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thiram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3601	137-26-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: thiram rhenogran tetramethylthioperoxydicarbonic diamide tetramethylthiuram bisulfide tetramethylthiuram disulfide tetramethylthiuram disulphide thioscabin thiuram thiuramin thiuramyl thylate	A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations. Molecular weight: 240.42 Formula: C6H12N2S4 CLOGP: 1.76 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 6.48 ALOGS: -3.74 ROTB: 3

Molecule

Description

Molfile Inchi Smiles

Synonyms:

thiram
rhenogran
tetramethylthioperoxydicarbonic diamide
tetramethylthiuram bisulfide
tetramethylthiuram disulfide
tetramethylthiuram disulphide
thioscabin
thiuram
thiuramin
thiuramyl
thylate

A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.

Molecular weight: 240.42
Formula: C6H12N2S4
CLOGP: 1.76
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 6.48
ALOGS: -3.74
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	P03AA05	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Sulfur containing products
FDA CS	M0000728	Allergens
MeSH PA	D005659	Fungicides, Industrial
MeSH PA	D009153	Mutagens
MeSH PA	D009676	Noxae
MeSH PA	D010575	Pesticides
CHEBI has role	CHEBI:36047	antibacterial drugs
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:86328	anti-fungal agrichemical
FDA PE	N0000175629	Increased Histamine Release
FDA PE	N0000184306	Cell-mediated Immunity
FDA EPC	N0000185508	Standardized Chemical Allergen

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Fructose-1,6-bisphosphatase 1	Enzyme	P09467	F16P1_HUMAN	IC50	5.64	CHEMBL
Fatty-acid amide hydrolase 1	Enzyme	O00519	FAAH1_HUMAN	IC50	4.35	CHEMBL
Aldehyde dehydrogenase, mitochondrial	Enzyme	P05091	ALDH2_HUMAN	IC50	6.50	CHEMBL
Retinal dehydrogenase 1	Enzyme	P00352	AL1A1_HUMAN	IC50	7.70	CHEMBL
Gamma-butyrobetaine dioxygenase	Enzyme	O75936	BODG_HUMAN	IC50	5.24	CHEMBL
Monoglyceride lipase	Enzyme	Q99685	MGLL_HUMAN	IC50	6.01	CHEMBL
Protein-lysine 6-oxidase	Enzyme	P28300	LYOX_HUMAN	IC50	5.98	CHEMBL
Lysyl oxidase homolog 3	Enzyme	P58215	LOXL3_HUMAN	IC50	6.96	CHEMBL
Lysyl oxidase homolog 4	Enzyme	Q96JB6	LOXL4_HUMAN	IC50	6.75	CHEMBL
Histone-lysine N-methyltransferase EHMT2	Enzyme	Q96KQ7	EHMT2_HUMAN	IC50	6.26	CHEMBL
Histone-lysine N-methyltransferase EHMT1	Enzyme	Q9H9B1	EHMT1_HUMAN	IC50	5.96	CHEMBL
Lysyl oxidase homolog 2	Enzyme	Q9Y4K0	LOXL2_HUMAN	IC50	6.77	CHEMBL
Bifunctional protein GlmU	Enzyme		GLMU_MYCTU	IC50	4.05	CHEMBL

External reference:

ID	Source
N0000166713	NUI
D06114	KEGG_DRUG
C0039962	UMLSCUI
CHEBI:9495	CHEBI
CHEMBL120563	ChEMBL_ID
DB13245	DRUGBANK_ID
D013893	MESH_DESCRIPTOR_UI
5455	PUBCHEM_CID
1051	INN_ID
0D771IS0FH	UNII
10517	RXNORM
007028	NDDF
39012008	SNOMEDCT_US
411489009	SNOMEDCT_US

Pharmaceutical products:

None