avobenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4242 70356-09-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • avobenzone
  • butylmethoxydibenzoylmethane
  • photoplex
causes allergic or photoallergic contact dermatitis; structure given in first source
  • Molecular weight: 310.39
  • Formula: C20H22O3
  • CLOGP: 4.68
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -5.70
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK 48
kinase-selectivity-class AXL,BRAF,DDR1,EIF2AK3,GRK2,PDK4 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1992 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 1192.98 27.23 327 7384 37643 90583093
Chronic sinusitis 469.10 27.23 143 7568 23659 90597077
Paraesthesia oral 428.97 27.23 143 7568 31516 90589220
Procedural pain 402.03 27.23 138 7573 33222 90587514
Vaginal flatulence 396.28 27.23 109 7602 12529 90608207
Female genital tract fistula 393.55 27.23 117 7594 17751 90602985
Radiculopathy 376.58 27.23 114 7597 18391 90602345
Proctitis 375.96 27.23 109 7602 15150 90605586
Vaginal discharge 349.78 27.23 109 7602 19355 90601381
Oral candidiasis 285.75 27.23 109 7602 35346 90585390
Haematochezia 239.71 27.23 118 7593 70795 90549941
Colitis ulcerative 236.17 27.23 111 7600 60155 90560581
Frequent bowel movements 235.93 27.23 109 7602 56826 90563910
Colitis 229.31 27.23 114 7597 69828 90550908
Rectal haemorrhage 222.49 27.23 118 7593 82626 90538110
Therapeutic product effect incomplete 207.73 27.23 154 7557 193742 90426994
Dyspepsia 172.06 27.23 139 7572 198021 90422715
Drug ineffective 150.32 27.23 348 7363 1383950 89236786
Constipation 111.60 27.23 128 7583 280267 90340469
Erythema 109.14 27.23 115 7596 229131 90391605
Weight decreased 108.83 27.23 147 7564 379763 90240973
Anaemia 95.69 27.23 133 7578 352669 90268067
Infusion related reaction 88.43 27.23 140 7571 416640 90204096
Pyrexia 82.07 27.23 176 7535 660309 89960427
Abdominal pain 77.19 27.23 128 7583 395593 90225143
Carbuncle 67.04 27.23 17 7694 1419 90619317
Malaise 63.52 27.23 148 7563 585838 90034898
Monoclonal immunoglobulin present 60.45 27.23 17 7694 2107 90618629
Hypothalamo-pituitary disorder 59.46 27.23 17 7694 2235 90618501
Amyloid arthropathy 50.34 27.23 14 7697 1666 90619070
Asthma-chronic obstructive pulmonary disease overlap syndrome 50.22 27.23 18 7693 4881 90615855
Total lung capacity increased 49.78 27.23 18 7693 5003 90615733
Overweight 46.85 27.23 18 7693 5916 90614820
Off label use 46.77 27.23 201 7510 1102051 89518685
Nasal polyps 45.51 27.23 21 7690 10859 90609877
Cholelithiasis 43.65 27.23 36 7675 52470 90568266
Fibrosis 43.26 27.23 17 7694 5935 90614801
Nausea 42.94 27.23 197 7514 1110119 89510617
Wrist deformity 41.28 27.23 14 7697 3224 90617512
Hypomania 39.81 27.23 18 7693 8879 90611857
Nephropathy 39.17 27.23 18 7693 9217 90611519
Jaundice cholestatic 37.73 27.23 18 7693 10025 90610711
Sarcoidosis 36.69 27.23 18 7693 10655 90610081
Renal cyst 36.22 27.23 19 7692 12931 90607805
Dyslipidaemia 34.61 27.23 17 7694 10090 90610646
Bronchiectasis 33.81 27.23 22 7689 22308 90598428
Body height decreased 31.92 27.23 17 7694 11932 90608804
Proctalgia 31.74 27.23 15 7696 8183 90612553
Rhinitis allergic 31.62 27.23 19 7692 16766 90603970
Pulmonary pain 31.61 27.23 13 7698 5101 90615635
Purpura 31.18 27.23 18 7693 14760 90605976
Schizophrenia 31.03 27.23 18 7693 14896 90605840
Fatigue 30.60 27.23 32 7679 1153991 89466745
Joint swelling 29.44 27.23 4 7707 503296 90117440
Pain 28.74 27.23 163 7548 996178 89624558
Bone density decreased 28.52 27.23 18 7693 17327 90603409
Cardiac murmur 27.73 27.23 18 7693 18176 90602560
Dyspnoea 27.43 27.23 21 7690 880934 89739802

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anal inflammation 162.11 23.69 34 2022 2195 42617084
SARS-CoV-2 test negative 151.96 23.69 31 2025 1744 42617535
Accident 125.91 23.69 34 2022 6469 42612810
Proctalgia 122.98 23.69 34 2022 7059 42612220
Haemorrhoids 89.82 23.69 33 2023 17064 42602215
Body temperature increased 87.76 23.69 34 2022 20324 42598955
Febrile neutropenia 45.35 23.69 50 2006 185653 42433626
Back pain 35.99 23.69 39 2017 141737 42477542
Chills 35.23 23.69 32 2024 94034 42525245
Pyrexia 33.21 23.69 64 1992 393978 42225301
Neutropenia 31.28 23.69 43 2013 199388 42419891
Vomiting 29.33 23.69 51 2005 289672 42329607
Pain 24.61 23.69 43 2013 244805 42374474

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 506.81 20.93 148 9090 21511 110558550
Chronic sinusitis 455.62 20.93 141 9097 24943 110555118
Paraesthesia oral 414.81 20.93 141 9097 33530 110546531
Female genital tract fistula 400.16 20.93 116 9122 16403 110563658
Vaginal flatulence 397.76 20.93 108 9130 12036 110568025
Procedural pain 387.97 20.93 136 9102 35429 110544632
Radiculopathy 369.30 20.93 113 9125 19223 110560838
Proctitis 362.29 20.93 108 9130 16819 110563242
Vaginal discharge 356.29 20.93 108 9130 17800 110562261
Oral candidiasis 259.57 20.93 108 9130 44652 110535409
Frequent bowel movements 214.26 20.93 109 9129 71281 110508780
Colitis ulcerative 208.84 20.93 110 9128 77253 110502808
Therapeutic product effect incomplete 192.56 20.93 155 9083 223650 110356411
Colitis 190.48 20.93 114 9124 102209 110477852
Rectal haemorrhage 188.74 20.93 120 9118 119713 110460348
Haematochezia 187.73 20.93 118 9120 115406 110464655
Dyspepsia 176.52 20.93 138 9100 190827 110389234
Anal inflammation 134.39 20.93 33 9205 2463 110577598
Proctalgia 134.27 20.93 48 9190 13174 110566887
SARS-CoV-2 test negative 123.73 20.93 30 9208 2123 110577938
Pyrexia 105.12 20.93 231 9007 898034 109682027
Constipation 103.64 20.93 138 9100 357648 110222413
Weight decreased 102.52 20.93 158 9080 467899 110112162
Infusion related reaction 101.30 20.93 141 9097 381021 110199040
Erythema 96.26 20.93 120 9118 291327 110288734
Malaise 89.11 20.93 182 9056 671637 109908424
Accident 86.29 20.93 33 9205 10919 110569142
Carbuncle 66.99 20.93 17 9221 1450 110578611
Anaemia 65.20 20.93 142 9096 546944 110033117
Pain 61.62 20.93 197 9041 954758 109625303
Abdominal pain 60.93 20.93 133 9105 512856 110067205
Monoclonal immunoglobulin present 57.75 20.93 17 9221 2523 110577538
Hypothalamo-pituitary disorder 55.84 20.93 17 9221 2829 110577232
Total lung capacity increased 53.56 20.93 19 9219 5093 110574968
Amyloid arthropathy 50.59 20.93 14 9224 1666 110578395
Asthma-chronic obstructive pulmonary disease overlap syndrome 49.56 20.93 19 9219 6325 110573736
Haemorrhoids 46.99 20.93 32 9206 35640 110544421
Overweight 45.68 20.93 18 9220 6446 110573615
Nasal polyps 44.98 20.93 22 9216 13178 110566883
Wrist deformity 41.74 20.93 14 9224 3175 110576886
Body temperature increased 40.87 20.93 35 9203 54678 110525383
Hypomania 40.84 20.93 19 9219 10191 110569870
Fibrosis 39.45 20.93 17 9221 7625 110572436
Nausea 38.75 20.93 204 9034 1235486 109344575
Cholelithiasis 38.33 20.93 36 9202 63386 110516675
Sarcoidosis 37.07 20.93 19 9219 12560 110567501
Rhinitis allergic 35.98 20.93 21 9217 17901 110562160
Jaundice cholestatic 34.40 20.93 19 9219 14589 110565472
Body height decreased 34.19 20.93 17 9221 10546 110569515
Renal cyst 30.55 20.93 19 9219 18153 110561908
Nephropathy 30.30 20.93 17 9221 13450 110566611
Bone density decreased 30.11 20.93 18 9220 16024 110564037
Pulmonary pain 29.24 20.93 13 9225 6280 110573781
Off label use 29.05 20.93 219 9019 1499966 109080095
Dyspnoea 28.91 20.93 30 9208 1106842 109473219
Bronchiectasis 28.60 20.93 24 9214 36469 110543592
Dyslipidaemia 27.62 20.93 17 9221 15948 110564113
Cardiac murmur 27.56 20.93 20 9218 24608 110555453
Schizophrenia 27.37 20.93 19 9219 21807 110558254
Joint swelling 26.52 20.93 3 9235 442842 110137219
Toxicity to various agents 24.80 20.93 5 9233 480550 110099511
Drug interaction 24.21 20.93 6 9232 500177 110079884
Therapeutic product effect delayed 23.24 20.93 10 9228 4469 110575592
Fatigue 22.68 20.93 42 9196 1215916 109364145
Headache 22.48 20.93 138 9100 882239 109697822
Death 21.77 20.93 16 9222 698853 109881208
Purpura 21.12 20.93 17 9221 24371 110555690

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003879 Dermatologic Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35610 antineoplastic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.94 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tyrosinase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
G63QQF2NOX UNII
4019467 VUID
N0000179319 NUI
D03015 KEGG_DRUG
4019467 VANDF
C0097513 UMLSCUI
CHEBI:134751 CHEBI
CHEMBL1200522 ChEMBL_ID
51040 PUBCHEM_CID
DB09495 DRUGBANK_ID
6480 INN_ID
C049935 MESH_SUPPLEMENTAL_RECORD_UI
C059933 MESH_SUPPLEMENTAL_RECORD_UI
45045 RXNORM
001976 NDDF
005097 NDDF
256171000 SNOMEDCT_US
422621002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.03 g TOPICAL OTC Monograph Drug 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.03 g TOPICAL OTC Monograph Drug 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.03 g TOPICAL OTC Monograph Drug 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.03 g TOPICAL OTC Monograph Drug 8 sections
SOLBAR THIRTY HUMAN OTC DRUG LABEL 5 0096-0689 GEL 30 mg TOPICAL OTC Monograph Drug 11 sections
SOLBAR SUNSCREEN 35 AVO HUMAN OTC DRUG LABEL 4 0096-0690 CREAM 30 mg TOPICAL OTC Monograph Drug 11 sections
SOLBAR SUNSCREEN 50 FIFTY HUMAN OTC DRUG LABEL 4 0096-0693 CREAM 10 mg TOPICAL OTC Monograph Drug 10 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.03 g TOPICAL OTC Monograph Drug 11 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.03 g TOPICAL OTC Monograph Drug 11 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.01 g TOPICAL OTC Monograph Drug 8 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.01 g TOPICAL OTC Monograph Drug 8 sections
Mederma Scar Cream HUMAN OTC DRUG LABEL 3 0113-4083 CREAM 30 mg TOPICAL OTC Monograph Drug 13 sections
Cetaphil HUMAN OTC DRUG LABEL 2 0299-3928 LOTION 3 g TOPICAL OTC Monograph Drug 10 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 28 mg TOPICAL OTC Monograph Drug 13 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 30 mg TOPICAL OTC Monograph Drug 13 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4133 LOTION 3 g TOPICAL OTC Monograph Drug 11 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4134 LOTION 3 g TOPICAL OTC Monograph Drug 10 sections
Cetaphil Healthy Renew Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4136 LOTION 28 mg TOPICAL OTC Monograph Drug 13 sections
Cetaphil Hydrating Face Sunscreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4142 LOTION 28 mg TOPICAL OTC Monograph Drug 13 sections
Walgreens SPF 70 Sport Continuous HUMAN OTC DRUG LABEL 4 0363-0035 SPRAY 30 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 55 Sheer Face Mist Sunscreen HUMAN OTC DRUG LABEL 4 0363-0053 SPRAY 300 mg TOPICAL OTC Monograph Drug 13 sections
Walgreens SPF 50 Clear Complexion Face Sunscreen HUMAN OTC DRUG LABEL 4 0363-0066 LOTION 27 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 30 Sport HUMAN OTC DRUG LABEL 4 0363-0093 LOTION 30 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 50 Sport Continuous Sunscreen HUMAN OTC DRUG LABEL 4 0363-0128 SPRAY 30 mg TOPICAL OTC Monograph Drug 12 sections
WALGREENS SPF 100 SHEER BODY SUNSCREEN MIST HUMAN OTC DRUG LABEL 4 0363-0135 AEROSOL, SPRAY 30 mg TOPICAL OTC Monograph Drug 13 sections
Walgreens SPF 50 Hydrating HUMAN OTC DRUG LABEL 4 0363-0136 LOTION 30 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 30 Hydrating HUMAN OTC DRUG LABEL 4 0363-0146 LOTION 27 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens Daily Facial Moisturizer with Broad Spectrum SPF 30 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0172 LOTION 30 mg TOPICAL OTC Monograph Drug 12 sections
WALGREENS 100 SHEER BROAD SPECTRUM SPF 100 HUMAN OTC DRUG LABEL 4 0363-0228 LOTION 30 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens 70 Hydrating Sport Broad Spectrum SPF 70 Sunscreen HUMAN OTC DRUG LABEL 4 0363-0251 LOTION 30 mg TOPICAL OTC Monograph Drug 12 sections