binifibrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
clofibrate derivatives, peroxisome proliferator activated receptor-alpha(PPAR-alpha) agonists 372 69047-39-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • binifibrate
  • biniwas
two nicotinic & one clofibiric radical esterified by glycerol moiety
  • Molecular weight: 498.92
  • Formula: C25H23ClN2O7
  • CLOGP: 4.12
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 0
  • TPSA: 113.91
  • ALOGS: -4.77
  • ROTB: 13

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 68 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,MAP3K7,MAPK12,MAPK7,MAPK9,MARK4,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK 32
kinase-selectivity-class AXL,BRAF,CDK9,DYRK1B,ERBB2,GRK2,SIK2 7
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D057847 Lipid Regulating Agents
MeSH PA D000924 Anticholesteremic Agents
CHEBI has role CHEBI:25212 metabolite
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35679 antilipemic drug
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:50247 antidote
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:84087 human urinary metabolite
CHEBI has role CHEBI:84264 EC 3.5.1.19 (nicotinamidase) inhibitor
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:24527 herbicide
CHEBI has role CHEBI:70782 PPARα agonist
CHEBI has role CHEBI:83399 marine xenobiotic metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.34 Basic
pKa2 2.74 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07529 KEGG_DRUG
7393 RXNORM
C0053612 UMLSCUI
CHEBI:135800 CHEBI
NIO PDB_CHEM_ID
CHEMBL2106582 ChEMBL_ID
C038877 MESH_SUPPLEMENTAL_RECORD_UI
4956 INN_ID
9NGZ4GPE20 UNII
68884 PUBCHEM_CID
2275 MMSL
43641 MMSL
5169 MMSL
7161 MMSL
d00314 MMSL
273943001 SNOMEDCT_US
63639004 SNOMEDCT_US
C0009003 UMLSCUI
C0027996 UMLSCUI
DB00627 DRUGBANK_ID
2797 PUBCHEM_CID
938 PUBCHEM_CID
2439 INN_ID
4017661 VANDF
4019440 VANDF
D002995 MESH_DESCRIPTOR_UI
001052 NDDF
CHEBI:34648 CHEBI
CHEBI:15940 CHEBI

Pharmaceutical products:

None