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nadide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4140 | 53-84-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK7,NTRK2,PDK1,PDK2,PRKDC,TEK | 18 | |||
| kinase-selectivity-class | AXL,CDK9,ERBB2,GRK2,MAP2K6,MAPK7,PRKDC,TEK | 8 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:78675 | fundamental metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 0.04 | acidic |
| pKa2 | 2.08 | acidic |
| pKa3 | 11.94 | acidic |
| pKa4 | 12.72 | acidic |
| pKa5 | 12.84 | acidic |
| pKa6 | 13.47 | acidic |
| pKa7 | 13.84 | acidic |
| pKa8 | 3.95 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 0U46U6E8UK | UNII |
| N0000170823 | NUI |
| D00002 | KEGG_DRUG |
| C0027270 | UMLSCUI |
| CHEBI:15846 | CHEBI |
| NAD | PDB_CHEM_ID |
| CHEMBL1234613 | ChEMBL_ID |
| 5892 | PUBCHEM_CID |
| DB14128 | DRUGBANK_ID |
| 2371 | INN_ID |
| 1044975 | RXNORM |
| NOCODE | MMSL |
| 008958 | NDDF |
| D009243 | MESH_DESCRIPTOR_UI |
| 2451 | IUPHAR_LIGAND_ID |
| 0U46U6E8UK | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Bonogenhair care shampoo | HUMAN OTC DRUG LABEL | 4 | 50653-1001 | SHAMPOO | 0.30 g | TOPICAL | unapproved drug other | 2 sections |
| Bonogen Plushair care shampoo | HUMAN OTC DRUG LABEL | 4 | 50653-2001 | SHAMPOO | 0.30 g | TOPICAL | unapproved drug other | 2 sections |
| Born Hair | HUMAN OTC DRUG LABEL | 4 | 50653-4001 | SHAMPOO | 0.30 g | TOPICAL | unapproved drug other | 7 sections |
| Virexa | HUMAN PRESCRIPTION DRUG LABEL | 8 | 85477-606 | TABLET | 5 mg | ORAL | unapproved drug other | 5 sections |
| Converthera NAD plus Patch | HUMAN OTC DRUG LABEL | 2 | 85945-0001 | PATCH | 250 mg | TRANSDERMAL | unapproved drug other | 8 sections |