fingolimod 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
immunomodulators, both stimulant/suppressive and stimulant 4167 162359-55-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • FTY-720
  • fingolimod
  • fingolimod hydrochloride
  • gilenya
  • fingolimod HCl
A sphingosine-derivative and IMMUNOSUPPRESSIVE AGENT that blocks the migration and homing of LYMPHOCYTES to the CENTRAL NERVOUS SYSTEM through its action on SPHINGOSINE 1-PHOSPHATE RECEPTORS. It is used in the treatment of MULTIPLE SCLEROSIS.
  • Molecular weight: 307.48
  • Formula: C19H33NO2
  • CLOGP: 5.06
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 3
  • TPSA: 66.48
  • ALOGS: -4.65
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.50 mg O

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 17.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.53 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 144 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 95 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.950 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 41.976 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.188 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 10.814 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 0.050 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 0.470 % High 1
herg hERG pIC50 5.718 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 10.257 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.126 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 0.230 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 49
kinase-selectivity-class AKT2,AKT3,AXL,CAMK2D,CDK4,EIF2AK3,EPHB4,GRK2,INSR,PRKCD,STK33,TEK 12
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 5.035 Moderate 0.70
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 11.588 High 1
mh-clint Mouse hepatocyte intrinsic clearance 28.840 High 1
mppb Mouse plasma protein binding (% unbound) 0.100 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 16.982 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 0.360 % High 1
rat-kpuu-brain Rat brain Kpuu 0.173 % Moderate 0.70
rh-clint Rat hepatocyte intrinsic clearance 11.455 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 0.090 % High 1
rppb Rat plasma protein binding (% unbound) 0.160 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 1.803 uM High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 18, 2021 EMA MYLAN IRELAND LIMITED
Sept. 21, 2010 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 6202.72 13.12 2230 88993 50075 90487149
Lymphocyte count decreased 4957.66 13.12 1705 89518 33345 90503879
Central nervous system lesion 2793.89 13.12 847 90376 10799 90526425
Lymphopenia 2697.46 13.12 973 90250 21908 90515316
White blood cell count decreased 1554.30 13.12 1310 89913 165799 90371425
Expanded disability status scale score increased 1533.98 13.12 311 90912 512 90536712
Macular oedema 1112.69 13.12 342 90881 4567 90532657
Heart rate decreased 787.85 13.12 552 90671 52953 90484271
Vision blurred 705.60 13.12 702 90521 109591 90427633
Melanocytic naevus 695.79 13.12 243 90980 4943 90532281
Visual impairment 648.59 13.12 731 90492 131634 90405590
Optic neuritis 607.29 13.12 261 90962 9417 90527807
Off label use 601.43 13.12 183 91040 1102069 89435155
Gamma-glutamyltransferase increased 568.97 13.12 396 90827 37556 90499668
Rebound effect 546.16 13.12 240 90983 9144 90528080
JC polyomavirus test positive 545.29 13.12 157 91066 1645 90535579
Alanine aminotransferase increased 523.27 13.12 620 90603 117718 90419506
Fatigue 444.17 13.12 2306 88917 1151717 89385507
Gait disturbance 434.08 13.12 867 90356 259629 90277595
Hypoaesthesia 433.45 13.12 968 90255 313242 90223982
Multiple sclerosis 432.55 13.12 297 90926 27543 90509681
Balance disorder 409.97 13.12 497 90726 96583 90440641
Progressive multifocal leukoencephalopathy 389.22 13.12 225 90998 15430 90521794
Headache 388.92 13.12 1805 89418 860941 89676283
Breast cancer 365.49 13.12 354 90869 53407 90483817
Infusion related reaction 358.82 13.12 14 91209 416766 90120458
Ataxia 344.66 13.12 219 91004 17823 90519401
Hemiparesis 337.93 13.12 270 90953 31549 90505675
Atrioventricular block second degree 332.71 13.12 136 91087 4316 90532908
Atrioventricular block first degree 325.87 13.12 163 91060 8348 90528876
Muscular weakness 311.18 13.12 660 90563 206006 90331218
Systemic lupus erythematosus 308.62 13.12 13 91210 361883 90175341
Secondary progressive multiple sclerosis 303.44 13.12 97 91126 1482 90535742
Immune reconstitution inflammatory syndrome 303.32 13.12 146 91077 6873 90530351
Rheumatoid arthritis 302.79 13.12 15 91208 362599 90174625
Synovitis 302.42 13.12 6 91217 329746 90207478
Joint swelling 301.10 13.12 69 91154 503231 90033993
Micturition urgency 296.80 13.12 168 91055 11065 90526159
Herpes zoster 293.02 13.12 416 90807 94228 90442996
Arthropathy 291.03 13.12 20 91203 366222 90171002
Contraindicated product administered 288.98 13.12 7 91216 320132 90217092
Seborrhoeic keratosis 285.88 13.12 111 91112 3069 90534155
CD4 lymphocytes decreased 280.79 13.12 91 91132 1456 90535768
Glossodynia 279.65 13.12 10 91213 321769 90215455
Tumefactive multiple sclerosis 271.44 13.12 52 91171 51 90537173
Cognitive disorder 263.54 13.12 337 90886 69070 90468154
Drug hypersensitivity 262.83 13.12 71 91152 463538 90073686
Sensory disturbance 259.85 13.12 173 91050 15240 90521984
Bradycardia 258.74 13.12 368 90855 83479 90453745
Therapeutic product effect decreased 250.76 13.12 6 91217 277565 90259659
Eye pain 240.38 13.12 258 90965 43910 90493314
Toxicity to various agents 236.80 13.12 13 91210 287833 90249391
Drug ineffective 236.45 13.12 669 90554 1383629 89153595
Paraesthesia 235.23 13.12 667 90556 249659 90287565
Concomitant disease aggravated 233.00 13.12 145 91078 11373 90525851
Wound 230.92 13.12 20 91203 302960 90234264
Product use issue 230.46 13.12 30 91193 329889 90207335
Dizziness 228.08 13.12 1182 90041 588102 89949122
Limb discomfort 227.97 13.12 234 90989 37826 90499398
Swelling 219.68 13.12 74 91149 418984 90118240
Normal newborn 214.09 13.12 182 91041 23180 90514044
Basal cell carcinoma 212.25 13.12 212 91011 33177 90504047
Lentigo 211.97 13.12 60 91163 588 90536636
Prescribed underdose 209.31 13.12 314 90909 74705 90462519
Visual acuity reduced 207.65 13.12 179 91044 23231 90513993
Muscle spasticity 204.05 13.12 213 91010 35109 90502115
Aspartate aminotransferase increased 201.14 13.12 367 90856 102570 90434654
Acute kidney injury 199.44 13.12 40 91183 320347 90216877
Leukopenia 199.25 13.12 361 90862 100349 90436875
Blood alkaline phosphatase increased 197.73 13.12 243 90980 47836 90489388
Helicobacter infection 197.21 13.12 7 91216 226843 90310381
Haemangioma of skin 196.60 13.12 57 91166 613 90536611
Psoriatic arthropathy 195.24 13.12 8 91215 228327 90308897
Pericarditis 190.00 13.12 24 91199 270127 90267097
Stomatitis 182.44 13.12 29 91194 274669 90262555
Abortion spontaneous 181.28 13.12 247 90976 53809 90483415
Vertigo 178.99 13.12 281 90942 69530 90467694
Drug intolerance 177.75 13.12 116 91107 447475 90089749
Malignant melanoma 176.27 13.12 126 91097 12450 90524774
Meningitis cryptococcal 175.55 13.12 67 91156 1766 90535458
Rash 175.36 13.12 335 90888 795765 89741459
Death 173.73 13.12 124 91099 456427 90080797
Diplopia 167.37 13.12 174 91049 28540 90508684
Condition aggravated 166.88 13.12 213 91010 595332 89941892
Intentional product use issue 166.09 13.12 14 91209 216878 90320346
Hypersensitivity 164.63 13.12 130 91093 454547 90082677
High density lipoprotein increased 159.54 13.12 57 91166 1241 90535983
Muscle injury 158.80 13.12 4 91219 176650 90360574
Blood pressure decreased 157.79 13.12 276 90947 74619 90462605
Solar lentigo 157.14 13.12 55 91168 1125 90536099
Cervical dysplasia 156.61 13.12 78 91145 3956 90533268
Lymphocyte count increased 156.16 13.12 78 91145 3981 90533243
Pneumonia 155.33 13.12 252 90971 637807 89899417
Paraparesis 154.48 13.12 70 91153 2868 90534356
Lymphocyte count abnormal 152.29 13.12 50 91173 835 90536389
Folliculitis 151.62 13.12 15 91208 204338 90332886
Memory impairment 144.50 13.12 482 90741 196762 90340462
Oropharyngeal pain 143.09 13.12 341 90882 114846 90422378
Type 2 diabetes mellitus 143.02 13.12 18 91205 203226 90333998
Urinary incontinence 141.92 13.12 182 91041 37384 90499840
Urinary tract infection 141.52 13.12 646 90577 304986 90232238
Trigeminal neuralgia 140.36 13.12 73 91150 4058 90533166
Fibrous histiocytoma 139.64 13.12 43 91180 577 90536647
Cervix carcinoma 139.36 13.12 68 91155 3298 90533926
Back pain 139.22 13.12 660 90563 316515 90220709
Paresis 137.46 13.12 63 91160 2651 90534573
Palpitations 136.83 13.12 373 90850 136355 90400869
Lymphocyte percentage decreased 134.97 13.12 65 91158 3062 90534162
Aphasia 132.15 13.12 188 91035 42624 90494600
Stress 129.37 13.12 266 90957 81129 90456095
Sinus bradycardia 129.24 13.12 119 91104 16833 90520391
Fibromyalgia 127.79 13.12 26 91197 206243 90330981
Febrile neutropenia 127.58 13.12 8 91215 158341 90378883
Treatment failure 125.78 13.12 75 91148 303853 90233371
Dysarthria 125.60 13.12 209 91014 54273 90482951
Blister 123.49 13.12 51 91172 254947 90282277
Irritable bowel syndrome 122.74 13.12 29 91194 207419 90329805
Molluscum contagiosum 122.11 13.12 34 91189 312 90536912
Drug monitoring procedure not performed 121.61 13.12 41 91182 746 90536478
Low density lipoprotein increased 120.25 13.12 84 91139 8001 90529223
Impaired healing 119.77 13.12 43 91180 234156 90303068
Injury 117.92 13.12 27 91196 197322 90339902
Completed suicide 117.85 13.12 7 91216 145051 90392173
Discomfort 117.36 13.12 65 91158 274270 90262954
Fall 117.24 13.12 858 90365 480952 90056272
Peripheral swelling 116.36 13.12 147 91076 412959 90124265
Feeling abnormal 115.71 13.12 401 90822 166834 90370390
Wheezing 114.66 13.12 48 91175 238032 90299192
Vitamin D deficiency 114.39 13.12 113 91110 17443 90519781
Depression 113.82 13.12 600 90623 300001 90237223
Liver injury 113.22 13.12 18 91205 170549 90366675
Ill-defined disorder 113.09 13.12 24 91199 184867 90352357
Lower respiratory tract infection 112.22 13.12 56 91167 250603 90286621
Abdominal discomfort 110.98 13.12 194 91029 477134 90060090
Cryptococcal cutaneous infection 110.83 13.12 25 91198 84 90537140
C-reactive protein abnormal 110.48 13.12 4 91219 127425 90409799
Vomiting 108.98 13.12 417 90806 787876 89749348
Product use in unapproved indication 107.37 13.12 108 91115 336128 90201096
Joint range of motion decreased 105.93 13.12 8 91215 135635 90401589
Injection site pain 105.31 13.12 23 91200 173676 90363548
Blood alkaline phosphatase decreased 104.42 13.12 44 91179 1509 90535715
Neutrophil count increased 103.25 13.12 112 91111 19278 90517946
General physical health deterioration 102.47 13.12 124 91099 354991 90182233
Monocyte count increased 100.43 13.12 79 91144 9018 90528206
Osteoarthritis 99.97 13.12 36 91187 195694 90341530
Maternal exposure before pregnancy 99.96 13.12 86 91137 11127 90526097
Movement disorder 99.40 13.12 134 91089 28885 90508339
Skin lesion 99.37 13.12 153 91070 37212 90500012
Pruritus 99.13 13.12 252 90971 541273 89995951
Blood bilirubin decreased 98.66 13.12 37 91186 928 90536296
Urticaria 98.09 13.12 102 91121 312632 90224592
Cystoid macular oedema 97.81 13.12 46 91177 2054 90535170
Clumsiness 97.06 13.12 49 91174 2558 90534666
Therapeutic product effect incomplete 96.78 13.12 37 91186 193859 90343365
Oedema 95.45 13.12 41 91182 200254 90336970
Drug interaction 95.07 13.12 83 91140 276370 90260854
Expanded disability status scale 94.44 13.12 16 91207 0 90537224
Sensory loss 93.80 13.12 103 91120 17972 90519252
Speech disorder 93.42 13.12 166 91057 45419 90491805
Extensor plantar response 91.20 13.12 39 91184 1388 90535836
Diarrhoea 90.85 13.12 564 90659 938626 89598598
Demyelination 90.53 13.12 71 91152 8069 90529155
Arthralgia 90.33 13.12 440 90783 778082 89759142
Chest discomfort 89.86 13.12 325 90898 138040 90399184
Bursitis 89.41 13.12 13 91210 131641 90405583
Invasive ductal breast carcinoma 86.53 13.12 68 91155 7750 90529474
Adverse event 86.08 13.12 9 91214 117409 90419815
Dysplastic naevus 84.80 13.12 24 91199 235 90536989
Anaemia 84.13 13.12 141 91082 352661 90184563
Dysaesthesia 83.81 13.12 57 91166 5198 90532026
Gastrointestinal disorder 83.59 13.12 81 91142 256606 90280618
Cryptococcosis 83.57 13.12 37 91186 1434 90535790
Facet joint syndrome 82.25 13.12 4 91219 98385 90438839
Pulmonary fibrosis 82.10 13.12 7 91216 107496 90429728
Malignant neoplasm progression 81.50 13.12 7 91216 106863 90430361
Optic atrophy 81.46 13.12 37 91186 1524 90535700
Loss of personal independence in daily activities 80.54 13.12 19 91204 136086 90401138
CD8 lymphocytes decreased 80.00 13.12 22 91201 192 90537032
Maternal exposure during pregnancy 77.30 13.12 623 90600 359440 90177784
Exposure during pregnancy 76.74 13.12 76 91147 238334 90298890
Delivery 76.57 13.12 37 91186 1756 90535468
Gait spastic 76.22 13.12 23 91200 287 90536937
Depressed mood 76.12 13.12 161 91062 50061 90487163
Bladder dysfunction 76.09 13.12 32 91191 1092 90536132
Temperature intolerance 75.73 13.12 76 91147 11954 90525270
Hospitalisation 75.57 13.12 18 91205 128082 90409142
Prescribed overdose 75.54 13.12 6 91217 97619 90439605
Cryptococcal meningoencephalitis 75.28 13.12 20 91203 151 90537073
Ophthalmoplegia 74.41 13.12 36 91187 1713 90535511
Visual field defect 74.34 13.12 60 91163 7106 90530118
Neurogenic bladder 73.62 13.12 46 91177 3632 90533592
Magnetic resonance imaging abnormal 73.33 13.12 45 91178 3441 90533783
Seizure 73.06 13.12 326 90897 152303 90384921
Breast cancer stage III 72.01 13.12 3 91220 84444 90452780
Haemangioma 71.05 13.12 42 91181 3000 90534224
Immune thrombocytopenia 71.00 13.12 77 91146 13249 90523975
Knee arthroplasty 70.78 13.12 3 91220 83179 90454045
Superficial spreading melanoma stage unspecified 70.22 13.12 19 91204 155 90537069
Electrocardiogram PR prolongation 69.90 13.12 28 91195 842 90536382
T-lymphocyte count decreased 68.88 13.12 22 91201 335 90536889
Neuralgia 68.82 13.12 118 91105 31382 90505842
Cardiac failure congestive 68.77 13.12 9 91214 98685 90438539
Cafe au lait spots 68.77 13.12 13 91210 11 90537213
Asthma 68.29 13.12 86 91137 242074 90295150
Arthritis 68.17 13.12 42 91181 167273 90369951
JC virus infection 67.36 13.12 39 91184 2680 90534544
Decreased interest 66.04 13.12 46 91177 4361 90532863
Breast mass 65.65 13.12 63 91160 9384 90527840
Renal failure 65.36 13.12 25 91198 130982 90406242
Papilloma viral infection 64.90 13.12 33 91190 1749 90535475
CD4/CD8 ratio decreased 64.71 13.12 12 91211 8 90537216
Basophil count decreased 63.65 13.12 20 91203 288 90536936
Nystagmus 63.55 13.12 55 91168 7172 90530052
Gastrointestinal haemorrhage 63.44 13.12 8 91215 90240 90446984
Lung disorder 63.36 13.12 36 91187 149847 90387377
Delirium 62.88 13.12 14 91209 104345 90432879
Intentional product misuse 62.85 13.12 8 91215 89596 90447628
Incontinence 61.95 13.12 72 91151 13363 90523861
Injection site erythema 61.85 13.12 12 91211 98490 90438734
Band sensation 61.84 13.12 28 91195 1145 90536079
Actinic keratosis 61.62 13.12 39 91184 3149 90534075
Peroneal nerve palsy 61.48 13.12 49 91174 5699 90531525
Electrocardiogram abnormal 61.07 13.12 63 91160 10235 90526989
Hyponatraemia 61 13.12 29 91194 133509 90403715
Inflammation 60.91 13.12 54 91169 178538 90358686
Influenza like illness 60.75 13.12 199 91024 80412 90456812
Infection 60.54 13.12 176 91047 361918 90175306
Decreased immune responsiveness 60.15 13.12 58 91165 8690 90528534
Tremor 60.14 13.12 309 90914 152864 90384360
Peripheral venous disease 60.07 13.12 7 91216 83914 90453310
Skin cancer 59.92 13.12 71 91152 13448 90523776
Pleocytosis 59.35 13.12 26 91197 982 90536242
Ocular discomfort 59.12 13.12 50 91173 6320 90530904
Dysgraphia 58.86 13.12 40 91183 3643 90533581
Muscle tightness 58.61 13.12 70 91153 13369 90523855
Dizziness postural 58.47 13.12 58 91165 8995 90528229
Live birth 58.14 13.12 6 91217 79101 90458123
Monoparesis 58.13 13.12 32 91191 1995 90535229
Renal impairment 58.02 13.12 17 91206 105404 90431820
Burning sensation 57.44 13.12 167 91056 63285 90473939
Malignant melanoma in situ 56.90 13.12 25 91198 951 90536273
Drug abuse 56.21 13.12 8 91215 82339 90454885
Progressive multiple sclerosis 56.16 13.12 27 91196 1267 90535957
Pain 55.78 13.12 689 90534 995652 89541572
CSF protein increased 55.30 13.12 23 91200 763 90536461
Dysmetria 54.57 13.12 22 91201 673 90536551
Hypercholesterolaemia 54.21 13.12 17 91206 100875 90436349
White matter lesion 54.20 13.12 33 91190 2488 90534736
Medication error 53.81 13.12 10 91213 84642 90452582
Product quality issue 53.47 13.12 8 91215 79317 90457907
Aspartate aminotransferase decreased 53.29 13.12 24 91199 969 90536255
Obesity 52.85 13.12 20 91203 105487 90431737
Vitreous floaters 51.81 13.12 50 91173 7499 90529725
Hemianaesthesia 51.53 13.12 18 91205 366 90536858
Hepatic cirrhosis 51.52 13.12 3 91220 63250 90473974
Neutrophil percentage increased 51.32 13.12 34 91189 2969 90534255
Oxygen saturation decreased 51.19 13.12 22 91201 107461 90429763
Autoimmune disorder 51.13 13.12 8 91215 76736 90460488
Blindness 50.93 13.12 94 91129 26474 90510750
Adverse drug reaction 50.81 13.12 27 91196 116674 90420550
Coordination abnormal 50.65 13.12 83 91140 21273 90515951
Hypokinesia 50.01 13.12 70 91153 15627 90521597
JC polyomavirus test 49.71 13.12 11 91212 33 90537191
Intraductal proliferative breast lesion 49.32 13.12 35 91188 3418 90533806
Relapsing-remitting multiple sclerosis 48.32 13.12 21 91202 778 90536446
Relapsing multiple sclerosis 48.13 13.12 15 91208 210 90537014
Muscle spasms 47.73 13.12 424 90799 251459 90285765
Papule 47.54 13.12 49 91174 7953 90529271
Post herpetic neuralgia 47.35 13.12 31 91192 2653 90534571
Disturbance in attention 46.56 13.12 128 91095 46981 90490243
Sepsis 46.50 13.12 68 91155 179746 90357478
Squamous cell carcinoma 46.35 13.12 54 91169 10047 90527177
Blood pressure increased 45.99 13.12 348 90875 196869 90340355
Monocyte percentage increased 45.84 13.12 23 91200 1185 90536039
Skin papilloma 45.81 13.12 41 91182 5589 90531635
Paralysis 45.54 13.12 57 91166 11421 90525803
Septic shock 45.54 13.12 14 91209 84146 90453078
Adjustment disorder with depressed mood 45.30 13.12 3 91220 56750 90480474
Blood brain barrier defect 44.90 13.12 13 91210 139 90537085
Quadriplegia 44.90 13.12 28 91195 2203 90535021
Anaphylactic reaction 44.83 13.12 16 91207 87508 90449716
Lymphomatoid papulosis 44.82 13.12 13 91210 140 90537084
Thrombocytopenia 44.73 13.12 89 91134 208636 90328588
Pollakiuria 44.55 13.12 101 91122 32904 90504320
Human papilloma virus test positive 43.99 13.12 19 91204 693 90536531
Exposure via father 43.98 13.12 15 91208 283 90536941
Pancytopenia 43.92 13.12 34 91189 120229 90416995
Anogenital warts 43.77 13.12 18 91205 580 90536644
Maternal exposure timing unspecified 43.67 13.12 80 91143 22403 90514821
Injection site reaction 43.60 13.12 19 91204 92061 90445163
Hypotension 43.60 13.12 174 91049 325223 90212001
Influenza 43.38 13.12 264 90959 139000 90398224
Therapeutic response decreased 43.31 13.12 18 91205 89711 90447513
Rubella antibody positive 43.31 13.12 11 91212 68 90537156
Photophobia 42.99 13.12 77 91146 21192 90516032
Injection site swelling 42.80 13.12 5 91218 59834 90477390
Migraine 42.74 13.12 333 90890 190059 90347165
Wrong technique in product usage process 42.32 13.12 10 91213 71561 90465663
Psoriasis 42.13 13.12 52 91171 147702 90389522
Nail disorder 42.09 13.12 5 91218 59062 90478162
Bladder disorder 41.95 13.12 53 91170 10719 90526505
Urinary retention 41.81 13.12 107 91116 37637 90499587
Heart rate irregular 41.75 13.12 82 91141 24186 90513038
Quadriparesis 41.49 13.12 28 91195 2521 90534703
Hemiplegia 41.32 13.12 65 91158 16095 90521129
Concentric sclerosis 41.32 13.12 7 91216 0 90537224
Therapy non-responder 41.24 13.12 46 91177 136658 90400566
Gamma-glutamyltransferase decreased 41.17 13.12 15 91208 346 90536878
Decreased appetite 41.14 13.12 217 91006 376323 90160901
Injection site bruising 41.07 13.12 3 91220 52304 90484920
Cervix carcinoma stage 0 40.93 13.12 17 91206 562 90536662
Hypoglycaemia 40.82 13.12 10 91213 69838 90467386
Interstitial lung disease 40.82 13.12 13 91210 76392 90460832
Cardiac arrest 40.48 13.12 28 91195 104907 90432317
Deep vein thrombosis 40.18 13.12 21 91202 91599 90445625
C-reactive protein increased 40.03 13.12 76 91147 181313 90355911
Cerebral atrophy 39.89 13.12 38 91185 5608 90531616
Alanine aminotransferase decreased 39.79 13.12 19 91204 878 90536346
Injection site pruritus 39.78 13.12 4 91219 53830 90483394
Osteoporosis 39.63 13.12 24 91199 96507 90440717
Motor dysfunction 39.35 13.12 70 91153 19160 90518064
Neuropathy peripheral 39.27 13.12 48 91175 136922 90400302
Ophthalmic herpes zoster 39.22 13.12 28 91195 2760 90534464
Anaplastic large cell lymphoma T- and null-cell types 39.21 13.12 10 91213 63 90537161
Myelitis 39.12 13.12 25 91198 2053 90535171
Intentional overdose 38.99 13.12 23 91200 93811 90443413
Genital herpes 38.68 13.12 25 91198 2093 90535131
Acrochordon 38.60 13.12 22 91201 1467 90535757
Neuromyelitis optica spectrum disorder 38.59 13.12 22 91201 1468 90535756
Eosinophil count decreased 37.86 13.12 29 91194 3183 90534041
Lupus-like syndrome 37.79 13.12 3 91220 48843 90488381
Pain in extremity 37.34 13.12 649 90574 449880 90087344
Decreased vibratory sense 37.33 13.12 14 91209 351 90536873
Extra dose administered 37.33 13.12 46 91177 9072 90528152
Dry mouth 37.31 13.12 81 91142 183978 90353246
Eye disorder 37.17 13.12 84 91139 27306 90509918
Myelosuppression 37.06 13.12 5 91218 53586 90483638
Menstruation irregular 36.83 13.12 43 91180 8017 90529207
Lactic acidosis 36.64 13.12 4 91219 50459 90486765
Dysstasia 36.45 13.12 79 91144 24973 90512251
Mucosal inflammation 36.22 13.12 7 91216 57618 90479606
Red blood cell sedimentation rate increased 36.11 13.12 19 91204 82576 90454648
Extrasystoles 36.09 13.12 36 91187 5621 90531603
Anti-JC virus antibody index 35.41 13.12 6 91217 0 90537224
Janus kinase 2 mutation 35.41 13.12 6 91217 0 90537224
Asthenia 35.39 13.12 743 90480 533008 90004216
Partial seizures 35.31 13.12 40 91183 7220 90530004
Blood bilirubin increased 35.19 13.12 110 91113 43360 90493864
Cardiac failure 35.10 13.12 35 91188 109461 90427763
Hyperreflexia 34.65 13.12 38 91185 6619 90530605
CSF measles antibody positive 34.47 13.12 9 91214 63 90537161
Monoplegia 34.43 13.12 29 91194 3645 90533579
Anxiety 34.40 13.12 469 90754 309303 90227921
Non-cardiac chest pain 34.35 13.12 38 91185 6683 90530541
Brain stem syndrome 34.15 13.12 16 91207 708 90536516
Grip strength decreased 34.02 13.12 26 91197 92550 90444674
Sleep disorder 33.99 13.12 95 91128 197935 90339289
Photopsia 33.96 13.12 33 91190 4991 90532233
International normalised ratio increased 33.73 13.12 4 91219 47312 90489912
Taste disorder 33.73 13.12 10 91213 61536 90475688
Neoplasm progression 33.68 13.12 3 91220 44483 90492741
Cerebellar syndrome 33.10 13.12 29 91194 3843 90533381
Gastrooesophageal reflux disease 33.06 13.12 74 91149 166263 90370961
Night sweats 32.98 13.12 49 91174 128717 90408507
Squamous cell carcinoma of skin 32.81 13.12 39 91184 7410 90529814
Drug ineffective for unapproved indication 32.77 13.12 13 91210 66631 90470593
Supraventricular extrasystoles 32.70 13.12 33 91190 5224 90532000
Maculopathy 32.59 13.12 24 91199 2482 90534742
Macular fibrosis 32.48 13.12 13 91210 390 90536834
Respiratory failure 32.39 13.12 43 91180 118375 90418849
Facial paralysis 32.37 13.12 57 91166 15477 90521747
Overdose 32.30 13.12 69 91154 157640 90379584
Vulval cancer 32.11 13.12 16 91207 812 90536412
Herpes zoster cutaneous disseminated 31.99 13.12 11 91212 213 90537011
Accidental exposure to product 31.69 13.12 3 91220 42363 90494861
Sebaceous hyperplasia 31.63 13.12 7 91216 21 90537203
Retinal cyst 31.45 13.12 9 91214 92 90537132
Pulmonary embolism 31.40 13.12 52 91171 130768 90406456
Mitral valve atresia 31.39 13.12 7 91216 22 90537202
Varicella virus test positive 31.15 13.12 10 91213 155 90537069
Fluid retention 30.79 13.12 26 91197 88065 90449159
Visual acuity tests abnormal 30.74 13.12 10 91213 162 90537062
Hypokalaemia 30.66 13.12 53 91170 131063 90406161
Pleural effusion 30.29 13.12 41 91182 111950 90425274
Macular cyst 30.08 13.12 7 91216 28 90537196
Personality change 30.08 13.12 37 91186 7284 90529940
Retinal vein occlusion 29.96 13.12 23 91200 2533 90534691
Cardio-respiratory arrest 29.94 13.12 13 91210 63127 90474097
Acne 29.72 13.12 79 91144 28428 90508796
Chronic kidney disease 29.70 13.12 7 91216 50184 90487040
Mood altered 29.58 13.12 58 91165 17086 90520138
Melanocytic hyperplasia 29.51 13.12 5 91218 0 90537224
Exposure via partner 29.28 13.12 9 91214 120 90537104
Colitis ulcerative 29.23 13.12 12 91211 60254 90476970
Hypocalcaemia 29.19 13.12 4 91219 42364 90494860
JC virus CSF test positive 29.15 13.12 7 91216 33 90537191
Dyspepsia 29.11 13.12 102 91121 198058 90339166
Herpes virus infection 29.08 13.12 34 91189 6350 90530874
Pregnancy 29.06 13.12 13 91210 62034 90475190
Metabolic acidosis 28.82 13.12 10 91213 55666 90481558
Sinus arrhythmia 28.69 13.12 18 91205 1431 90535793
Rhabdomyolysis 28.69 13.12 8 91215 51248 90485976
Lower limb fracture 28.62 13.12 26 91197 84987 90452237
Transient tachypnoea of the newborn 28.24 13.12 9 91214 136 90537088
Ventricular extrasystoles 28.11 13.12 49 91174 13201 90524023
Chronic obstructive pulmonary disease 28.08 13.12 20 91203 73809 90463415
Multiple organ dysfunction syndrome 28.04 13.12 17 91206 68319 90468905
Erythema 27.97 13.12 127 91096 229119 90308105
Hemiparaesthesia 27.48 13.12 9 91214 149 90537075
Ovarian cancer 27.48 13.12 34 91189 6733 90530491
Colour blindness 27.39 13.12 11 91212 333 90536891
Treatment noncompliance 27.28 13.12 9 91214 51718 90485506
Varicella zoster virus infection 27.21 13.12 26 91197 3851 90533373
Vaginal dysplasia 27.11 13.12 8 91215 92 90537132
Organic brain syndrome 27.08 13.12 10 91213 240 90536984
Rectal haemorrhage 27.04 13.12 26 91197 82718 90454506
Bronchial carcinoma 26.87 13.12 14 91209 781 90536443
Uterine leiomyoma 26.82 13.12 43 91180 10821 90526403
Dehydration 26.65 13.12 103 91120 194344 90342880
Sciatica 26.53 13.12 38 91185 101344 90435880
Vaccination failure 26.39 13.12 16 91207 1197 90536027
Urge incontinence 26.32 13.12 16 91207 1203 90536021
Haematocrit increased 26.21 13.12 23 91200 3055 90534169
Metamorphopsia 26.12 13.12 17 91206 1440 90535784
Dysphagia 26.08 13.12 198 91025 112080 90425144
Abortion 26.06 13.12 22 91201 2773 90534451
Adenocarcinoma of colon 25.99 13.12 22 91201 2784 90534440
Abnormal sensation in eye 25.91 13.12 19 91204 1952 90535272
Somnolence 25.89 13.12 323 90900 208761 90328463
Focal dyscognitive seizures 25.79 13.12 23 91200 3121 90534103
Hypoxia 25.76 13.12 21 91202 72378 90464846
Electrocardiogram PR shortened 25.66 13.12 12 91211 529 90536695
Retinal oedema 25.51 13.12 15 91208 1061 90536163
Hyperkalaemia 25.50 13.12 17 91206 64947 90472277
Monocyte count decreased 25.42 13.12 21 91202 2570 90534654
Blindness unilateral 25.39 13.12 35 91188 7701 90529523
Walking aid user 25.31 13.12 3 91220 35503 90501721
Colitis 25.25 13.12 20 91203 69922 90467302
Exostosis 25.10 13.12 11 91212 53123 90484101
Joint stiffness 24.95 13.12 25 91198 78017 90459207
Tinea versicolour 24.92 13.12 8 91215 124 90537100
Unevaluable event 24.90 13.12 12 91211 54836 90482388
Coeliac disease 24.90 13.12 7 91216 44603 90492621
Ligament sprain 24.71 13.12 49 91174 14550 90522674
Tinea pedis 24.70 13.12 17 91206 1580 90535644
Dyspnoea 24.63 13.12 687 90536 880268 89656956
Pneumonitis 24.53 13.12 7 91216 44163 90493061
Panic attack 24.44 13.12 70 91153 26295 90510929
Sedation 24.34 13.12 9 91214 48162 90489062
Foot deformity 24.25 13.12 15 91208 59636 90477588
Angioedema 24.12 13.12 18 91205 64858 90472366
Retinal aneurysm 24.10 13.12 9 91214 223 90537001
Respiratory disorder 24.08 13.12 18 91205 64798 90472426
CD4 lymphocytes abnormal 23.77 13.12 6 91217 36 90537188
Blindness transient 23.76 13.12 26 91197 4517 90532707
Presbyopia 23.74 13.12 12 91211 628 90536596
Borderline glaucoma 23.71 13.12 5 91218 11 90537213
Bicuspid aortic valve 23.71 13.12 8 91215 146 90537078
Haemorrhagic adrenal infarction 23.63 13.12 6 91217 37 90537187
Gastrointestinal carcinoma 23.63 13.12 19 91204 2238 90534986
Saccadic eye movement 23.60 13.12 7 91216 82 90537142
Haematochezia 23.50 13.12 22 91201 70891 90466333
Loss of consciousness 23.49 13.12 230 90993 140008 90397216
Blood chloride increased 23.43 13.12 22 91201 3188 90534036
Eye movement disorder 23.36 13.12 30 91193 6168 90531056
Mean cell haemoglobin increased 23.36 13.12 24 91199 3881 90533343
Surgery 23.34 13.12 8 91215 44879 90492345
Muscle fatigue 23.21 13.12 21 91202 2903 90534321
Head discomfort 23.18 13.12 51 91172 16282 90520942
Milia 23.16 13.12 8 91215 157 90537067
Hypertonic bladder 22.94 13.12 25 91198 4323 90532901
Abdominal pain upper 22.94 13.12 219 91004 332455 90204769
Progressive relapsing multiple sclerosis 22.74 13.12 6 91217 44 90537180
Electrocardiogram T wave abnormal 22.72 13.12 20 91203 2668 90534556
Spinal cord disorder 22.67 13.12 16 91207 1549 90535675
Tongue biting 22.42 13.12 18 91205 2115 90535109
Melaena 22.35 13.12 4 91219 34793 90502431
Pyramidal tract syndrome 22.27 13.12 11 91212 548 90536676
Drug tolerance decreased 22.21 13.12 3 91220 32127 90505097
Benign neoplasm of skin 22.19 13.12 8 91215 179 90537045
Hypoglossal nerve paralysis 22.12 13.12 5 91218 17 90537207
Oral herpes 21.96 13.12 79 91144 33445 90503779
Retinal disorder 21.91 13.12 17 91206 1902 90535322
Herpes zoster meningoencephalitis 21.90 13.12 10 91213 417 90536807
Macular pigmentation 21.90 13.12 5 91218 18 90537206
Eye naevus 21.90 13.12 5 91218 18 90537206
Protein total decreased 21.68 13.12 31 91192 7058 90530166
Disability 21.64 13.12 7 91216 40738 90496486
Central nervous system inflammation 21.62 13.12 8 91215 193 90537031
Thyroid cancer 21.49 13.12 29 91194 6255 90530969
Neoplasm malignant 21.48 13.12 79 91144 33801 90503423
Endometrial adenocarcinoma 21.41 13.12 15 91208 1435 90535789
Mobility decreased 21.38 13.12 156 91067 250578 90286646
Rash pruritic 21.33 13.12 31 91192 82183 90455041
Asthenopia 21.33 13.12 20 91203 2894 90534330
Seborrhoeic dermatitis 21.31 13.12 16 91207 1704 90535520
Intervertebral disc protrusion 21.26 13.12 68 91155 27128 90510096
Nervousness 21.25 13.12 79 91144 33977 90503247
Papillary thyroid cancer 21.12 13.12 19 91204 2608 90534616
Hepatic cytolysis 21.11 13.12 3 91220 30913 90506311
Neurocryptococcosis 21.10 13.12 5 91218 22 90537202
Multiple lentigines syndrome 21.10 13.12 8 91215 207 90537017
Liver function test abnormal 20.94 13.12 104 91119 50741 90486483
Frequent bowel movements 20.90 13.12 16 91207 56919 90480305
Feeling cold 20.86 13.12 68 91155 27397 90509827
Lymphogranuloma venereum 20.84 13.12 4 91219 4 90537220
Drug eruption 20.82 13.12 5 91218 35402 90501822
Disease recurrence 20.76 13.12 84 91139 37569 90499655
CD30 expression 20.74 13.12 6 91217 64 90537160
Drug resistance 20.68 13.12 3 91220 30446 90506778
Breast discomfort 20.67 13.12 11 91212 641 90536583
Amenorrhoea 20.64 13.12 40 91183 11682 90525542
Atrioventricular block 20.55 13.12 34 91189 8781 90528443
Enchondromatosis 20.43 13.12 7 91216 134 90537090
Status epilepticus 20.38 13.12 53 91170 18821 90518403
Hemianopia homonymous 20.35 13.12 12 91211 853 90536371
Romberg test positive 20.27 13.12 8 91215 231 90536993
Dysuria 20.24 13.12 86 91137 39315 90497909
Cervix disorder 20.22 13.12 11 91212 670 90536554
Rash maculo-papular 20.10 13.12 8 91215 40925 90496299
Thunderclap headache 20.08 13.12 9 91214 359 90536865
Anal incontinence 20.08 13.12 48 91175 16182 90521042
Fine motor skill dysfunction 20.06 13.12 26 91197 5393 90531831
Smear cervix abnormal 20.05 13.12 20 91203 3122 90534102
Spinal cord injury 20.03 13.12 13 91210 1096 90536128
Sinusitis 19.95 13.12 235 90988 342853 90194371
Cranial nerve disorder 19.83 13.12 11 91212 696 90536528
Hypercalcaemia 19.82 13.12 5 91218 34235 90502989
Weight increased 19.67 13.12 299 90924 417628 90119596
Magnetic resonance imaging head abnormal 19.59 13.12 18 91205 2538 90534686
Migraine with aura 19.56 13.12 20 91203 3216 90534008
Viral infection 19.45 13.12 88 91135 41326 90495898
Haematemesis 19.38 13.12 5 91218 33721 90503503
Anti-actin antibody positive 19.22 13.12 4 91219 8 90537216
Cystitis 19.22 13.12 124 91099 66594 90470630
Hyperglycaemia 19.13 13.12 14 91209 50956 90486268
Hypomagnesaemia 19.11 13.12 6 91217 35582 90501642
Vertigo positional 19.01 13.12 20 91203 3324 90533900
Drug-induced liver injury 18.92 13.12 39 91184 90279 90446945
Vibration test abnormal 18.91 13.12 5 91218 37 90537187
Diabetic retinal oedema 18.91 13.12 9 91214 413 90536811
Retinal haemorrhage 18.80 13.12 26 91197 5738 90531486
White blood cell count increased 18.78 13.12 124 91099 67117 90470107
Thrombosis 18.63 13.12 28 91195 73223 90464001
Heavy menstrual bleeding 18.54 13.12 54 91169 20476 90516748
Rash erythematous 18.46 13.12 23 91200 65081 90472143
Bundle branch block right 18.40 13.12 25 91198 5428 90531796
Fear-related avoidance of activities 18.36 13.12 7 91216 184 90537040
Restless legs syndrome 18.31 13.12 57 91166 22413 90514811
Refraction disorder 18.28 13.12 6 91217 100 90537124
Pulmonary hypertension 18.27 13.12 10 91213 42513 90494711
Eye haemorrhage 18.24 13.12 35 91188 10145 90527079
Heart rate abnormal 18.09 13.12 26 91197 5945 90531279
Bone marrow failure 18.09 13.12 5 91218 32216 90505008
Enzyme level abnormal 18.05 13.12 8 91215 311 90536913
Optic nerve injury 18.04 13.12 10 91213 632 90536592
Facial paresis 17.87 13.12 21 91202 3942 90533282
Polycythaemia vera 17.84 13.12 7 91216 199 90537025
Tinea infection 17.84 13.12 13 91210 1323 90535901
Hepatitis E 17.82 13.12 15 91208 1884 90535340
Precancerous lesion of digestive tract 17.71 13.12 3 91220 0 90537224
Hemihyperaesthesia 17.71 13.12 3 91220 0 90537224
Hypoplastic left heart syndrome 17.68 13.12 7 91216 204 90537020
Hepatic failure 17.57 13.12 9 91214 39719 90497505
Pulmonary oedema 17.53 13.12 22 91201 62058 90475166
Immunodeficiency 17.50 13.12 88 91135 43146 90494078
Product measured potency issue 17.41 13.12 6 91217 117 90537107
Oedema peripheral 17.26 13.12 171 91052 257744 90279480
Glaucoma 17.24 13.12 53 91170 20702 90516522
Breast cancer stage II 17.19 13.12 7 91216 35327 90501897
Large for dates baby 17.14 13.12 9 91214 510 90536714
Keratosis pilaris 17.13 13.12 6 91217 123 90537101
Cerebellar ataxia 17.13 13.12 11 91212 911 90536313
Upper respiratory tract infection 17.08 13.12 201 91022 128117 90409107
Macule 17.05 13.12 17 91206 2652 90534572
Rosacea 17.05 13.12 25 91198 5822 90531402
Lymphadenopathy 17.02 13.12 91 91132 45684 90491540
Plasma cell myeloma 16.97 13.12 10 91213 40818 90496406
Vulval cancer stage 0 16.95 13.12 6 91217 127 90537097
Chromaturia 16.88 13.12 50 91173 19137 90518087
Meningioma 16.73 13.12 23 91200 5048 90532176
Herpes zoster infection neurological 16.70 13.12 9 91214 538 90536686
Lepromatous leprosy 16.63 13.12 4 91219 19 90537205
Hemianopia 16.62 13.12 15 91208 2067 90535157
Lung adenocarcinoma 16.52 13.12 24 91199 5541 90531683
Crying 16.43 13.12 60 91163 25585 90511639
Blood creatinine increased 16.39 13.12 50 91173 101336 90435888
Reflexes abnormal 16.36 13.12 10 91213 759 90536465
Facial pain 16.32 13.12 39 91184 13143 90524081
Urinary hesitation 16.32 13.12 16 91207 2447 90534777
Autoimmune haemolytic anaemia 16.26 13.12 24 91199 5621 90531603
Haematocrit decreased 16.13 13.12 84 91139 41748 90495476
Herpes simplex meningitis 16.11 13.12 5 91218 69 90537155
Cerebral disorder 16.10 13.12 24 91199 5670 90531554
Cerebral artery stenosis 16.05 13.12 9 91214 582 90536642
Invasive lobular breast carcinoma 16.03 13.12 11 91212 1018 90536206
Hypoaesthesia oral 16.02 13.12 43 91180 15557 90521667
Back injury 16 13.12 14 91209 46608 90490616
Nervous system disorder 15.98 13.12 53 91170 21540 90515684
Chest pain 15.94 13.12 428 90795 319217 90218007
Breast neoplasm 15.90 13.12 13 91210 1567 90535657
Nasal sinus cancer 15.85 13.12 4 91219 24 90537200
Musculoskeletal stiffness 15.77 13.12 207 91016 296325 90240899
Solar dermatitis 15.76 13.12 6 91217 157 90537067
Electroencephalogram abnormal 15.71 13.12 20 91203 4076 90533148
Chest wall mass 15.70 13.12 9 91214 607 90536617
Uveitis 15.50 13.12 43 91180 15860 90521364
Bladder discomfort 15.49 13.12 10 91213 836 90536388
Sopor 15.47 13.12 3 91220 24641 90512583
Intention tremor 15.44 13.12 8 91215 441 90536783
Vitamin D decreased 15.44 13.12 36 91187 11943 90525281
Neuroendocrine carcinoma of the skin 15.36 13.12 10 91213 848 90536376
Carcinoid crisis 15.35 13.12 7 91216 291 90536933
Lip squamous cell carcinoma 15.35 13.12 6 91217 169 90537055
Optic disc disorder 15.32 13.12 4 91219 28 90537196
Vertigo CNS origin 15.32 13.12 4 91219 28 90537196
Diabetic ketoacidosis 15.26 13.12 3 91220 24404 90512820
Adenocarcinoma gastric 15.26 13.12 9 91214 640 90536584
Visceral leishmaniasis 15.26 13.12 9 91214 640 90536584
Shock 15.19 13.12 5 91218 28773 90508451
HER2 positive breast cancer 15.10 13.12 8 91215 462 90536762
Mediastinal abscess 15.08 13.12 4 91219 30 90537194
Emotional disorder 15.07 13.12 41 91182 14956 90522268
Disease progression 15.06 13.12 94 91129 156521 90380703
Injection site rash 15.06 13.12 3 91220 24170 90513054
Blood creatinine decreased 15.02 13.12 25 91198 6490 90530734
Arrhythmia 14.96 13.12 83 91140 42249 90494975
Tonic clonic movements 14.93 13.12 13 91210 1709 90535515
Bladder pain 14.90 13.12 16 91207 2721 90534503
Amnesia 14.90 13.12 171 91052 108334 90428890
Phaeohyphomycosis 14.89 13.12 8 91215 475 90536749
Neurological decompensation 14.88 13.12 18 91205 3483 90533741
Epilepsy 14.84 13.12 137 91086 82069 90455155
Mental fatigue 14.82 13.12 9 91214 675 90536549
Pulmonary arterial hypertension 14.82 13.12 4 91219 26183 90511041
Infection susceptibility increased 14.79 13.12 19 91204 3907 90533317
Electrocardiogram QT prolonged 14.76 13.12 124 91099 72332 90464892
Central nervous system immune reconstitution inflammatory response 14.74 13.12 4 91219 33 90537191
Anti-thyroid antibody positive 14.72 13.12 8 91215 486 90536738
Retinal exudates 14.68 13.12 9 91214 687 90536537
B-lymphocyte count decreased 14.61 13.12 12 91211 1457 90535767
Invasive breast carcinoma 14.54 13.12 10 91213 929 90536295
Immune system disorder 14.50 13.12 35 91188 11870 90525354
Skin exfoliation 14.50 13.12 29 91194 67884 90469340
Glioblastoma 14.50 13.12 10 91213 933 90536291
Congenital megacolon 14.42 13.12 3 91220 6 90537218
Cerebral thrombosis 14.41 13.12 13 91210 1790 90535434
Swollen tongue 14.37 13.12 15 91208 45941 90491283
Herpes zoster reactivation 14.37 13.12 6 91217 201 90537023
Product substitution error 14.34 13.12 4 91219 37 90537187
Red blood cell count increased 14.31 13.12 18 91205 3625 90533599
Essential thrombocythaemia 14.29 13.12 6 91217 204 90537020
Cataract subcapsular 14.27 13.12 9 91214 722 90536502
Muscle rigidity 14.26 13.12 39 91184 14270 90522954
Uterine cancer 14.24 13.12 22 91201 5363 90531861
Incorrect dose administered 14.18 13.12 37 91186 78893 90458331
Upper motor neurone lesion 14.15 13.12 6 91217 209 90537015
Vaccination error 14.10 13.12 3 91220 7 90537217
Persistent depressive disorder 14.06 13.12 11 91212 1246 90535978
Optic nerve disorder 14.05 13.12 11 91212 1247 90535977
Blood albumin decreased 14.04 13.12 43 91180 16760 90520464
Dyschromatopsia 13.98 13.12 9 91214 748 90536476
Skin ulcer 13.88 13.12 18 91205 50057 90487167
Ulcer 13.74 13.12 8 91215 32874 90504350
Pityriasis rosea 13.74 13.12 5 91218 115 90537109
Facial spasm 13.70 13.12 9 91214 775 90536449
Tension headache 13.68 13.12 26 91197 7483 90529741
Cutaneous T-cell lymphoma 13.58 13.12 12 91211 1608 90535616
Herpes simplex 13.57 13.12 31 91192 10150 90527074
Zika virus infection 13.56 13.12 3 91220 9 90537215
Rectal cancer 13.51 13.12 14 91209 2287 90534937
Atrial fibrillation 13.48 13.12 79 91144 133532 90403692
Tandem gait test abnormal 13.47 13.12 4 91219 47 90537177
Acute respiratory distress syndrome 13.45 13.12 6 91217 28680 90508544
Adenocarcinoma of the cervix 13.42 13.12 6 91217 238 90536986
Generalised tonic-clonic seizure 13.40 13.12 70 91153 34833 90502391
Fear 13.39 13.12 42 91181 16580 90520644
Cytomegalovirus infection 13.39 13.12 5 91218 26597 90510627
Anembryonic gestation 13.37 13.12 8 91215 584 90536640
Malignant melanoma stage I 13.32 13.12 4 91219 49 90537175
Postmature baby 13.31 13.12 5 91218 126 90537098
Swelling face 13.24 13.12 40 91183 81312 90455912
Injection site mass 13.23 13.12 3 91220 22087 90515137
Transaminases increased 13.19 13.12 73 91150 37119 90500105
Squamous cell carcinoma of the cervix 13.18 13.12 7 91216 406 90536818
Depressed level of consciousness 13.17 13.12 34 91189 72750 90464474
Immunosuppression 13.13 13.12 34 91189 12043 90525181

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 2251.49 16.44 664 24559 13600 42582512
Lymphocyte count decreased 1183.59 16.44 487 24736 27322 42568790
Central nervous system lesion 869.03 16.44 279 24944 7591 42588521
Lymphopenia 671.15 16.44 303 24920 21260 42574852
Expanded disability status scale score increased 637.26 16.44 124 25099 330 42595782
Macular oedema 363.12 16.44 119 25104 3450 42592662
Alanine aminotransferase increased 361.67 16.44 346 24877 88060 42508052
Gait disturbance 285.91 16.44 320 24903 97680 42498432
Gamma-glutamyltransferase increased 278.88 16.44 196 25027 32301 42563811
White blood cell count decreased 240.79 16.44 311 24912 110085 42486027
JC polyomavirus test positive 229.83 16.44 63 25160 968 42595144
Heart rate decreased 225.73 16.44 181 25042 36351 42559761
Visual impairment 221.57 16.44 192 25031 42921 42553191
Hypoaesthesia 199.10 16.44 228 24995 71235 42524877
Secondary progressive multiple sclerosis 189.45 16.44 45 25178 373 42595739
Vision blurred 187.45 16.44 193 25030 53506 42542606
Multiple sclerosis 187.33 16.44 91 25132 7507 42588605
Off label use 186.63 16.44 73 25150 638262 41957850
Balance disorder 184.20 16.44 181 25042 47464 42548648
Acute kidney injury 163.10 16.44 15 25208 367322 42228790
Muscular weakness 158.54 16.44 220 25003 83278 42512834
Muscle spasticity 154.16 16.44 77 25146 6745 42589367
Aspartate aminotransferase increased 147.51 16.44 204 25019 76959 42519153
Optic neuritis 147.31 16.44 64 25159 4078 42592034
Melanocytic naevus 146.20 16.44 58 25165 2934 42593178
Prescribed underdose 140.09 16.44 83 25140 10199 42585913
Hepatic enzyme increased 134.09 16.44 150 25073 45634 42550478
Fatigue 130.91 16.44 556 24667 435085 42161027
Tumefactive multiple sclerosis 121.75 16.44 23 25200 49 42596063
Paraesthesia 115.34 16.44 177 25046 73282 42522830
Headache 111.86 16.44 353 24870 239016 42357096
Progressive multifocal leukoencephalopathy 109.27 16.44 74 25149 11462 42584650
Memory impairment 105.38 16.44 139 25084 50083 42546029
Death 98.49 16.44 81 25142 471104 42125008
Herpes zoster 98.10 16.44 118 25105 38759 42557353
Febrile neutropenia 96.32 16.44 3 25220 185700 42410412
Rebound effect 93.86 16.44 57 25166 7322 42588790
Depression 90.53 16.44 202 25021 111161 42484951
Ataxia 89.26 16.44 75 25148 16050 42580062
Toxicity to various agents 87.87 16.44 15 25208 229121 42366991
Anaemia 84.94 16.44 30 25193 280248 42315864
Osseous cryptococcosis 83.63 16.44 13 25210 0 42596112
Paraparesis 83.57 16.44 35 25188 2036 42594076
Cognitive disorder 80.19 16.44 100 25123 34072 42562040
Basal cell carcinoma 79.76 16.44 82 25141 22651 42573461
Hypotension 77.32 16.44 28 25195 257603 42338509
Drug interaction 76.84 16.44 31 25192 266968 42329144
Sensory disturbance 76.09 16.44 49 25174 6974 42589138
Bradycardia 75.06 16.44 160 25063 85324 42510788
Limb discomfort 74.02 16.44 61 25162 12706 42583406
Movement disorder 68.52 16.44 62 25161 14636 42581476
Meningitis cryptococcal 68.16 16.44 35 25188 3248 42592864
Seborrhoeic keratosis 66.62 16.44 28 25195 1643 42594469
Visual acuity reduced 66.50 16.44 66 25157 17484 42578628
Lymphocyte percentage decreased 64.68 16.44 30 25193 2229 42593883
Hemiparesis 63.36 16.44 64 25159 17312 42578800
Malignant melanoma 61.04 16.44 48 25175 9352 42586760
Diplopia 60.18 16.44 67 25156 20249 42575863
Concomitant disease aggravated 59.41 16.44 41 25182 6545 42589567
Depressed mood 57.37 16.44 70 25153 23314 42572798
Drug monitoring procedure not performed 57.05 16.44 18 25205 460 42595652
Magnetic resonance imaging abnormal 55.53 16.44 25 25198 1733 42594379
Sinus bradycardia 54.69 16.44 55 25168 14798 42581314
Decreased vibratory sense 54.31 16.44 17 25206 423 42595689
Visceral leishmaniasis 51.64 16.44 21 25202 1133 42594979
Dysarthria 51.62 16.44 88 25135 39719 42556393
CD4 lymphocytes decreased 50.34 16.44 24 25199 1897 42594215
Drug ineffective 50.19 16.44 198 25025 629999 41966113
Low density lipoprotein increased 49.87 16.44 34 25189 5321 42590791
Hyponatraemia 48.12 16.44 3 25220 101459 42494653
Vitamin D deficiency 47.69 16.44 39 25184 8034 42588078
Liver function test increased 47.66 16.44 59 25164 19939 42576173
Paresis 47.21 16.44 25 25198 2471 42593641
Eye pain 46.76 16.44 54 25169 16976 42579136
Immune reconstitution inflammatory syndrome 45.74 16.44 42 25181 10101 42586011
Multiple organ dysfunction syndrome 45.63 16.44 3 25220 97032 42499080
Decreased immune responsiveness 45.22 16.44 23 25200 2092 42594020
Thrombocytopenia 44.40 16.44 29 25194 190250 42405862
Coordination abnormal 43.63 16.44 37 25186 8013 42588099
Immunodeficiency 42.60 16.44 35 25188 7255 42588857
Oropharyngeal pain 42.50 16.44 84 25139 42426 42553686
Atrioventricular block second degree 42.39 16.44 28 25195 4159 42591953
Trigeminal neuralgia 42.33 16.44 20 25203 1549 42594563
Progressive multiple sclerosis 40.48 16.44 12 25211 247 42595865
Micturition urgency 40.07 16.44 42 25181 11856 42584256
Drug abuse 39.79 16.44 7 25216 104764 42491348
Blood alkaline phosphatase decreased 39.71 16.44 17 25206 1044 42595068
Pneumonia 39.28 16.44 124 25099 422025 42174087
Dizziness 39.22 16.44 267 24956 248987 42347125
Demyelination 39.16 16.44 25 25198 3504 42592608
Cardiac failure 38.76 16.44 8 25215 106848 42489264
Pancytopenia 38.44 16.44 11 25212 117732 42478380
Diarrhoea 38.39 16.44 142 25081 460707 42135405
Overdose 37.93 16.44 8 25215 105256 42490856
Renal failure 37.66 16.44 19 25204 143707 42452405
Relapsing-remitting multiple sclerosis 37.12 16.44 18 25205 1477 42594635
Cystoid macular oedema 36.85 16.44 16 25207 1017 42595095
Sensory loss 36.80 16.44 28 25195 5196 42590916
Blood cholesterol increased 35.83 16.44 60 25163 26681 42569431
Dehydration 35.30 16.44 20 25203 141747 42454365
Bladder dysfunction 35.20 16.44 12 25211 393 42595719
Anogenital warts 35.04 16.44 14 25209 721 42595391
Drug hypersensitivity 34.91 16.44 8 25215 99381 42496731
Vaccination failure 34.39 16.44 17 25206 1455 42594657
Blood alkaline phosphatase increased 34.32 16.44 67 25156 33530 42562582
Visual field defect 33.76 16.44 26 25197 4912 42591200
Hyperkalaemia 33.75 16.44 4 25219 80454 42515658
Squamous cell carcinoma 33.70 16.44 40 25183 12942 42583170
Lymphocyte count increased 33.63 16.44 24 25199 4040 42592072
Motor dysfunction 33.41 16.44 32 25191 8114 42587998
Septic shock 32.96 16.44 7 25216 91665 42504447
Interstitial lung disease 32.66 16.44 4 25219 78458 42517654
Neutrophil percentage increased 32.48 16.44 18 25205 1947 42594165
Urinary incontinence 32.26 16.44 51 25172 21617 42574495
Cryptococcosis 31.36 16.44 21 25202 3190 42592922
Renal impairment 31.32 16.44 13 25210 110215 42485897
Leiomyosarcoma 31.09 16.44 9 25214 170 42595942
Bladder disorder 30.96 16.44 22 25201 3677 42592435
Aphasia 30.89 16.44 53 25170 24030 42572082
High density lipoprotein increased 30.71 16.44 11 25212 418 42595694
Monocyte count increased 30.51 16.44 26 25197 5668 42590444
Skin lesion 29.98 16.44 56 25167 27118 42568994
Cardiac failure congestive 29.84 16.44 7 25216 85595 42510517
Urinary tract infection 29.74 16.44 127 25096 99157 42496955
Mobility decreased 29.70 16.44 65 25158 35241 42560871
Molluscum contagiosum 28.79 16.44 10 25213 347 42595765
Therapeutic product effect incomplete 28.61 16.44 4 25219 70935 42525177
CD4/CD8 ratio decreased 28.57 16.44 6 25217 26 42596086
Condition aggravated 28.33 16.44 71 25152 260683 42335429
Nasopharyngitis 27.96 16.44 111 25112 83885 42512227
Respiratory failure 27.93 16.44 21 25202 128111 42468001
Sepsis 27.81 16.44 47 25176 199287 42396825
Gait inability 27.66 16.44 49 25174 22784 42573328
Neurogenic bladder 27.56 16.44 17 25206 2243 42593869
Monkeypox 27.34 16.44 10 25213 404 42595708
Muscle spasms 27.28 16.44 112 25111 85932 42510180
Hypokalaemia 26.78 16.44 5 25218 71716 42524396
Back pain 26.02 16.44 158 25065 141618 42454494
Expanded disability status scale 25.73 16.44 4 25219 0 42596112
Atrioventricular block first degree 25.68 16.44 25 25198 6466 42589646
Ophthalmoplegia 25.45 16.44 16 25207 2184 42593928
Blood creatinine increased 25.32 16.44 17 25206 109986 42486126
Haemangioma of skin 25.26 16.44 8 25215 207 42595905
Platelet count decreased 25.07 16.44 27 25196 138554 42457558
Hypoglycaemia 25.04 16.44 3 25220 59851 42536261
White matter lesion 24.73 16.44 12 25211 986 42595126
Neuropathy peripheral 24.45 16.44 15 25208 101838 42494274
Cardio-respiratory arrest 24.38 16.44 3 25220 58633 42537479
Electrocardiogram abnormal 24.28 16.44 30 25193 10115 42585997
Rhabdomyolysis 24.18 16.44 8 25215 78011 42518101
Monocyte percentage increased 24.10 16.44 12 25211 1043 42595069
Gastrointestinal haemorrhage 24.01 16.44 14 25209 97712 42498400
Exposure via father 23.80 16.44 7 25216 140 42595972
Intentional product misuse 23.80 16.44 4 25219 61896 42534216
Hypoxia 23.75 16.44 6 25217 69780 42526332
Infusion related reaction 23.22 16.44 4 25219 60802 42535310
T-lymphocyte count decreased 22.94 16.44 8 25215 281 42595831
Cryptococcal cutaneous infection 22.84 16.44 7 25216 162 42595950
Neutropenia 22.68 16.44 53 25170 199378 42396734
Hospitalisation 22.38 16.44 8 25215 74322 42521790
Testicular seminoma (pure) stage I 22.31 16.44 5 25218 31 42596081
Feeling abnormal 22.24 16.44 91 25132 69695 42526417
Acrochordon 22.17 16.44 9 25214 483 42595629
Upper motor neurone lesion 22.14 16.44 7 25216 180 42595932
Quadriparesis 22.07 16.44 15 25208 2335 42593777
Testicular necrosis 21.69 16.44 4 25219 7 42596105
Pulmonary oedema 21.49 16.44 3 25220 53269 42542843
Cryptococcal meningoencephalitis 21.34 16.44 7 25216 203 42595909
Fibrous histiocytoma 21.31 16.44 8 25215 348 42595764
Urobilinogen urine increased 21.24 16.44 8 25215 351 42595761
Intentional product use issue 21.17 16.44 8 25215 71825 42524287
Pleural effusion 21.07 16.44 16 25207 97150 42498962
Peroneal nerve palsy 20.85 16.44 17 25206 3485 42592627
Peripheral swelling 20.70 16.44 14 25209 90256 42505856
Lentigo 20.58 16.44 10 25213 824 42595288
Hepatobiliary disease 20.45 16.44 9 25214 591 42595521
Temperature intolerance 19.99 16.44 19 25204 4769 42591343
Neutrophil count increased 19.62 16.44 39 25184 19765 42576347
Romberg test positive 19.61 16.44 5 25218 57 42596055
Dysdiadochokinesis 19.54 16.44 7 25216 266 42595846
Haemangioma 19.43 16.44 13 25210 1972 42594140
Gamma-glutamyltransferase abnormal 19.37 16.44 8 25215 449 42595663
Cutaneous T-cell lymphoma 19.35 16.44 13 25210 1985 42594127
Expanded disability status scale score decreased 19.30 16.44 3 25220 0 42596112
Dysplastic naevus 19.27 16.44 9 25214 679 42595433
Spinal cord injury cauda equina 19.14 16.44 6 25217 150 42595962
Incorrect dose administered 19.13 16.44 4 25219 52970 42543142
Anti-thyroid antibody positive 18.87 16.44 5 25218 67 42596045
Somatosensory evoked potentials abnormal 18.70 16.44 6 25217 162 42595950
Chronic obstructive pulmonary disease 18.65 16.44 7 25216 63107 42533005
Pollakiuria 18.44 16.44 41 25182 22464 42573648
Chronic kidney disease 18.27 16.44 3 25220 47238 42548874
Vitreous floaters 18.07 16.44 17 25206 4213 42591899
CD8 lymphocytes decreased 17.88 16.44 5 25218 83 42596029
Photophobia 17.83 16.44 23 25200 8096 42588016
Decreased interest 17.78 16.44 14 25209 2731 42593381
B-cell lymphoma 17.73 16.44 18 25205 4895 42591217
Haemoptysis 17.71 16.44 3 25220 46164 42549948
Choroid melanoma 17.69 16.44 4 25219 26 42596086
Influenza like illness 17.66 16.44 50 25173 31790 42564322
Squamous cell carcinoma of skin 17.64 16.44 29 25194 12697 42583415
Globulins decreased 17.62 16.44 7 25216 355 42595757
Halo vision 17.44 16.44 6 25217 202 42595910
CSF glucose decreased 17.43 16.44 4 25219 28 42596084
Dyspnoea 17.33 16.44 173 25050 442448 42153664
Ascites 17.23 16.44 6 25217 56672 42539440
Laryngeal papilloma 17.22 16.44 3 25220 3 42596109
Product use in unapproved indication 17.21 16.44 54 25169 184402 42411710
Sinus arrhythmia 17.20 16.44 9 25214 868 42595244
Solar lentigo 16.85 16.44 8 25215 626 42595486
Hemianopia 16.68 16.44 9 25214 923 42595189
Disturbance in attention 16.66 16.44 47 25176 29819 42566293
Viral vasculitis 16.60 16.44 5 25218 109 42596003

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 5457.51 13.85 1886 85382 48354 110453677
Lymphocyte count decreased 4663.78 13.85 1737 85531 55506 110446525
Lymphopenia 2450.54 13.85 989 86279 39181 110462850
Central nervous system lesion 2247.29 13.85 725 86543 14828 110487203
Expanded disability status scale score increased 1612.07 13.85 317 86951 601 110501430
White blood cell count decreased 1378.35 13.85 1263 86005 228127 110273904
Macular oedema 962.23 13.85 314 86954 6652 110495379
Melanocytic naevus 879.75 13.85 279 86989 5375 110496656
Heart rate decreased 775.52 13.85 590 86678 82166 110419865
Alanine aminotransferase increased 769.21 13.85 832 86436 182941 110319090
Vision blurred 716.93 13.85 681 86587 128341 110373690
Gamma-glutamyltransferase increased 636.65 13.85 465 86803 60844 110441187
Off label use 621.38 13.85 207 87061 1499978 109002053
Optic neuritis 572.56 13.85 243 87025 10904 110491127
Visual impairment 568.11 13.85 612 86656 133816 110368215
Fatigue 529.56 13.85 2122 85146 1213836 109288195
Hypoaesthesia 522.34 13.85 909 86359 313314 110188717
Gait disturbance 498.18 13.85 832 86436 277376 110224655
Headache 471.62 13.85 1646 85622 880731 109621300
JC polyomavirus test positive 420.36 13.85 129 87139 2218 110499813
Progressive multifocal leukoencephalopathy 418.06 13.85 255 87013 24701 110477330
Multiple sclerosis 413.71 13.85 256 87012 25442 110476589
Seborrhoeic keratosis 413.10 13.85 137 87131 3055 110498976
Balance disorder 405.91 13.85 480 86788 116080 110385951
Rebound effect 377.07 13.85 199 87069 14607 110487424
Acute kidney injury 366.63 13.85 38 87230 635392 109866639
Muscular weakness 359.34 13.85 677 86591 247791 110254240
Tumefactive multiple sclerosis 350.65 13.85 67 87201 100 110501931
Secondary progressive multiple sclerosis 331.69 13.85 98 87170 1471 110500560
Ataxia 316.13 13.85 230 87038 29878 110472153
Immune reconstitution inflammatory syndrome 292.97 13.85 174 87094 16052 110485979
Toxicity to various agents 292.48 13.85 23 87245 480532 110021499
Sensory disturbance 278.93 13.85 173 87095 17256 110484775
Aspartate aminotransferase increased 278.81 13.85 473 86795 159463 110342568
Paraesthesia 278.77 13.85 650 86618 275871 110226160
Drug ineffective 275.78 13.85 488 86780 1520052 108981979
Micturition urgency 274.83 13.85 178 87090 19142 110482889
Atrioventricular block second degree 272.90 13.85 132 87136 8049 110493982
Hemiparesis 271.11 13.85 246 87022 43657 110458374
Haemangioma of skin 269.00 13.85 63 87205 350 110501681
Herpes zoster 263.82 13.85 374 86894 108005 110394026
Atrioventricular block first degree 263.26 13.85 155 87113 14070 110487961
Eye pain 262.02 13.85 256 87012 49843 110452188
Prescribed underdose 253.03 13.85 284 86984 64890 110437141
Muscle spasticity 251.23 13.85 216 87052 35699 110466332
Death 251.08 13.85 119 87149 698750 109803281
Dizziness 249.27 13.85 1150 86118 697043 109804988
Lentigo 247.19 13.85 67 87201 721 110501310
Limb discomfort 240.73 13.85 223 87045 40631 110461400
Cognitive disorder 238.57 13.85 319 86949 87192 110414839
Infusion related reaction 238.31 13.85 16 87252 381146 110120885
Breast cancer 238.05 13.85 216 87052 38326 110463705
Concomitant disease aggravated 235.80 13.85 152 87116 16212 110485819
Visual acuity reduced 224.03 13.85 193 87075 31980 110470051
Bradycardia 217.51 13.85 418 86850 155099 110346932
Blood alkaline phosphatase increased 207.94 13.85 268 87000 70667 110431364
Febrile neutropenia 204.94 13.85 11 87257 316756 110185275
Meningitis cryptococcal 202.82 13.85 91 87177 4671 110497360
High density lipoprotein increased 197.91 13.85 65 87203 1404 110500627
Rheumatoid arthritis 191.98 13.85 11 87257 299602 110202429
Drug hypersensitivity 191.62 13.85 60 87208 454030 110048001
Synovitis 189.04 13.85 6 87262 274086 110227945
Joint swelling 187.78 13.85 58 87210 442787 110059244
Solar lentigo 187.62 13.85 63 87205 1461 110500570
CD4 lymphocytes decreased 183.75 13.85 74 87194 2900 110499131
Basal cell carcinoma 178.66 13.85 199 87069 45071 110456960
Low density lipoprotein increased 178.64 13.85 109 87159 10557 110491474
Paraparesis 177.88 13.85 82 87186 4484 110497547
Systemic lupus erythematosus 170.43 13.85 7 87261 254331 110247700
Drug interaction 169.25 13.85 92 87176 500091 110001940
Contraindicated product administered 169.20 13.85 6 87262 248261 110253770
Diplopia 166.77 13.85 185 87083 41709 110460322
Therapeutic product effect decreased 166.18 13.85 6 87262 244310 110257721
Lymphocyte percentage decreased 166.09 13.85 82 87186 5228 110496803
Urinary tract infection 164.06 13.85 598 86670 325684 110176347
Malignant melanoma 161.51 13.85 122 87146 16769 110485262
Vitamin D deficiency 159.93 13.85 126 87142 18426 110483605
Pneumonia 159.53 13.85 280 86988 876434 109625597
Arthropathy 158.56 13.85 20 87248 287502 110214529
Fibrous histiocytoma 158.29 13.85 48 87220 791 110501240
Hand deformity 157.44 13.85 3 87265 218503 110283528
Vertigo 156.71 13.85 261 87007 86609 110415422
Condition aggravated 156.35 13.85 211 87057 734625 109767406
Lymphocyte count increased 156.08 13.85 87 87181 7116 110494915
Memory impairment 152.37 13.85 419 86849 196525 110305506
Product use issue 151.02 13.85 31 87237 311664 110190367
Blood alkaline phosphatase decreased 147.99 13.85 60 87208 2393 110499638
Anaemia 147.42 13.85 129 87139 546957 109955074
Sinus bradycardia 147.34 13.85 147 87121 29336 110472695
Back pain 147.00 13.85 631 86637 370365 110131666
Normal newborn 145.68 13.85 128 87140 21768 110480263
Depression 142.47 13.85 561 86707 316774 110185257
Paresis 140.30 13.85 71 87197 4773 110497258
Intentional product use issue 139.75 13.85 16 87252 247890 110254141
Glossodynia 139.63 13.85 9 87259 221995 110280036
Urinary incontinence 136.82 13.85 180 87088 48407 110453624
Trigeminal neuralgia 135.51 13.85 67 87201 4285 110497746
Psoriatic arthropathy 133.22 13.85 5 87263 196756 110305275
Stomatitis 132.74 13.85 26 87242 270216 110231815
Molluscum contagiosum 127.17 13.85 38 87230 594 110501437
Hypotension 123.32 13.85 139 87129 523710 109978321
Monocyte count increased 120.47 13.85 93 87175 13200 110488831
Drug intolerance 119.28 13.85 88 87180 406424 110095607
Cryptococcal cutaneous infection 119.25 13.85 31 87237 280 110501751
Leukopenia 118.49 13.85 320 86948 148471 110353560
Completed suicide 117.61 13.85 24 87244 242357 110259674
Aphasia 116.91 13.85 185 87083 58812 110443219
Treatment failure 116.21 13.85 37 87231 277197 110224834
Abortion spontaneous 115.63 13.85 139 87129 34143 110467888
Helicobacter infection 115.49 13.85 7 87261 181870 110320161
Swelling 113.75 13.85 68 87200 350973 110151058
Demyelination 112.75 13.85 78 87190 9351 110492680
Rash 112.24 13.85 307 86961 820657 109681374
Wound 112.13 13.85 24 87244 234413 110267618
Malignant neoplasm progression 110.00 13.85 7 87261 174560 110327471
Hyponatraemia 108.88 13.85 20 87248 217633 110284398
Oropharyngeal pain 108.78 13.85 292 86976 134984 110367047
Dysarthria 107.73 13.85 218 87050 83903 110418128
Renal failure 106.74 13.85 24 87244 226550 110275481
Cystoid macular oedema 105.08 13.85 49 87219 2751 110499280
Product use in unapproved indication 103.86 13.85 120 87148 447257 110054774
Drug abuse 103.71 13.85 10 87258 177401 110324630
Movement disorder 102.70 13.85 135 87133 36269 110465762
Skin lesion 102.44 13.85 162 87106 51469 110450562
Thrombocytopenia 101.72 13.85 76 87192 348809 110153222
General physical health deterioration 100.98 13.85 112 87156 425183 110076848
Feeling abnormal 100.87 13.85 343 86925 180368 110321663
Palpitations 100.38 13.85 315 86953 158897 110343134
Blood bilirubin decreased 100.12 13.85 39 87229 1398 110500633
Pericarditis 99.69 13.85 25 87243 219089 110282942
Blood pressure decreased 99.23 13.85 255 87013 114836 110387195
Cervical dysplasia 96.82 13.85 46 87222 2694 110499337
Sensory loss 96.35 13.85 101 87167 21356 110480675
Cryptococcosis 95.09 13.85 54 87214 4577 110497454
Visual field defect 94.64 13.85 72 87196 10000 110492031
Neutrophil count increased 93.90 13.85 126 87142 34526 110467505
Hypersensitivity 93.07 13.85 109 87159 403889 110098142
Expanded disability status scale 92.18 13.85 15 87253 0 110502031
Renal impairment 90.71 13.85 19 87249 188426 110313605
Cryptococcal meningoencephalitis 89.66 13.85 26 87242 364 110501667
Cardiac failure congestive 89.62 13.85 8 87260 150992 110351039
Invasive ductal breast carcinoma 89.06 13.85 59 87209 6587 110495444
Drug monitoring procedure not performed 88.80 13.85 35 87233 1295 110500736
Therapeutic product effect incomplete 88.37 13.85 33 87235 223772 110278259
Muscle injury 87.66 13.85 6 87262 140801 110361230
Delivery 87.25 13.85 32 87236 969 110501062
Haemangioma 86.63 13.85 43 87225 2773 110499258
Cervix carcinoma 85.37 13.85 41 87227 2460 110499571
Dysaesthesia 85.08 13.85 58 87210 6789 110495242
Folliculitis 84.72 13.85 15 87253 167638 110334393
Stress 84.28 13.85 227 87041 105121 110396910
Injection site pain 83.49 13.85 19 87249 177903 110324128
Clumsiness 82.84 13.85 46 87222 3734 110498297
Extensor plantar response 82.11 13.85 37 87231 1918 110500113
Peripheral swelling 81.80 13.85 120 87148 403914 110098117
Gastrointestinal haemorrhage 81.09 13.85 16 87252 165502 110336529
Type 2 diabetes mellitus 81.04 13.85 20 87248 177212 110324819
Magnetic resonance imaging abnormal 81.00 13.85 46 87222 3899 110498132
Wheezing 80.49 13.85 51 87217 255179 110246852
Temperature intolerance 79.95 13.85 75 87193 13875 110488156
Cafe au lait spots 79.89 13.85 13 87255 0 110502031
C-reactive protein abnormal 79.38 13.85 6 87262 129689 110372342
Vomiting 78.53 13.85 411 86857 910264 109591767
Neurogenic bladder 77.69 13.85 49 87219 5030 110497001
Septic shock 77.66 13.85 15 87253 157513 110344518
Diarrhoea 77.08 13.85 555 86713 1138950 109363081
Cardiac failure 76.92 13.85 26 87242 187600 110314431
Pancytopenia 76.15 13.85 35 87233 209578 110292453
Sepsis 75.72 13.85 88 87180 327258 110174773
Fibromyalgia 74.89 13.85 21 87247 170888 110331143
Oedema 74.83 13.85 36 87232 209940 110292091
Decreased immune responsiveness 73.80 13.85 61 87207 9545 110492486
Interstitial lung disease 73.68 13.85 11 87257 139323 110362708
Multiple organ dysfunction syndrome 73.62 13.85 15 87253 151695 110350336
Dysplastic naevus 73.51 13.85 27 87241 821 110501210
White matter lesion 72.91 13.85 38 87230 2716 110499315
Maternal exposure before pregnancy 72.86 13.85 54 87214 7211 110494820
Muscle tightness 72.64 13.85 73 87195 14689 110487342
CD8 lymphocytes decreased 72.55 13.85 21 87247 292 110501739
Depressed mood 72.46 13.85 153 87115 60656 110441375
Fall 71.47 13.85 759 86509 602723 109899308
Urticaria 71.32 13.85 88 87180 318769 110183262
Bladder dysfunction 71.18 13.85 31 87237 1481 110500550
Joint range of motion decreased 70.85 13.85 7 87261 121825 110380206
Loss of personal independence in daily activities 70.42 13.85 16 87252 150004 110352027
Decreased vibratory sense 70.18 13.85 25 87243 695 110501336
Chest discomfort 69.73 13.85 297 86971 173551 110328480
Pruritus 69.65 13.85 231 87037 581329 109920702
Adverse event 69.64 13.85 4 87264 108805 110393226
Hospitalisation 69.33 13.85 14 87254 142479 110359552
Ill-defined disorder 69.23 13.85 19 87249 156834 110345197
Intentional product misuse 69.12 13.85 11 87257 132893 110369138
Exposure during pregnancy 68.98 13.85 23 87245 167401 110334630
Coordination abnormal 68.76 13.85 92 87176 25136 110476895
Muscle spasms 68.41 13.85 414 86854 277743 110224288
Breast mass 67.40 13.85 54 87214 8087 110493944
Pollakiuria 66.95 13.85 123 87145 44072 110457959
Speech disorder 66.62 13.85 149 87119 61420 110440611
Ophthalmoplegia 66.51 13.85 39 87229 3511 110498520
Acrochordon 66.28 13.85 29 87239 1401 110500630
Pain in extremity 65.99 13.85 630 86638 486488 110015543
Oxygen saturation decreased 65.67 13.85 21 87247 156961 110345070
Blister 65.64 13.85 50 87218 227326 110274705
Impaired healing 65.26 13.85 37 87231 196680 110305351
Liver injury 64.94 13.85 19 87249 150394 110351637
Neutrophil percentage increased 64.35 13.85 43 87225 4870 110497161
Influenza like illness 64.28 13.85 184 87084 88228 110413803
Gait spastic 64.06 13.85 29 87239 1520 110500511
Facet joint syndrome 63.73 13.85 3 87265 96825 110405206
Irritable bowel syndrome 63.51 13.85 25 87243 164190 110337841
Wound infection 63.45 13.85 3 87265 96462 110405569
CD4/CD8 ratio decreased 62.96 13.85 14 87254 59 110501972
Anogenital warts 62.45 13.85 26 87242 1110 110500921
Lower respiratory tract infection 62.20 13.85 60 87208 243046 110258985
Skin papilloma 61.95 13.85 48 87220 6848 110495183
Overdose 61.82 13.85 56 87212 233738 110268293
Relapsing-remitting multiple sclerosis 61.71 13.85 31 87237 2051 110499980
Actinic keratosis 61.24 13.85 48 87220 6965 110495066
Pleocytosis 61.09 13.85 29 87239 1695 110500336
Osseous cryptococcosis 61.03 13.85 11 87257 9 110502022
Infection 60.97 13.85 121 87147 362079 110139952
Hyperkalaemia 60.78 13.85 16 87252 135780 110366251
Dizziness postural 60.71 13.85 66 87202 14543 110487488
Motor dysfunction 60.48 13.85 85 87183 24321 110477710
Asthma 60.37 13.85 65 87203 250226 110251805
Hemianaesthesia 60.08 13.85 20 87248 451 110501580
Maternal exposure during pregnancy 59.92 13.85 375 86893 254508 110247523
Hypoglycaemia 59.51 13.85 10 87258 116094 110385937
Vaccination failure 59.07 13.85 32 87236 2474 110499557
Pulmonary fibrosis 58.97 13.85 6 87262 102036 110399995
Respiratory failure 58.84 13.85 50 87218 215282 110286749
Quadriparesis 58.79 13.85 40 87228 4667 110497364
Delirium 58.40 13.85 17 87251 135008 110367023
Burning sensation 58.25 13.85 152 87116 69060 110432971
Migraine 57.45 13.85 278 86990 171374 110330657
Lymphocyte count abnormal 57.24 13.85 31 87237 2395 110499636
Osteoarthritis 56.87 13.85 37 87231 182586 110319445
Lung disorder 56.72 13.85 36 87232 180011 110322020
Superficial spreading melanoma stage unspecified 56.43 13.85 18 87250 353 110501678
Rhabdomyolysis 56.19 13.85 13 87255 120388 110381643
International normalised ratio increased 56.11 13.85 3 87265 86769 110415262
Myelosuppression 55.97 13.85 5 87263 94335 110407696
Monocyte percentage increased 55.94 13.85 30 87238 2273 110499758
Progressive multiple sclerosis 55.43 13.85 25 87243 1299 110500732
Monoparesis 55.23 13.85 38 87230 4515 110497516
Injury 55.08 13.85 36 87232 177229 110324802
Bursitis 55.02 13.85 17 87251 129901 110372130
Lactic acidosis 54.84 13.85 5 87263 92806 110409225
Visceral leishmaniasis 54.57 13.85 27 87241 1729 110500302
Optic atrophy 53.40 13.85 30 87238 2491 110499540
Cardio-respiratory arrest 53.09 13.85 13 87255 115823 110386208
Hypokalaemia 52.81 13.85 40 87228 182408 110319623
Basophil count decreased 52.79 13.85 18 87250 438 110501593
Peroneal nerve palsy 52.67 13.85 45 87223 7369 110494662
Papilloma viral infection 52.35 13.85 28 87240 2110 110499921
Medication error 52.00 13.85 10 87258 105356 110396675
JC polyomavirus test 51.89 13.85 11 87257 35 110501996
Hypoxia 51.27 13.85 19 87249 129496 110372535
Nystagmus 51.10 13.85 54 87214 11523 110490508
Ocular discomfort 51.07 13.85 47 87221 8486 110493545
T-lymphocyte count decreased 50.84 13.85 19 87249 607 110501424
Aspartate aminotransferase decreased 50.54 13.85 24 87244 1404 110500627
Electrocardiogram PR prolongation 50.43 13.85 26 87242 1817 110500214
Band sensation 50.41 13.85 22 87246 1056 110500975
Breast cancer stage III 50.35 13.85 3 87265 79114 110422917
Photophobia 49.93 13.85 80 87188 25691 110476340
Mucosal inflammation 49.90 13.85 8 87260 96133 110405898
Discomfort 49.33 13.85 58 87210 214649 110287382
Concentric sclerosis 49.16 13.85 8 87260 0 110502031
Incontinence 48.96 13.85 63 87205 16572 110485459
Cardiac arrest 48.67 13.85 50 87218 196703 110305328
Wrong technique in product usage process 48.30 13.85 6 87262 87342 110414689
Neutropenia 48.18 13.85 144 87124 374476 110127555
Metabolic acidosis 48.11 13.85 10 87258 99734 110402297
JC virus infection 47.91 13.85 37 87231 5253 110496778
Papule 47.84 13.85 49 87219 10084 110491947
Neuropathy peripheral 47.32 13.85 43 87225 179234 110322797
Intentional overdose 46.77 13.85 23 87245 132478 110369553
Anaphylactic reaction 46.56 13.85 16 87252 114284 110387747
CSF protein increased 46.56 13.85 23 87245 1468 110500563
Rubella antibody positive 46.39 13.85 11 87257 65 110501966
Drug ineffective for unapproved indication 46.24 13.85 12 87256 102826 110399205
Therapy non-responder 46.15 13.85 34 87234 157273 110344758
Gastrointestinal disorder 45.93 13.85 75 87193 241877 110260154
Arthritis 45.67 13.85 39 87229 167547 110334484
Influenza 45.63 13.85 258 87010 168843 110333188
Chronic kidney disease 45.38 13.85 4 87264 76287 110425744
Squamous cell carcinoma 45.30 13.85 64 87204 18399 110483632
Immune thrombocytopenia 45.19 13.85 71 87197 22423 110479608
Upper respiratory tract infection 44.88 13.85 214 87054 131114 110370917
Vitreous floaters 44.63 13.85 45 87223 9089 110492942
Injection site erythema 44.28 13.85 10 87258 94166 110407865
Disturbance in attention 44.07 13.85 128 87140 61867 110440164
Dehydration 43.97 13.85 97 87171 279414 110222617
Inflammation 43.53 13.85 53 87215 193185 110308846
Post herpetic neuralgia 43.50 13.85 29 87239 3272 110498759
Menstruation irregular 42.85 13.85 36 87232 5761 110496270
Lymphomatoid papulosis 42.69 13.85 15 87253 400 110501631
Hypokinesia 42.62 13.85 68 87200 21758 110480273
Obesity 42.62 13.85 18 87250 113333 110388698
Blood bilirubin increased 42.18 13.85 144 87124 75828 110426203
Quadriplegia 42.11 13.85 31 87237 4096 110497935
Dysmetria 41.96 13.85 21 87247 1378 110500653
Monocyte count decreased 41.73 13.85 30 87238 3821 110498210
Alanine aminotransferase decreased 41.44 13.85 23 87245 1865 110500166
Blood creatinine increased 41.37 13.85 50 87218 182839 110319192
Pulmonary embolism 41.16 13.85 66 87202 214408 110287623
Sinus arrhythmia 41.08 13.85 24 87244 2146 110499885
Adverse drug reaction 40.93 13.85 16 87252 105543 110396488
Immunodeficiency 40.90 13.85 93 87175 38745 110463286
Pleural effusion 40.82 13.85 48 87220 177661 110324370
Extrasystoles 40.68 13.85 41 87227 8277 110493754
Photopsia 40.68 13.85 36 87232 6178 110495853
Colitis 40.52 13.85 15 87253 102308 110399723
Live birth 40.37 13.85 4 87264 69480 110432551
Tremor 39.95 13.85 285 86983 201947 110300084
Electrocardiogram PR shortened 39.75 13.85 14 87254 376 110501655
Knee arthroplasty 39.75 13.85 3 87265 64945 110437086
Paralysis 39.65 13.85 55 87213 15545 110486486
Cerebral atrophy 39.43 13.85 42 87226 9043 110492988
Peripheral venous disease 39.41 13.85 9 87259 84108 110417923
Gamma-glutamyltransferase decreased 39.37 13.85 14 87254 387 110501644
Sebaceous hyperplasia 39.33 13.85 10 87258 82 110501949
Blood brain barrier defect 39.11 13.85 12 87256 206 110501825
Rash maculo-papular 38.92 13.85 6 87262 74216 110427815
Retinal cyst 38.47 13.85 11 87257 146 110501885
Angioedema 38.07 13.85 15 87253 98485 110403546
Decreased appetite 38.02 13.85 220 87048 475626 110026405
Haematochezia 37.91 13.85 22 87246 115502 110386529
Pulmonary oedema 37.82 13.85 16 87252 100643 110401388
Rectal haemorrhage 37.68 13.85 24 87244 119809 110382222
Eosinophil count decreased 37.68 13.85 34 87234 5984 110496047
Electrocardiogram abnormal 37.51 13.85 59 87209 18650 110483381
Hypocalcaemia 37.37 13.85 4 87264 65362 110436669
Tinea pedis 37.26 13.85 25 87243 2850 110499181
Non-cardiac chest pain 37.12 13.85 43 87225 10155 110491876
Intraductal proliferative breast lesion 37.03 13.85 25 87243 2880 110499151
Chronic obstructive pulmonary disease 36.96 13.85 20 87248 109138 110392893
CSF measles antibody positive 36.64 13.85 9 87259 63 110501968
Seizure 36.58 13.85 299 86969 220886 110281145
Pneumonitis 36.24 13.85 8 87260 76523 110425508
Prescribed overdose 36.12 13.85 12 87256 87569 110414462
Human papilloma virus test positive 35.86 13.85 15 87253 648 110501383
Neuralgia 35.33 13.85 101 87167 48377 110453654
Acne 35.01 13.85 80 87188 33440 110468591
Anaplastic large cell lymphoma T- and null-cell types 34.96 13.85 11 87257 206 110501825
Relapsing multiple sclerosis 34.86 13.85 11 87257 208 110501823
Product quality issue 34.79 13.85 9 87259 77290 110424741
Injection site swelling 34.77 13.85 4 87264 61786 110440245
Myelitis 34.75 13.85 25 87243 3188 110498843
Presbyopia 34.30 13.85 15 87253 724 110501307
Dyspnoea 34.11 13.85 642 86626 1106230 109395801
Deep vein thrombosis 34.08 13.85 36 87232 139851 110362180
Therapeutic response decreased 33.68 13.85 17 87251 96482 110405549
Anxiety 33.56 13.85 418 86850 344660 110157371
Ophthalmic herpes zoster 33.52 13.85 25 87243 3370 110498661
Decreased interest 33.26 13.85 29 87239 4879 110497152
Protein total decreased 33.24 13.85 42 87226 10848 110491183
Haematocrit increased 33.00 13.85 29 87239 4930 110497101
Hyperreflexia 32.87 13.85 39 87229 9446 110492585
Urinary retention 32.67 13.85 125 87143 69558 110432473
Thrombosis 32.50 13.85 23 87245 108639 110393392
Milia 32.39 13.85 9 87259 107 110501924
Retinal aneurysm 32.36 13.85 11 87257 265 110501766
Varicella zoster virus infection 32.27 13.85 32 87236 6336 110495695
Neuromyelitis optica spectrum disorder 32.01 13.85 18 87250 1497 110500534
Bone marrow failure 31.92 13.85 4 87264 57844 110444187
Treatment noncompliance 31.91 13.85 9 87259 72981 110429050
Tubulointerstitial nephritis 31.87 13.85 3 87265 54281 110447750
Hemiplegia 31.52 13.85 61 87207 22721 110479310
Platelet count decreased 31.50 13.85 86 87182 230357 110271674
Ascites 31.43 13.85 17 87251 92791 110409240
Squamous cell carcinoma of skin 31.42 13.85 52 87216 17151 110484880
Erythema 31.35 13.85 121 87147 291326 110210705
Brain stem syndrome 31.29 13.85 17 87251 1322 110500709
Leiomyosarcoma 31.18 13.85 12 87256 416 110501615
Oral herpes 31.14 13.85 80 87188 36000 110466031
Blood pressure increased 30.98 13.85 326 86942 258047 110243984
Melaena 30.96 13.85 8 87260 68749 110433282
Anti-thyroid antibody positive 30.94 13.85 13 87255 568 110501463
Bladder disorder 30.94 13.85 41 87227 11096 110490935
Fine motor skill dysfunction 30.82 13.85 31 87237 6243 110495788
Injection site reaction 30.62 13.85 16 87252 89054 110412977
Malignant melanoma in situ 30.40 13.85 24 87244 3518 110498513
Macular pigmentation 30.29 13.85 6 87262 12 110502019
Uterine leiomyoma 30.27 13.85 34 87234 7766 110494265
Hepatic cirrhosis 30.20 13.85 8 87260 67618 110434413
Arthralgia 29.97 13.85 434 86834 779198 109722833
Respiratory arrest 29.92 13.85 5 87263 58294 110443737
Abdominal discomfort 29.91 13.85 185 87083 393673 110108358
Hepatic cytolysis 29.91 13.85 4 87264 55049 110446982
Anaphylactic shock 29.86 13.85 3 87265 51543 110450488
Benign neoplasm of skin 29.81 13.85 9 87259 146 110501885
Refraction disorder 29.69 13.85 8 87260 84 110501947
Hyperglycaemia 29.68 13.85 15 87253 85075 110416956
Injection site bruising 29.66 13.85 3 87265 51260 110450771
Injection site pruritus 29.65 13.85 3 87265 51255 110450776
Fluid retention 29.50 13.85 19 87249 94288 110407743
Cytomegalovirus infection 29.48 13.85 4 87264 54440 110447591
Hypertonic bladder 29.41 13.85 28 87240 5274 110496757
Hypomagnesaemia 29.22 13.85 6 87262 60364 110441667
Disease progression 29.11 13.85 97 87171 243937 110258094
Haemoptysis 29.04 13.85 10 87258 71344 110430687
Intervertebral disc protrusion 28.81 13.85 66 87202 27632 110474399
Progressive relapsing multiple sclerosis 28.75 13.85 7 87261 47 110501984
Herpes zoster cutaneous disseminated 28.63 13.85 12 87256 521 110501510
Ligament sprain 28.59 13.85 48 87220 16020 110486011
Janus kinase 2 mutation 28.57 13.85 6 87262 18 110502013
Macular cyst 28.50 13.85 7 87261 49 110501982
Asthenopia 28.37 13.85 22 87246 3142 110498889
Hypervolaemia 28.34 13.85 3 87265 49457 110452574
Personality change 28.28 13.85 39 87229 10963 110491068
Metamorphopsia 28.14 13.85 17 87251 1616 110500415
Genital herpes 27.97 13.85 20 87248 2527 110499504
Colitis ulcerative 27.95 13.85 13 87255 77350 110424681
Blindness 27.72 13.85 77 87191 36282 110465749
Urge incontinence 27.72 13.85 16 87252 1399 110500632
Romberg test positive 27.70 13.85 10 87258 289 110501742
Nail disorder 27.54 13.85 6 87262 57929 110444102
Tinea versicolour 27.46 13.85 12 87256 578 110501453
Keratosis pilaris 27.39 13.85 8 87260 115 110501916
Dysuria 27.38 13.85 107 87161 60124 110441907
Monoplegia 27.38 13.85 26 87242 4883 110497148
Eye movement disorder 27.31 13.85 36 87232 9692 110492339
C-reactive protein increased 27.11 13.85 85 87183 217834 110284197
Hypoglossal nerve paralysis 27.04 13.85 6 87262 25 110502006
Eye disorder 26.94 13.85 66 87202 28840 110473191
Atrial fibrillation 26.89 13.85 92 87176 229550 110272481
Taste disorder 26.89 13.85 9 87259 65378 110436653
Blindness transient 26.67 13.85 28 87240 5928 110496103
Neurocryptococcosis 26.66 13.85 7 87261 66 110501965
Shock 26.62 13.85 5 87263 53583 110448448
Upper gastrointestinal haemorrhage 26.38 13.85 4 87264 50092 110451939
Chest wall mass 26.35 13.85 9 87259 220 110501811
Urobilinogen urine increased 26.33 13.85 12 87256 639 110501392
Sedation 26.30 13.85 11 87257 69672 110432359
Muscle strain 26.26 13.85 38 87230 11164 110490867
Rosacea 25.96 13.85 26 87242 5210 110496821
Ovarian cancer 25.89 13.85 24 87244 4372 110497659
Anal incontinence 25.85 13.85 55 87213 21909 110480122
No adverse event 25.78 13.85 13 87255 73826 110428205
B-cell lymphoma 25.76 13.85 30 87238 7124 110494907
Hepatic failure 25.70 13.85 11 87257 68728 110433303
Pulmonary hypertension 25.69 13.85 6 87262 55214 110446817
Blindness unilateral 25.62 13.85 35 87233 9751 110492280
CD30 expression 25.60 13.85 7 87261 78 110501953
Monkeypox 25.55 13.85 10 87258 363 110501668
Extra dose administered 25.29 13.85 39 87229 12120 110489911
Dysstasia 25.29 13.85 70 87198 32916 110469115
Autoimmune disorder 25.26 13.85 10 87258 65473 110436558
Lower limb fracture 25.22 13.85 14 87254 75334 110426697
Breast discomfort 25.19 13.85 11 87257 529 110501502
Macular fibrosis 25.11 13.85 12 87256 712 110501319
Cystitis 25.07 13.85 111 87157 65925 110436106
Melanocytic hyperplasia 24.92 13.85 5 87263 11 110502020
Maculopathy 24.89 13.85 20 87248 3007 110499024
Glioblastoma 24.68 13.85 17 87251 2023 110500008
Seborrhoeic dermatitis 24.66 13.85 19 87249 2688 110499343
Retinal disorder 24.63 13.85 18 87250 2352 110499679
Drug eruption 24.63 13.85 6 87262 53653 110448378
Heart rate irregular 24.58 13.85 71 87197 34203 110467828
Anti-JC virus antibody index 24.58 13.85 4 87264 0 110502031
Postmature baby 24.58 13.85 4 87264 0 110502031
Expanded disability status scale score decreased 24.58 13.85 4 87264 0 110502031
Eye naevus 24.56 13.85 6 87262 41 110501990
Partial seizures 24.45 13.85 37 87231 11312 110490719
Vaginal dysplasia 24.43 13.85 6 87262 42 110501989
Adjustment disorder with depressed mood 24.30 13.85 3 87265 43880 110458151
Rash pruritic 24.16 13.85 25 87243 98044 110403987
Amenorrhoea 24.14 13.85 33 87235 9198 110492833
Diabetic retinal oedema 23.86 13.85 10 87258 434 110501597
Coma 23.82 13.85 35 87233 117834 110384197
Vibration test abnormal 23.81 13.85 5 87263 15 110502016
Hemianopia 23.69 13.85 19 87249 2849 110499182
Plasma cell myeloma 23.65 13.85 10 87258 62926 110439105
Asthenia 23.60 13.85 711 86557 688288 109813743
Obstructive airways disorder 23.59 13.85 4 87264 46145 110455886
Dysdiadochokinesis 23.57 13.85 10 87258 448 110501583
Haemorrhage 23.25 13.85 30 87238 106662 110395369
Enchondromatosis 23.05 13.85 7 87261 116 110501915
Diabetic ketoacidosis 22.98 13.85 3 87265 42055 110459976
Cutaneous T-cell lymphoma 22.94 13.85 20 87248 3364 110498667
Agranulocytosis 22.91 13.85 10 87258 61750 110440281
Electrocardiogram T wave abnormal 22.88 13.85 22 87246 4195 110497836
Head discomfort 22.85 13.85 48 87220 18952 110483079
Haematemesis 22.84 13.85 9 87259 59099 110442932
Surgery 22.43 13.85 3 87265 41280 110460751
Dysphagia 22.42 13.85 202 87066 153398 110348633
Histoplasmosis disseminated 22.41 13.85 21 87247 3878 110498153
Fear-related avoidance of activities 22.35 13.85 7 87261 129 110501902
Eosinophilia 22.10 13.85 9 87259 57927 110444104
Lupus-like syndrome 22.08 13.85 3 87265 40789 110461242
Enzyme level abnormal 22.04 13.85 8 87260 235 110501796
Cerebellar syndrome 21.98 13.85 26 87242 6276 110495755
Neoplasm skin 21.85 13.85 19 87249 3185 110498846
Cardiogenic shock 21.72 13.85 9 87259 57329 110444702
Osteoporosis 21.71 13.85 22 87246 87130 110414901
Coronary artery disease 21.67 13.85 15 87253 71675 110430356
Heavy menstrual bleeding 21.64 13.85 43 87225 16322 110485709
Multiple lentigines syndrome 21.63 13.85 8 87260 248 110501783
Testicular seminoma (pure) stage I 21.63 13.85 5 87263 26 110502005
Diabetes mellitus 21.60 13.85 28 87240 99353 110402678
Coeliac disease 21.52 13.85 4 87264 43183 110458848
Respiratory distress 21.37 13.85 14 87254 68860 110433171
Abnormal sensation in eye 21.36 13.85 16 87252 2170 110499861
Diffuse large B-cell lymphoma 21.30 13.85 42 87226 15856 110486175
Spinal cord disorder 21.29 13.85 16 87252 2182 110499849
Organic brain syndrome 21.19 13.85 10 87258 577 110501454
Rash erythematous 21.15 13.85 20 87248 81812 110420219
Gastrooesophageal reflux disease 21.14 13.85 72 87196 179904 110322127
Acute respiratory failure 21.13 13.85 17 87251 75243 110426788
Pregnancy 21.05 13.85 7 87261 51060 110450971
Mean cell haemoglobin increased 20.97 13.85 24 87244 5593 110496438
Dysgraphia 20.86 13.85 22 87246 4683 110497348
Incorrect dose administered 20.73 13.85 31 87237 103610 110398421
Neck pain 20.64 13.85 167 87101 122963 110379068
Restless legs syndrome 20.63 13.85 54 87214 24572 110477459
Hallucination 20.62 13.85 30 87238 101402 110400629
Herpes zoster meningoencephalitis 20.61 13.85 12 87256 1066 110500965
White blood cell count increased 20.60 13.85 139 87129 96703 110405328
High density lipoprotein decreased 20.57 13.85 24 87244 5709 110496322
Laryngeal papilloma 20.54 13.85 4 87264 7 110502024
Migraine with aura 20.44 13.85 19 87249 3473 110498558
Frequent bowel movements 20.21 13.85 16 87252 71374 110430657
Dyspnoea exertional 19.97 13.85 32 87236 104028 110398003
Facial pain 19.92 13.85 40 87228 15299 110486732
Intention tremor 19.92 13.85 11 87257 883 110501148
Oedema peripheral 19.78 13.85 165 87103 328495 110173536
Vitamin D decreased 19.78 13.85 35 87233 12180 110489851
Dry mouth 19.62 13.85 86 87182 199862 110302169
Lymphogranuloma venereum 19.58 13.85 4 87264 10 110502021
Ulcer 19.44 13.85 5 87263 43111 110458920
Therapy partial responder 19.42 13.85 3 87265 37058 110464973
Upper motor neurone lesion 19.34 13.85 8 87260 336 110501695
JC virus CSF test positive 19.34 13.85 7 87261 204 110501827
Facial paresis 19.33 13.85 24 87244 6089 110495942
Psoriasis 19.31 13.85 52 87216 139941 110362090
Urinary hesitation 19.28 13.85 21 87247 4637 110497394
Abdominal distension 19.27 13.85 72 87196 175031 110327000
Skin cancer 19.19 13.85 43 87225 17741 110484290
Intestinal obstruction 19.14 13.85 9 87259 53218 110448813
Grip strength decreased 19.12 13.85 21 87247 80153 110421878
Liver function test abnormal 19.12 13.85 106 87162 68844 110433187
Musculoskeletal chest pain 19.02 13.85 58 87210 28789 110473242
Panic attack 18.90 13.85 58 87210 28882 110473149
Skin exfoliation 18.74 13.85 25 87243 87626 110414405
Myopia 18.66 13.85 15 87253 2256 110499775
Gastrointestinal carcinoma 18.62 13.85 18 87250 3455 110498576
Vertigo positional 18.47 13.85 19 87249 3929 110498102
Hemihyperaesthesia 18.44 13.85 3 87265 0 110502031
Unevaluable event 18.43 13.85 12 87256 59215 110442816
HER2 positive breast cancer 18.31 13.85 8 87260 385 110501646
Ventricular extrasystoles 18.31 13.85 49 87219 22592 110479439
Thunderclap headache 18.30 13.85 9 87259 569 110501462
Retinal vein occlusion 18.24 13.85 19 87249 3988 110498043
Amnesia 18.23 13.85 144 87124 105264 110396767
Abortion 18.19 13.85 13 87255 1641 110500390
Colour blindness 18.12 13.85 9 87259 581 110501450
Carcinoma in situ 18.08 13.85 6 87262 134 110501897
Mood altered 18.04 13.85 47 87221 21328 110480703
Hemiparaesthesia 18.02 13.85 8 87260 400 110501631
Nervousness 18.01 13.85 67 87201 36784 110465247
Vulval cancer 17.99 13.85 9 87259 590 110501441
Borderline glaucoma 17.78 13.85 4 87264 18 110502013
Adenocarcinoma of colon 17.59 13.85 23 87245 6145 110495886
Night sweats 17.56 13.85 51 87217 133932 110368099
Urinary sediment abnormal 17.56 13.85 6 87262 147 110501884
Chromaturia 17.49 13.85 57 87211 29303 110472728
Spinal cord injury cauda equina 17.44 13.85 6 87262 150 110501881
Facial spasm 17.35 13.85 10 87258 872 110501159
Hypophagia 17.30 13.85 10 87258 52616 110449415
Haematocrit decreased 17.25 13.85 100 87168 66017 110436014
Cerebral artery stenosis 17.09 13.85 10 87258 897 110501134
Tinea infection 17.07 13.85 12 87256 1476 110500555
Weight increased 17.01 13.85 231 87037 419413 110082618
White blood cells urine positive 16.88 13.85 25 87243 7499 110494532
Choroid melanoma 16.86 13.85 5 87263 76 110501955
Depressed level of consciousness 16.80 13.85 40 87228 112238 110389793
Hemianopia homonymous 16.73 13.85 12 87256 1523 110500508
Respiratory disorder 16.69 13.85 19 87249 71363 110430668
Herpes zoster oticus 16.67 13.85 9 87259 691 110501340
Visual acuity tests abnormal 16.64 13.85 6 87262 173 110501858
Hepatitis E 16.56 13.85 19 87249 4440 110497591
Magnetic resonance imaging head abnormal 16.52 13.85 17 87251 3518 110498513
Swollen tongue 16.50 13.85 14 87254 60348 110441683
Muscle fatigue 16.47 13.85 18 87250 3989 110498042
Disseminated intravascular coagulation 16.43 13.85 6 87262 41280 110460751
Precancerous lesion of digestive tract 16.36 13.85 3 87265 3 110502028
Smear cervix abnormal 16.35 13.85 15 87253 2697 110499334
Lung adenocarcinoma 16.33 13.85 28 87240 9503 110492528
Anxiety disorder 16.28 13.85 20 87248 5020 110497011
Mental fatigue 16.28 13.85 10 87258 980 110501051
Heart rate abnormal 16.17 13.85 24 87244 7214 110494817
Vertigo CNS origin 16.16 13.85 4 87264 29 110502002
Cranial nerve disorder 16.15 13.85 11 87257 1286 110500745
Herpes zoster infection neurological 16.11 13.85 8 87260 516 110501515
Epistaxis 16.11 13.85 51 87217 130321 110371710
Granulocyte count increased 16.09 13.85 13 87255 1970 110500061
CD4 lymphocytes abnormal 16.08 13.85 5 87263 90 110501941
Hypoaesthesia oral 16.04 13.85 39 87229 16963 110485068
Skin ulcer 15.93 13.85 16 87252 63629 110438402
Macular hole 15.90 13.85 10 87258 1021 110501010
Bronchial carcinoma 15.87 13.85 11 87257 1322 110500709
Spinal cord injury 15.86 13.85 12 87256 1653 110500378
Prosopagnosia 15.82 13.85 5 87263 95 110501936
Macule 15.82 13.85 17 87251 3696 110498335
Cervix disorder 15.75 13.85 7 87261 351 110501680
Saccadic eye movement 15.70 13.85 6 87262 204 110501827
Lymphadenopathy 15.65 13.85 95 87173 63740 110438291
Somatosensory evoked potentials abnormal 15.62 13.85 6 87262 207 110501824
Optic nerve disorder 15.62 13.85 12 87256 1691 110500340
Invasive breast carcinoma 15.60 13.85 9 87259 786 110501245
Hypercholesterolaemia 15.56 13.85 30 87238 90807 110411224
Supraventricular extrasystoles 15.55 13.85 25 87243 8048 110493983
Crying 15.49 13.85 50 87218 25578 110476453
Sciatica 15.41 13.85 31 87237 92368 110409663
Selective IgG subclass deficiency 15.30 13.85 4 87264 37 110501994
Trigeminal nerve disorder 15.22 13.85 6 87262 222 110501809
Anti-actin antibody positive 15.15 13.85 3 87265 6 110502025
Hypercalcaemia 15.14 13.85 9 87259 46648 110455383
Blood folate increased 15.12 13.85 8 87260 590 110501441
Red blood cell sedimentation rate increased 15.10 13.85 24 87244 78278 110423753
Pyramidal tract syndrome 15.07 13.85 9 87259 838 110501193
Viral vasculitis 15.05 13.85 6 87262 229 110501802
CSF immunoglobulin increased 14.93 13.85 4 87264 41 110501990
Strabismus 14.87 13.85 16 87252 3483 110498548
Persistent depressive disorder 14.86 13.85 11 87257 1466 110500565
Abdominal pain 14.68 13.85 301 86967 512688 109989343
Hypophosphataemia 14.67 13.85 4 87264 33178 110468853
Coagulopathy 14.59 13.85 7 87261 40904 110461127
Blood creatinine decreased 14.56 13.85 26 87242 9111 110492920
Myoclonus 14.55 13.85 4 87264 32994 110469037
Urine uric acid decreased 14.54 13.85 5 87263 125 110501906
Acute disseminated encephalomyelitis 14.53 13.85 7 87261 423 110501608
Thyroid cancer 14.45 13.85 21 87247 6193 110495838
Meningioma 14.44 13.85 20 87248 5645 110496386
Drug dependence 14.42 13.85 11 87257 50009 110452022
Facial paralysis 14.42 13.85 47 87221 24167 110477864
Solar dermatitis 14.42 13.85 6 87262 256 110501775
Halo vision 14.32 13.85 8 87260 657 110501374
Congenital central nervous system anomaly 14.31 13.85 5 87263 131 110501900
Retention cyst 14.28 13.85 3 87265 9 110502022
Stress urinary incontinence 14.28 13.85 12 87256 1921 110500110
Viral infection 14.27 13.85 81 87187 53058 110448973
Cataract subcapsular 14.07 13.85 10 87258 1251 110500780
Endometrial adenocarcinoma 14.06 13.85 10 87258 1253 110500778
Orthostatic hypotension 14.05 13.85 19 87249 66230 110435801
Naevoid melanoma 14.05 13.85 3 87265 10 110502021
Episcleritis 14.04 13.85 10 87258 1256 110500775
Acanthoma 13.93 13.85 4 87264 54 110501977
Cervix carcinoma stage 0 13.89 13.85 6 87262 281 110501750

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AE01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Sphingosine-1-phosphate (S1P) receptor modulators
MeSH PA D000081243 Sphingosine 1 Phosphate Receptor Modulators
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
FDA MoA N0000181815 Sphingosine 1-Phosphate Receptor Modulators
FDA EPC N0000181816 Sphingosine 1-phosphate Receptor Modulator
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:63114 sphingosine-1-phosphate receptor agonist
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73416 CB<small><sub>1</sub></small> receptor antagonist

Related Drugs by ATC class:

L04AE Sphingosine-1-phosphate (S1P) receptor modulators 4 drugs
etrasimodozanimodponesimodsiponimod

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Relapsing remitting multiple sclerosis indication 426373005 DOID:2378
Disorder of lung contraindication 19829001 DOID:850
Complete atrioventricular block contraindication 27885002
Sick sinus syndrome contraindication 36083008 DOID:13884
Macular retinal edema contraindication 37231002 DOID:4449
Bradycardia contraindication 48867003
Hepatic failure contraindication 59927004
Acute infectious disease contraindication 63171007
Diabetes mellitus contraindication 73211009 DOID:9351
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Uveitis contraindication 128473001 DOID:13141
Liver function tests abnormal contraindication 166603001
Chronic infectious disease contraindication 177010002
Second degree atrioventricular block contraindication 195042002
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.57 acidic
pKa2 13.18 acidic
pKa3 8.51 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 0.5MG BASE GILENYA NOVARTIS N022527 Sept. 21, 2010 RX CAPSULE ORAL 10543179 Dec. 25, 2027 TREATMENT OF RELAPSING REMITTING MULTIPLE SCLEROSIS BY DETERMINING VARICELLA ZOSTER VIRUS (VZV) STATUS AND VACCINATING PRIOR TO COMMENCING TREATMENT
EQ 0.25MG BASE GILENYA NOVARTIS N022527 May 11, 2018 RX CAPSULE ORAL 9592208 March 30, 2032 TREATMENT OF MULTIPLE SCLEROSIS IN THE PEDIATRIC PATIENT POPULATION WITH 0.25 MG FINGOLIMOD

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sphingosine 1-phosphate receptor 4 GPCR AGONIST EC50 9.52 CHEMBL CHEMBL
Sphingosine 1-phosphate receptor 3 GPCR AGONIST EC50 8.52 CHEMBL CHEMBL
Sphingosine 1-phosphate receptor 1 GPCR AGONIST EC50 9.52 CHEMBL CHEMBL
Sphingosine 1-phosphate receptor 5 GPCR AGONIST EC50 9.52 CHEMBL CHEMBL
Sphingosine-1-phosphate lyase 1 Enzyme IC50 4.77 CHEMBL
Troponin C, slow skeletal and cardiac muscles Cytosolic other Kd 5.30 CHEMBL
Sphingosine-1-phosphate lyase 1, S1PL, SP-lyase 1, SPL 1, mSPL, EC 4.1.2.27 Enzyme IC50 4.28 CHEMBL
Transient receptor potential cation channel subfamily M member 7 Ion channel BLOCKER IC50 6.14 IUPHAR

External reference:

IDSource
4030216 VUID
N0000181834 NUI
D04187 KEGG_DRUG
162359-56-0 SECONDARY_CAS_RN
4030216 VANDF
C1699926 UMLSCUI
CHEBI:63115 CHEBI
CHEMBL544665 ChEMBL_ID
CHEMBL314854 ChEMBL_ID
D000068876 MESH_DESCRIPTOR_UI
DB08868 DRUGBANK_ID
2407 IUPHAR_LIGAND_ID
8341 INN_ID
3QN8BYN5QF UNII
107970 PUBCHEM_CID
1012891 RXNORM
177212 MMSL
253713 MMSL
27529 MMSL
d07692 MMSL
013519 NDDF
013520 NDDF
449000008 SNOMEDCT_US
703109008 SNOMEDCT_US
715640009 SNOMEDCT_US
3QN8BYN5QF INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Gilenya HUMAN PRESCRIPTION DRUG LABEL 1 0078-0607 CAPSULE 0.50 mg ORAL NDA 34 sections
Gilenya HUMAN PRESCRIPTION DRUG LABEL 1 0078-0965 CAPSULE 0.25 mg ORAL NDA 34 sections
Fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 0378-4525 CAPSULE 0.50 mg ORAL ANDA 32 sections
Fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 0480-7820 CAPSULE 0.50 mg ORAL ANDA 29 sections
FINGOLIMOD HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16729-342 CAPSULE 0.50 mg ORAL ANDA 30 sections
FINGOLIMOD HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16729-342 CAPSULE 0.50 mg ORAL ANDA 30 sections
Fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 31722-889 CAPSULE 0.50 mg ORAL ANDA 28 sections
Fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 42291-048 CAPSULE 0.50 mg ORAL ANDA 29 sections
FINGOLIMOD HUMAN PRESCRIPTION DRUG LABEL 1 43547-003 CAPSULE 0.50 mg ORAL ANDA 27 sections
Fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 43598-285 CAPSULE 0.50 mg ORAL ANDA 29 sections
Fingolimod Human Prescription Drug Label 1 46708-228 CAPSULE 0.50 mg ORAL ANDA 29 sections
Fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 60505-4332 CAPSULE 0.50 mg ORAL ANDA 30 sections
Fingolimod Human Prescription Drug Label 1 62332-228 CAPSULE 0.50 mg ORAL ANDA 29 sections
Fingolimod Human Prescription Drug Label 1 62756-064 CAPSULE 0.50 mg ORAL ANDA 31 sections
fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 64980-449 CAPSULE 0.50 mg ORAL ANDA 32 sections
FINGOLIMOD Human Prescription Drug Label 1 65862-952 CAPSULE 0.50 mg ORAL ANDA 29 sections
FINGOLIMOD Human Prescription Drug Label 1 65862-952 CAPSULE 0.50 mg ORAL ANDA 29 sections
Fingolimod Human Prescription Drug Label 1 67877-476 CAPSULE 0.50 mg ORAL ANDA 29 sections
Fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 68382-912 CAPSULE 0.50 mg ORAL ANDA 28 sections
fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 68462-166 CAPSULE 0.50 mg ORAL ANDA 29 sections
FINGOLIMOD HUMAN PRESCRIPTION DRUG LABEL 1 70377-019 CAPSULE 0.50 mg ORAL ANDA 30 sections
Fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 70771-1603 CAPSULE 0.50 mg ORAL ANDA 2 sections
Fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 72865-257 CAPSULE 0.50 mg ORAL ANDA 27 sections
fingolimod HUMAN PRESCRIPTION DRUG LABEL 1 73086-300 CAPSULE 0.50 mg ORAL ANDA 29 sections
FINGOLIMOD HUMAN PRESCRIPTION DRUG LABEL 1 82009-143 CAPSULE 0.50 mg ORAL ANDA 30 sections
Fingolimod Human Prescription Drug Label 1 82249-385 CAPSULE 0.50 mg ORAL ANDA 29 sections