stallimycin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 3553 636-47-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • stallimycin
  • Distamycin 3
  • Distamycin A
  • stallimycin hydrochloride
  • stallimycin HCl
  • Molecular weight: 481.52
  • Formula: C22H27N9O4
  • CLOGP: -0.39
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 181.06
  • ALOGS: -3.37
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.13 acidic
pKa2 12.94 acidic
pKa3 13.41 acidic
pKa4 10.01 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA topoisomerase 1 Enzyme IC50 5.57 CHEMBL
Estrogen receptor Nuclear hormone receptor IC50 7.70 CHEMBL
GTPase HRas Cytosolic other IC50 6.70 CHEMBL

External reference:

IDSource
D05916 KEGG_DRUG
6576-51-8 SECONDARY_CAS_RN
C0244119 UMLSCUI
DMY PDB_CHEM_ID
CHEMBL11252 ChEMBL_ID
CHEMBL19687 ChEMBL_ID
3115 PUBCHEM_CID
C030000 MESH_SUPPLEMENTAL_RECORD_UI
3346 INN_ID
80O63P88IS UNII

Pharmaceutical products:

None