sodium lactate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4202 72-17-3

Description:

MoleculeDescription

Synonyms:

  • sodium lactate
  • lacolin
  • lactic acid sodium salt
  • monosodium lactate
The sodium salt of racemic or inactive lactic acid. It is a hygroscopic agent used intravenously as a systemic and urinary alkalizer.
  • Molecular weight: 112.06
  • Formula: C3H5NaO3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
March 22, 1971 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 899.89 33.48 425 3692 456126 90168204
Peritonitis bacterial 642.87 33.48 122 3995 5049 90619281
Peritonitis 480.30 33.48 122 3995 19583 90604747
Peritoneal dialysis complication 404.78 33.48 67 4050 1235 90623095
Fungal peritonitis 256.16 33.48 41 4076 605 90623725
Sepsis 209.46 33.48 119 3998 179695 90444635
Device interaction 192.40 33.48 28 4089 208 90624122
Encapsulating peritoneal sclerosis 107.58 33.48 18 4099 353 90623977
Ultrafiltration failure 98.64 33.48 16 4101 257 90624073
Cardiac arrest 84.59 33.48 55 4062 104880 90519450
Myocardial infarction 76.83 33.48 52 4065 105920 90518410
Cardiovascular disorder 72.13 33.48 26 4091 13466 90610864
Hypervolaemia 70.88 33.48 33 4084 32724 90591606
Cardiac disorder 69.61 33.48 39 4078 56833 90567497
Peritoneal cloudy effluent 68.70 33.48 12 4105 306 90624024
Cardiac failure 59.28 33.48 45 4072 109451 90514879
Cerebrovascular accident 58.71 33.48 47 4070 123486 90500844
Bloody peritoneal effluent 47.30 33.48 7 4110 59 90624271
Hypoglycaemia 45.23 33.48 32 4085 69816 90554514
Drug ineffective 43.19 33.48 6 4111 1384292 89240038
Gangrene 40.90 33.48 17 4100 12859 90611471
Marasmus 40.40 33.48 9 4108 814 90623516
Hypotension 34.93 33.48 57 4060 325340 90298990
Off label use 33.80 33.48 5 4112 1102247 89522083
Diabetic complication 33.64 33.48 8 4109 965 90623365

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peritonitis bacterial 836.54 28.18 190 5203 6725 42609217
Death 827.77 28.18 581 4812 470604 42145338
Peritonitis 523.74 28.18 161 5232 18472 42597470
Peritoneal dialysis complication 496.79 28.18 99 5294 1828 42614114
Fungal peritonitis 344.90 28.18 65 5328 880 42615062
Device interaction 150.24 28.18 30 5363 556 42615386
Myocardial infarction 136.75 28.18 118 5275 123891 42492051
Cardiac disorder 121.22 28.18 76 5317 48856 42567086
Encapsulating peritoneal sclerosis 119.56 28.18 25 5368 587 42615355
Cardiac failure 114.31 28.18 100 5293 106756 42509186
Gangrene 105.35 28.18 35 5358 5091 42610851
Ultrafiltration failure 104.38 28.18 20 5373 296 42615646
Cardiac arrest 98.64 28.18 93 5300 109227 42506715
Sepsis 85.46 28.18 115 5278 199219 42416723
Noninfectious peritonitis 83.34 28.18 15 5378 154 42615788
Hypervolaemia 78.35 28.18 44 5349 23081 42592861
Peritoneal cloudy effluent 76.17 28.18 16 5377 384 42615558
Cardiovascular disorder 60.94 28.18 31 5362 13334 42602608
Catheter site infection 59.17 28.18 20 5373 3063 42612879
Off label use 54.77 28.18 8 5385 638327 41977615
Bloody peritoneal effluent 48.95 28.18 9 5384 105 42615837
Drug ineffective 41.79 28.18 14 5379 630183 41985759
Peritoneal effluent abnormal 39.72 28.18 7 5386 63 42615879
Cerebrovascular accident 38.37 28.18 54 5339 97106 42518836
Hernia 37.29 28.18 21 5372 11052 42604890
Hypoglycaemia 34.24 28.18 40 5353 59814 42556128
Procedural pain 34.12 28.18 16 5377 5763 42610179
Blood glucose false positive 34.05 28.18 6 5387 54 42615888
Localised infection 32.17 28.18 24 5369 20349 42595593
Complication associated with device 31.92 28.18 16 5377 6665 42609277
Pneumonia 30.14 28.18 119 5274 422030 42193912
Peritoneal disorder 29.05 28.18 7 5386 316 42615626

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peritonitis bacterial 1196.23 25.19 239 6084 10294 110572682
Peritonitis 665.45 25.19 184 6139 32423 110550553
Death 569.57 25.19 399 5924 698470 109884506
Peritoneal dialysis complication 554.17 25.19 100 6223 2446 110580530
Fungal peritonitis 374.46 25.19 65 6258 1260 110581716
Device interaction 274.17 25.19 46 6277 721 110582255
Encapsulating peritoneal sclerosis 187.37 25.19 34 6289 854 110582122
Cardiac arrest 146.00 25.19 107 6216 196646 110386330
Sepsis 143.62 25.19 131 6192 327215 110255761
Ultrafiltration failure 108.31 25.19 19 6304 391 110582585
Myocardial infarction 102.42 25.19 86 6237 191997 110390979
Peritoneal cloudy effluent 98.16 25.19 19 6304 681 110582295
Gangrene 92.84 25.19 35 6288 16306 110566670
Noninfectious peritonitis 79.39 25.19 14 6309 297 110582679
Cardiac disorder 78.95 25.19 51 6272 76229 110506747
Hypervolaemia 71.58 25.19 41 6282 49419 110533557
Cardiac failure 64.88 25.19 66 6257 187560 110395416
Hypoglycaemia 63.91 25.19 53 6270 116051 110466925
Complication associated with device 62.65 25.19 28 6295 20045 110562931
Blood glucose false positive 60.87 25.19 9 6314 58 110582918
Bloody peritoneal effluent 58.92 25.19 10 6313 168 110582808
Catheter site infection 56.05 25.19 20 6303 7980 110574996
Off label use 52.63 25.19 11 6312 1500174 109082802
Drug ineffective 45.99 25.19 15 6308 1520525 109062451
Hypotension 41.50 25.19 92 6231 523757 110059219
Peritoneal effluent abnormal 39.90 25.19 6 6317 44 110582932
Peritoneal disorder 38.30 25.19 9 6314 817 110582159
Diabetic complication 38.21 25.19 10 6313 1412 110581564
Pneumonia 37.96 25.19 123 6200 876591 109706385
Haemodialysis 37.74 25.19 19 6304 17700 110565276
Cerebrovascular accident 36.05 25.19 48 6275 181236 110401740
Procedural complication 33.70 25.19 14 6309 8391 110574585
Abdominal distension 32.74 25.19 45 6278 175058 110407918
Blood loss anaemia 31.70 25.19 17 6306 18008 110564968
Arthralgia 28.76 25.19 5 6318 779627 109803349
Multimorbidity 28.27 25.19 8 6315 1512 110581464
Blood glucose increased 27.75 25.19 36 6287 132460 110450516
Blood albumin decreased 27.38 25.19 18 6305 27634 110555342
Headache 26.07 25.19 9 6314 882368 109700608
Rash pruritic 25.97 25.19 30 6293 98039 110484937
Mental status changes postoperative 25.20 25.19 5 6318 204 110582772

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:55324 gastrointestinal drug
CHEBI has role CHEBI:64049 food acidity regulator
CHEBI has role CHEBI:65255 food preservative
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:73336 vulnerary

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypokalemia indication 43339004
Hypokalemia Prevention indication
Brain damage contraindication 2470005
Anuria contraindication 2472002 DOID:2983
Tachyarrhythmia contraindication 6285003
Urinary tract obstruction contraindication 7163005 DOID:5200
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Myocardial infarction contraindication 22298006 DOID:5844
Ventricular tachycardia contraindication 25569003
Complete atrioventricular block contraindication 27885002
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Acidosis contraindication 51387008
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Ulcerative colitis contraindication 64766004 DOID:8577
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Arteriosclerotic vascular disease contraindication 72092001
Hyperchloremia contraindication 74450001
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Third degree burn injury contraindication 80247002
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Hiatal hernia contraindication 84089009 DOID:12642
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Gastrointestinal obstruction contraindication 126765001
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Myocardial dysfunction contraindication 233928007
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Drowsy contraindication 271782001
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Gastric ulcer contraindication 397825006 DOID:10808
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Hypertensive urgency contraindication 443482000
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018691 VUID
N0000147000 NUI
D02183 KEGG_DRUG
4018691 VANDF
C0142874 UMLSCUI
CHEMBL1357 ChEMBL_ID
D019354 MESH_DESCRIPTOR_UI
4157 INN_ID
TU7HW0W0QT UNII
23666456 PUBCHEM_CID
56489 RXNORM
1084 MMSL
5487 MMSL
d00469 MMSL
000750 NDDF
000760 NDDF
015438 NDDF
387306001 SNOMEDCT_US
55015008 SNOMEDCT_US
CHEBI:75228 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0264-2203 IRRIGANT 0.31 g IRRIGATION NDA 18 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0264-2203 IRRIGANT 0.31 g IRRIGATION NDA 18 sections
Lactated Ringers Irrigation HUMAN PRESCRIPTION DRUG LABEL 4 0264-7389 SOLUTION 310 mg IRRIGATION NDA 14 sections
Lactated Ringers Irrigation HUMAN PRESCRIPTION DRUG LABEL 4 0264-7389 SOLUTION 310 mg IRRIGATION NDA 14 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0264-7500 INJECTION, SOLUTION 0.31 g INTRAVENOUS NDA 24 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0264-7500 INJECTION, SOLUTION 0.31 g INTRAVENOUS NDA 24 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0264-7750 INJECTION, SOLUTION 0.31 g INTRAVENOUS NDA 26 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0264-7750 INJECTION, SOLUTION 0.31 g INTRAVENOUS NDA 26 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0264-7750 INJECTION, SOLUTION 0.31 g INTRAVENOUS NDA 26 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0264-7750 INJECTION, SOLUTION 0.31 g INTRAVENOUS NDA 26 sections
Dextrose in Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 5 0264-7751 INJECTION, SOLUTION 0.31 g INTRAVENOUS NDA 24 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0338-0114 IRRIGANT 310 mg IRRIGATION NDA 5 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0338-0114 IRRIGANT 310 mg IRRIGATION NDA 5 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0338-0117 INJECTION, SOLUTION 310 mg INTRAVENOUS NDA 26 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0338-0117 INJECTION, SOLUTION 310 mg INTRAVENOUS NDA 26 sections
Lactated Ringers and Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0338-0125 INJECTION, SOLUTION 310 mg INTRAVENOUS NDA 26 sections
Lactated Ringers and Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0338-0125 INJECTION, SOLUTION 310 mg INTRAVENOUS NDA 26 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0338-0137 IRRIGANT 3.10 g IRRIGATION NDA 17 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0338-0137 IRRIGANT 3.10 g IRRIGATION NDA 17 sections
Dextrose and Electrolyte No. 48 HUMAN PRESCRIPTION DRUG LABEL 6 0338-0143 INJECTION 260 mg INTRAVENOUS NDA 19 sections
Dextrose and Electrolyte No. 48 HUMAN PRESCRIPTION DRUG LABEL 6 0338-0143 INJECTION 260 mg INTRAVENOUS NDA 19 sections
Potassium Chloride in Lactated Ringers and Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0338-0811 INJECTION, SOLUTION 310 mg INTRAVENOUS NDA 26 sections
Potassium Chloride in Lactated Ringers and Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0338-0811 INJECTION, SOLUTION 310 mg INTRAVENOUS NDA 26 sections
DIANEAL Low Calcium with Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0941-0409 INJECTION, SOLUTION 448 mg INTRAPERITONEAL NDA 20 sections
DIANEAL Low Calcium with Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0941-0409 INJECTION, SOLUTION 448 mg INTRAPERITONEAL NDA 20 sections
DIANEAL PD-2 with Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0941-0411 INJECTION, SOLUTION 448 mg INTRAPERITONEAL NDA 20 sections
DIANEAL PD-2 with Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0941-0411 INJECTION, SOLUTION 448 mg INTRAPERITONEAL NDA 20 sections
DIANEAL PD-2 with Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0941-0413 INJECTION, SOLUTION 448 mg INTRAPERITONEAL NDA 20 sections
DIANEAL PD-2 with Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0941-0413 INJECTION, SOLUTION 448 mg INTRAPERITONEAL NDA 20 sections
DIANEAL PD-2 with Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0941-0415 INJECTION, SOLUTION 448 mg INTRAPERITONEAL NDA 20 sections