bucladesine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
415 362-74-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bucladesine
  • Dibutyryl cAMP
  • dbcAMP
  • Cyclic AMP dibutyrate
  • bucladesine sodium
  • bucladesine sodium salt
A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed)
  • Molecular weight: 469.39
  • Formula: C18H24N5O8P
  • CLOGP: 0.74
  • LIPINSKI: 1
  • HAC: 13
  • HDO: 2
  • TPSA: 163.99
  • ALOGS: -2.46
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AURKA,AURKB,AXL,BRAF,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,ITK,MAP2K6,MAP3K21,MAPK7,NTRK2,PDK1,PDK2,PIK3CD,PRKDC,SIK2,STK33,TEK 26
kinase-selectivity-class AXL,CDK9,GRK2,MAP2K6 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CE04 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Phosphodiesterase inhibitors
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:38147 cardiotonic drug
CHEBI has role CHEBI:48705 agonist

Related Drugs by ATC class:

C01CE Phosphodiesterase inhibitors 3 drugs
amrinoneenoximonemilrinone

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.21 acidic
pKa2 12.91 acidic
pKa3 2.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01238 KEGG_DRUG
C0012054 UMLSCUI
CHEBI:50095 CHEBI
CHEMBL485980 ChEMBL_ID
D003994 MESH_DESCRIPTOR_UI
DB13242 DRUGBANK_ID
5485 IUPHAR_LIGAND_ID
5288 INN_ID
16980-89-5 SECONDARY_CAS_RN
63X7MBT2LQ UNII
9687 PUBCHEM_CID

Pharmaceutical products:

None