sulmazole Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3574 73384-60-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulmazol
  • isomazole
  • sulmazole
  • vardax
  • AR-L 115 BS
  • Molecular weight: 287.34
  • Formula: C14H13N3O2S
  • CLOGP: 1.01
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 67.87
  • ALOGS: -2.53
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.62 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.41 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.80 hours Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution) 1.67 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 20.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.48 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:38147 cardiotonic drugs
CHEBI has role CHEBI:50218 phosphodiesterase inhibitors
CHEBI has role CHEBI:63957 adenosine A1 receptor antagonists

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.72 acidic
pKa2 4.6 Basic
pKa3 1.29 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme IC50 4.68 CHEMBL
Phosphodiesterase 3 Enzyme IC50 4.30 CHEMBL

External reference:

IDSource
86315-52-8 SECONDARY_CAS_RN
C0075619 UMLSCUI
CHEBI:34988 CHEBI
CHEMBL286020 ChEMBL_ID
CHEMBL2110680 ChEMBL_ID
C029758 MESH_SUPPLEMENTAL_RECORD_UI
5353 PUBCHEM_CID
4925 INN_ID
5839 INN_ID
HK56EH9K44 UNII

Pharmaceutical products:

None