thymol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4258 89-83-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thymol
  • thyme camphor
  • thymol chrystals
A phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent.
  • Molecular weight: 150.22
  • Formula: C10H14O
  • CLOGP: 3.20
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -2.37
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D000935 Antifungal Agents
CHEBI has role CHEBI:27311 ethereal oil components

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.57 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Transient receptor potential cation channel subfamily A member 1 Ion channel EC50 5.22 CHEMBL
Transient receptor potential cation channel subfamily M member 8 Ion channel EC50 4.28 CHEMBL
Heat sensitive channel TRPV3 Unclassified EC50 4.54 CHEMBL

External reference:

IDSource
4019136 VUID
N0000147386 NUI
D01039 KEGG_DRUG
4019136 VANDF
C0040096 UMLSCUI
CHEBI:27607 CHEBI
IPB PDB_CHEM_ID
CHEMBL29411 ChEMBL_ID
D013943 MESH_DESCRIPTOR_UI
DB02513 DRUGBANK_ID
2499 IUPHAR_LIGAND_ID
3J50XA376E UNII
6989 PUBCHEM_CID
10553 RXNORM
NOCODE MMSL
002914 NDDF
331322007 SNOMEDCT_US
54932001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0363-0072 MOUTHWASH 0.06 kg ORAL OTC monograph not final 12 sections
Rinse HUMAN OTC DRUG LABEL 4 0363-0318 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Antispetic HUMAN OTC DRUG LABEL 4 0363-0664 MOUTHWASH 0.64 mg ORAL OTC monograph not final 14 sections
Tartar control plus HUMAN OTC DRUG LABEL 4 0363-0855 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Antiseptic HUMAN OTC DRUG LABEL 4 0869-0072 MOUTHWASH 0.64 mg ORAL OTC monograph not final 12 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0869-0318 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Tartar Control Plus HUMAN OTC DRUG LABEL 4 0869-0434 MOUTHWASH 0.64 mg ORAL OTC monograph not final 12 sections
Antispetic HUMAN OTC DRUG LABEL 4 0869-0664 MOUTHWASH 0.64 mg ORAL OTC monograph not final 12 sections
Antispetic HUMAN OTC DRUG LABEL 4 10202-664 MOUTHWASH 0.64 mg ORAL OTC monograph not final 11 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 11344-072 MOUTHWASH 0.06 kg ORAL OTC monograph not final 12 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 11344-318 MOUTHWASH 0.06 kg ORAL OTC monograph not final 13 sections
Antispetic HUMAN OTC DRUG LABEL 4 11344-567 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Antispetic HUMAN OTC DRUG LABEL 4 11673-072 MOUTHWASH 0.64 mg ORAL OTC monograph not final 12 sections
Antiseptic HUMAN OTC DRUG LABEL 4 11673-318 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Tartar control plus HUMAN OTC DRUG LABEL 4 11673-434 MOUTHWASH 0.64 mg ORAL OTC monograph not final 12 sections
Antispetic HUMAN OTC DRUG LABEL 4 11673-664 MOUTHWASH 0.64 mg ORAL OTC monograph not final 12 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 11822-0072 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Tartar control plus HUMAN OTC DRUG LABEL 4 11822-0434 MOUTHWASH 0.64 mg ORAL OTC monograph not final 10 sections
Antispetic HUMAN OTC DRUG LABEL 4 11822-0664 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Oral Care Antiseptic HUMAN OTC DRUG LABEL 4 11822-3108 MOUTHWASH 0.64 mg ORAL OTC monograph not final 12 sections
Tartar control plus HUMAN OTC DRUG LABEL 4 11822-5829 MOUTHWASH 0.64 mg ORAL OTC monograph not final 12 sections
Tartar Control Plus HUMAN OTC DRUG LABEL 4 11822-8787 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Antispetic HUMAN OTC DRUG LABEL 4 15127-318 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Mastic Dent HUMAN OTC DRUG LABEL 4 15304-4085 MOUTHWASH 0.64 mg ORAL OTC monograph not final 10 sections
Antispetic HUMAN OTC DRUG LABEL 4 21130-072 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 21130-318 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
Antispetic HUMAN OTC DRUG LABEL 4 21130-664 MOUTHWASH 0.64 mg ORAL OTC monograph not final 13 sections
CleanWell Natural Original Hand Sanitizer Wipes HUMAN OTC DRUG LABEL 1 28107-002 CLOTH 0.00 kg TOPICAL OTC monograph not final 7 sections
CleanWell Natural Orange Vanilla Hand Sanitizing Wipes HUMAN OTC DRUG LABEL 1 28107-007 CLOTH 0.00 kg TOPICAL OTC monograph not final 7 sections
CleanWell Natural Orange Vanilla Hand Sanitizer HUMAN OTC DRUG LABEL 1 28107-008 SPRAY 0.00 kg TOPICAL OTC monograph not final 7 sections