thiram Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3601 137-26-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiram
  • rhenogran
  • tetramethylthioperoxydicarbonic diamide
  • tetramethylthiuram bisulfide
  • tetramethylthiuram disulfide
  • tetramethylthiuram disulphide
  • thioscabin
  • thiuram
  • thiuramin
  • thiuramyl
  • thylate
A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.
  • Molecular weight: 240.42
  • Formula: C6H12N2S4
  • CLOGP: 1.76
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 6.48
  • ALOGS: -3.74
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC P03AA05 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS
ECTOPARASITICIDES, INCL. SCABICIDES
Sulfur containing products
FDA CS M0000728 Allergens
MeSH PA D005659 Fungicides, Industrial
MeSH PA D009153 Mutagens
MeSH PA D009676 Noxae
MeSH PA D010575 Pesticides
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:48218 local microbicides
CHEBI has role CHEBI:86328 antifungal agrichemical
FDA PE N0000175629 Increased Histamine Release
FDA PE N0000184306 Cell-mediated Immunity
FDA EPC N0000185508 Standardized Chemical Allergen

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Fatty-acid amide hydrolase 1 Enzyme IC50 4.35 CHEMBL
Gamma-butyrobetaine dioxygenase Enzyme IC50 5.24 CHEMBL
Monoglyceride lipase Enzyme IC50 6.01 CHEMBL
Protein-lysine 6-oxidase Enzyme IC50 5.98 CHEMBL
Lysyl oxidase homolog 3 Enzyme IC50 6.96 CHEMBL
Lysyl oxidase homolog 4 Enzyme IC50 6.75 CHEMBL
Histone-lysine N-methyltransferase EHMT2 Enzyme IC50 6.26 CHEMBL
Histone-lysine N-methyltransferase EHMT1 Enzyme IC50 5.96 CHEMBL
Lysyl oxidase homolog 2 Enzyme IC50 6.77 CHEMBL
Bifunctional protein GlmU Enzyme IC50 4.05 CHEMBL

External reference:

IDSource
N0000166713 NUI
D06114 KEGG_DRUG
C0039962 UMLSCUI
CHEBI:9495 CHEBI
CHEMBL120563 ChEMBL_ID
DB13245 DRUGBANK_ID
D013893 MESH_DESCRIPTOR_UI
5455 PUBCHEM_CID
1051 INN_ID
0D771IS0FH UNII
10517 RXNORM
007028 NDDF
39012008 SNOMEDCT_US
411489009 SNOMEDCT_US

Pharmaceutical products:

None