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betamethasone butyrate propionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prednisone and prednisolone derivatives | 352 | 5534-02-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a topical corticosteroid
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.06 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 3.706 | High | 0.81 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.951 | High | 0.81 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 65.766 | 10^-6 cm/s | High | 0.81 |
| dh-clint | Dog hepatocyte intrinsic clearance | 67.608 | uL/min/10^6 cells | High | 0.81 |
| dppb | Dog plasma protein binding (% unbound) | 1.570 | % | High | 0.81 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 2.940 | % | High | 0.81 |
| herg | hERG pIC50 | 4.871 | pIC50 | High | 0.81 |
| hh-clint | Human hepatocyte intrinsic clearance | 167.494 | uL/min/10^6 cells | High | 0.81 |
| hlm-clint | Human liver microsomal intrinsic clearance | 256.448 | uL/min/mg protein | High | 0.81 |
| hppb | Human plasma protein binding (% unbound) | 2.010 | % | High | 0.81 |
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PIM2,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 | 32 | |||
| kinase-selectivity-class | AXL,GRK2,MAP2K6 | 3 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 3.436 | High | 0.81 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 159.588 | High | 0.81 | |
| mppb | Mouse plasma protein binding (% unbound) | 1.770 | High | 0.81 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 13.366 | High | 0.81 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | Moderate | 0.77 | |
| pppb | Pig plasma protein binding (% unbound) | 4.400 | % | High | 0.81 |
| rh-clint | Rat hepatocyte intrinsic clearance | 172.982 | uL/min/10^6 cells | High | 0.81 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 15.790 | % | High | 0.81 |
| rppb | Rat plasma protein binding (% unbound) | 1.350 | % | High | 0.81 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 8.995 | uM | High | 0.81 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drug |
| CHEBI has role | CHEBI:35480 | analgesic |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35705 | immunosuppressive agent |
| CHEBI has role | CHEBI:35845 | gout suppressant |
| CHEBI has role | CHEBI:39456 | antiglaucoma drug |
| CHEBI has role | CHEBI:49201 | anti-ulcer drug |
| CHEBI has role | CHEBI:50177 | dermatologic drug |
| CHEBI has role | CHEBI:50748 | antipsoriatic |
| CHEBI has role | CHEBI:51177 | antitussive |
| CHEBI has role | CHEBI:65023 | anti-asthmatic agent |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:77715 | nasal decongestant |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D019141 | Respiratory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.48 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D02032 | KEGG_DRUG |
| 1514 | RXNORM |
| CHEBI:135815 | CHEBI |
| CHEMBL1697785 | ChEMBL_ID |
| C000612965 | MESH_SUPPLEMENTAL_RECORD_UI |
| C587113 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB00443 | DRUGBANK_ID |
| 10006 | MMSL |
| 4270 | MMSL |
| d00628 | MMSL |
| C2698381 | UMLSCUI |
| C0005308 | UMLSCUI |
| 71470 | PUBCHEM_CID |
| 9782 | PUBCHEM_CID |
| 50FH5AG9RW | UNII |
| 1045 | INN_ID |
| 4018644 | VANDF |
| D001623 | MESH_DESCRIPTOR_UI |
| 002168 | NDDF |
| 116571008 | SNOMEDCT_US |
| 29896003 | SNOMEDCT_US |
| CHEBI:3077 | CHEBI |
| 50FH5AG9RW | INXIGHT DRUGS |
Pharmaceutical products:
None