaemia 88.80 43.29 47 9517 12337 42599434
Vomiting 85.10 43.29 195 9369 289528 42322243
Drug intolerance 84.50 43.29 97 9467 80327 42531444
Hyperlipidaemia 83.77 43.29 55 9509 21461 42590310
Congenital hiatus hernia 82.72 43.29 36 9528 6138 42605633
Gout 79.47 43.29 59 9505 27996 42583775
Blood test abnormal 78.70 43.29 44 9520 12862 42598909
Bacteroides infection 73.47 43.29 26 9538 2561 42609210
Drug hypersensitivity 69.67 43.29 98 9466 99291 42512480
Pleuritic pain 68.76 43.29 33 9531 7044 42604727
Pulmonary embolism 68.15 43.29 107 9457 119505 42492266
Aortic stenosis 67.86 43.29 35 9529 8710 42603061
Micturition urgency 52.70 43.29 33 9531 11865 42599906
Total lung capacity decreased 51.71 43.29 22 9542 3548 42608223
Aspiration 51.50 43.29 38 9526 17848 42593923
Nausea 49.10 43.29 197 9367 396602 42215169
Breath sounds abnormal 47.26 43.29 31 9533 12062 42599709
Joint injury 46.39 43.29 33 9531 14643 42597128
Respiratory symptom 44.70 43.29 29 9535 11077 42600694
Condition aggravated 43.68 43.29 143 9421 260611 42351160

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 714.34 29.53 190 12644 14065 110562400
Appendicitis 596.79 29.53 193 12641 28271 110548194
Cardiogenic shock 471.71 29.53 195 12639 57143 110519322
Blood phosphorus increased 405.24 29.53 126 12708 16214 110560251
Ventricular fibrillation 403.46 29.53 159 12675 41154 110535311
Ascites 393.54 29.53 199 12635 92609 110483856
Stress 364.16 29.53 197 12637 105151 110471314
Hyperphosphataemia 359.19 29.53 115 12719 16266 110560199
Myasthenia gravis 340.01 29.53 118 12716 21393 110555072
Multiple organ dysfunction syndrome 319.68 29.53 206 12628 151504 110424961
Abdominal distension 283.53 29.53 202 12632 174901 110401564
Analgesic therapy 280.55 29.53 79 12755 7205 110569260
Drug therapy 280.47 29.53 79 12755 7212 110569253
Blood uric acid increased 279.23 29.53 102 12732 21427 110555038
Hypophosphataemia 276.55 29.53 114 12720 33068 110543397
Hyponatraemia 259.23 29.53 209 12625 217444 110359021
Sleep disorder therapy 251.69 29.53 73 12761 7398 110569067
Bacterial infection 246.86 29.53 116 12718 45920 110530545
Sepsis 245.72 29.53 242 12592 327104 110249361
Anticoagulant therapy 219.48 29.53 61 12773 5300 110571165
Antacid therapy 218.11 29.53 61 12773 5423 110571042
Neuralgia 211.24 29.53 106 12728 48372 110528093
Activated partial thromboplastin time prolonged 190.24 29.53 78 12756 22290 110554175
Incorrect route of product administration 188.84 29.53 108 12726 63953 110512512
End stage renal disease 172.86 29.53 72 12762 21401 110555064
Iron deficiency 172.84 29.53 69 12765 18407 110558058
Diabetes mellitus 170.72 29.53 119 12715 99262 110477203
General physical health deterioration 159.31 29.53 220 12614 425075 110151390
Thrombosis 150.00 29.53 114 12720 108548 110467917
Chronic obstructive pulmonary disease 142.97 29.53 111 12723 109047 110467418
Gout 141.98 29.53 74 12760 36492 110539973
Blood calcium increased 140.20 29.53 59 12775 17981 110558484
Hyperlipidaemia 134.77 29.53 71 12763 35777 110540688
Aortic stenosis 129.93 29.53 51 12783 13008 110563457
Abdominal pain 125.48 29.53 218 12616 512771 110063694
Troponin increased 123.51 29.53 63 12771 29703 110546762
Blood test abnormal 114.32 29.53 59 12775 28495 110547970
Aplastic anaemia 114.28 29.53 56 12778 24252 110552213
Intentional product misuse 114.06 29.53 106 12728 132798 110443667
Pulmonary embolism 111.89 29.53 131 12703 214343 110362122
Somnolence 111.38 29.53 154 12680 297295 110279170
Congenital hiatus hernia 109.21 29.53 37 12797 6222 110570243
Dry mouth 109.11 29.53 125 12709 199823 110376642
Ulcer 101.71 29.53 63 12771 43053 110533412
Bronchopulmonary aspergillosis allergic 98.46 29.53 37 12797 8389 110568076
Blood cholesterol increased 91.60 29.53 110 12724 184675 110391790
Bacteroides infection 87.22 29.53 26 12808 2893 110573572
Sleep disorder 77.51 29.53 105 12729 198539 110377926
Vomiting 75.28 29.53 254 12580 910421 109666044
Total lung capacity decreased 71.52 29.53 28 12806 7086 110569379
Pleuritic pain 66.47 29.53 34 12800 16106 110560359
Blood creatinine increased 65.83 29.53 93 12741 182796 110393669
Benign prostatic hyperplasia 65.36 29.53 35 12799 18199 110558266
Anaemia 63.37 29.53 172 12662 546914 110029551
Micturition urgency 60.73 29.53 34 12800 19286 110557179
Aspiration 60.55 29.53 40 12794 30493 110545972
Condition aggravated 58.01 29.53 202 12632 734634 109841831
Lung opacity 55.22 29.53 27 12807 11625 110564840
Respiratory symptom 54.45 29.53 29 12805 14916 110561549
Hypogonadism 52.02 29.53 16 12818 1978 110574487
Breath sounds abnormal 49.69 29.53 33 12801 25371 110551094
Arthralgia 48.74 29.53 15 12819 779617 109796848
Incision site pain 48.73 29.53 17 12817 3118 110573347
Intestinal pseudo-obstruction 47.60 29.53 17 12817 3339 110573126
Cytokine release syndrome 47.07 29.53 49 12785 70257 110506208
Malaise 43.68 29.53 12 12822 671807 109904658
Cardiovascular disorder 43.15 29.53 29 12805 22731 110553734
Dizziness 42.62 29.53 14 12820 698179 109878286
Swelling 42.21 29.53 112 12722 350929 110225536
Rash 41.24 29.53 22 12812 820942 109755523
Lymphocyte count decreased 40.31 29.53 41 12793 57202 110519263
Transaminases increased 38.57 29.53 42 12792 63348 110513117
Joint injury 38.38 29.53 34 12800 39960 110536505
Nasopharyngitis 34.66 29.53 3 12831 394358 110182107
Red blood cells urine positive 33.85 29.53 15 12819 5170 110571295
Peripheral swelling 33.11 29.53 4 12830 404030 110172435
Drug intolerance 33.05 29.53 113 12721 406399 110170066
Hypersensitivity 30.76 29.53 5 12829 403993 110172472
Fall 30.53 29.53 16 12818 603466 109972999
Pruritus 30.04 29.53 15 12819 581545 109994920

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypophosphatemia indication 4996001
Constipation indication 14760008 DOID:2089
Urinary tract infectious disease indication 68566005
Incomplete passage of stool indication 249515001
Calcium renal calculus indication 427649000
Osteopenia of prematurity off-label use 276703007
Fluid volume disorder contraindication 1860003
Anuria contraindication 2472002 DOID:2983
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Disorder of autonomic nervous system contraindication 15241006
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Hyperphosphatemia contraindication 20165001 DOID:0050459
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Toxic megacolon contraindication 28536002 DOID:1770
Hypovolemia contraindication 28560003
Atony of colon contraindication 29479008
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Hypovolemic shock contraindication 39419009
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Nephrocalcinosis contraindication 48638002 DOID:12679
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Gastrointestinal perforation contraindication 51875005
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Paralytic ileus contraindication 55525008 DOID:8442
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Colitis contraindication 64226004 DOID:0060180
Blood coagulation disorder contraindication 64779008 DOID:1247
Hyperparathyroidism contraindication 66999008 DOID:13543
Aortocoronary artery bypass graft contraindication 67166004
Esophagogastrostomy contraindication 70676003
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Oliguria contraindication 83128009
Hiatal hernia contraindication 84089009 DOID:12642
Cardiomyopathy contraindication 85898001 DOID:0050700
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Anemia due to enzyme deficiency contraindication 111577008
Prolonged QT interval contraindication 111975006
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Alcohol withdrawal syndrome contraindication 191480000
Decompensated cardiac failure contraindication 195111005
Acute constipation contraindication 197119006
Impaired renal function disorder contraindication 197663003
Imperforate anus contraindication 204731006 DOID:10488
Stapling of stomach contraindication 235245007
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Gastric retention contraindication 307227006
Congenital megacolon contraindication 360436002
Macrocolon contraindication 367495003
Ascites contraindication 389026000
Acute coronary syndrome contraindication 394659003
Cardiovascular event risk contraindication 395112001
Colostomy contraindication 398740003
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Myocardial infarction in recovery phase contraindication 418044006
Gastrointestinal hypomotility contraindication 421807004
Fever greater than 100.4 Fahrenheit contraindication 426000000
Congenital long QT syndrome contraindication 442917000
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000
Seizure due to Abrupt Benzodiazepine Withdrawal contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018072 VUID
N0000146412 NUI
4017619 VANDF
4018072 VANDF
C0770578 UMLSCUI
CHEBI:37585 CHEBI
CHEMBL1368 ChEMBL_ID
DB09449 DRUGBANK_ID
C018279 MESH_SUPPLEMENTAL_RECORD_UI
23672064 PUBCHEM_CID
235496 RXNORM
5208 MMSL
5469 MMSL
5474 MMSL
NOCODE MMSL
d01009 MMSL
d03095 MMSL
000761 NDDF
002336 NDDF
116124008 SNOMEDCT_US

Pharmaceutical products:

None