gentian violet Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4138 548-62-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methylrosaniline chloride
  • gentian violet
A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.
  • Molecular weight: 372.54
  • Formula: C25H30N3
  • CLOGP: 0.63
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 9.49
  • ALOGS: -5.32
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:77178 histological dye
CHEBI has role CHEBI:48218 antiseptic drug
CHEBI has role CHEBI:35443 anthelminthic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Candidal vulvovaginitis indication 72605008 DOID:2272
Candidiasis of skin off-label use 49883006
Vaginal irritation contraindication 161816004
Aphthous ulcer of mouth contraindication 426965005 DOID:9663

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.58 Basic
pKa2 6.08 Basic
pKa3 5.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mu-type opioid receptor GPCR Ki 6.06 DRUG MATRIX
D(1A) dopamine receptor GPCR Ki 5.81 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 5.98 DRUG MATRIX
Adenosine receptor A2a GPCR Ki 5.72 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 6.70 DRUG MATRIX
Cytochrome P450 3A4 Enzyme IC50 5.44 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.12 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 6.24 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.55 DRUG MATRIX
Histamine H2 receptor GPCR Ki 5.94 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.58 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.29 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 6.04 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 6.85 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 6.42 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.56 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.49 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.08 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 5.63 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 6.01 DRUG MATRIX
Kappa-type opioid receptor GPCR Ki 6.21 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 5.23 DRUG MATRIX
Epidermal growth factor receptor Kinase IC50 6.33 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.67 DRUG MATRIX
Substance-K receptor GPCR Ki 6.25 DRUG MATRIX
Androgen receptor Transcription factor Ki 5.43 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 5.70 DRUG MATRIX

External reference:

IDSource
D005840 MESH_DESCRIPTOR_UI
4018858 VUID
N0000147160 NUI
C0017440 UMLSCUI
387239001 SNOMEDCT_US
42638008 SNOMEDCT_US
4822 MMSL
4778 RXNORM
4780 MMSL
4018858 VANDF
002617 NDDF
002912 NDDF
CHEMBL64894 ChEMBL_ID
J4Z741D6O5 UNII
113 INN_ID
CHEBI:41688 CHEBI
11057 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Humco Gentian Violet 1% HUMAN OTC DRUG LABEL 1 0395-1003 LIQUID 10 mg TOPICAL OTC monograph not final 12 sections
Humco Gentian Violet 2% HUMAN OTC DRUG LABEL 1 0395-1005 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Gentian Violet 1% HUMAN OTC DRUG LABEL 1 0395-9114 LIQUID 10 mg TOPICAL OTC monograph not final 11 sections
DE LA CRUZ GENTIAN VIOLET HUMAN OTC DRUG LABEL 1 24286-1531 TINCTURE 1 g TOPICAL OTC monograph not final 10 sections
GNP Gentian Violet 1% HUMAN OTC DRUG LABEL 1 24385-003 LIQUID 10 mg TOPICAL OTC monograph not final 11 sections
Gentian Violet 2% HUMAN OTC DRUG LABEL 1 54633-014 SOLUTION 2 g TOPICAL OTC monograph not final 12 sections
Perineze Triple Dye HUMAN OTC DRUG LABEL 3 55739-1022 SOLUTION 2.29 mg TOPICAL OTC monograph not final 9 sections
Gentian Violet Topical Solution HUMAN OTC DRUG LABEL 1 65055-401 LIQUID 1 g TOPICAL OTC monograph not final 11 sections
Kerr 100 Triple Dye Dispos-A HUMAN OTC DRUG LABEL 3 66689-710 SWAB 2.20 mg TOPICAL OTC MONOGRAPH NOT FINAL 9 sections