bucillamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	414	65002-17-7

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

bucillamine
rimatil
thiobutarit
tiobutarit

Molecular weight: 223.31
Formula: C7H13NO3S2
CLOGP: 0.36
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 66.40
ALOGS: -2.54
ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,IGF1R,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70	52
kinase-selectivity-class	ACVR2B,AXL,BRAF,CDK9,EPHB4,GRK2,MAP2K6,MAP3K14,MAPK7,PRKDC,STK33,TEK,TGFBR1	13
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Lymphoproliferative disorder	173.89	45.88	30	699	4232	90623486
Diffuse large B-cell lymphoma	71.26	45.88	16	713	8629	90619089
Interstitial lung disease	68.67	45.88	25	704	76380	90551338
Epstein-Barr virus associated lymphoproliferative disorder	64.04	45.88	12	717	2655	90625063

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Lymphoproliferative disorder	75.71	70.40	13	176	3294	42617852

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Lymphoproliferative disorder	233.68	42.01	43	1038	7175	110581043
Interstitial lung disease	93.86	42.01	39	1042	139295	110448923
Diffuse large B-cell lymphoma	82.39	42.01	21	1060	15877	110572341
Epstein-Barr virus associated lymphoproliferative disorder	77.47	42.01	16	1065	4786	110583432
Epstein-Barr virus infection	42.67	42.01	13	1068	18725	110569493

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M01CC02	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS SPECIFIC ANTIRHEUMATIC AGENTS Penicillamine and similar agents
MeSH PA	D000700	Analgesics
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D000975	Antioxidants
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018689	Sensory System Agents
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D020011	Protective Agents

Related Drugs by ATC class:

M01CC Penicillamine and similar agents 1 drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.2	acidic
pKa2	8.46	acidic
pKa3	9.51	acidic
pKa4	13.13	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D01809	KEGG_DRUG
C0073917	UMLSCUI
CHEBI:31312	CHEBI
CHEMBL80830	ChEMBL_ID
DB12160	DRUGBANK_ID
656604	PUBCHEM_CID
C026535	MESH_SUPPLEMENTAL_RECORD_UI
5683	INN_ID
R80LRA5WTF	UNII

Pharmaceutical products:

None