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prasterone sulfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| androgens/anabolic steroids | 4049 | 651-48-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK | 18 | |||
| kinase-selectivity-class | AXL,GRK2,MAP2K6,ZAP70 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:75771 | mouse metabolite |
| CHEBI has role | CHEBI:77194 | EC 2.7.1.33 (pantothenate kinase) inhibitor |
| CHEBI has role | CHEBI:77746 | human metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 0.53 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4021360 | VANDF |
| 4036745 | VANDF |
| C0057277 | UMLSCUI |
| CHEBI:16814 | CHEBI |
| ZQK | PDB_CHEM_ID |
| DB05804 | DRUGBANK_ID |
| 12594 | PUBCHEM_CID |
| 57B09Q7FJR | UNII |
| 3143 | RXNORM |
| 131731 | MMSL |
| 20676 | MMSL |
| 32118 | MMSL |
| 73034 | MMSL |
| d04425 | MMSL |
| 004609 | NDDF |
| 103044003 | SNOMEDCT_US |
| 413963008 | SNOMEDCT_US |
| 78316004 | SNOMEDCT_US |
| D019314 | MESH_DESCRIPTOR_UI |
| C0011185 | UMLSCUI |
| DB01708 | DRUGBANK_ID |
| 5881 | PUBCHEM_CID |
| 4528 | IUPHAR_LIGAND_ID |
| 2869 | INN_ID |
| C000731675 | MESH_SUPPLEMENTAL_RECORD_UI |
| CHEBI:28689 | CHEBI |
| 57B09Q7FJR | INXIGHT DRUGS |
Pharmaceutical products:
None