revaprazan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
proton pump inhibitors, not dependent on acid activation 3525 199463-33-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • revaprazan hydrochloride
  • revaprazan
  • revaprazan HCl
  • YH 1885
  • revanex
  • YH1885
proton pump inhibitor
  • Molecular weight: 362.45
  • Formula: C22H23FN4
  • CLOGP: 6.57
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 1
  • TPSA: 41.05
  • ALOGS: -4.53
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 15, 2005 Korean Food and Drug Administration (KFDA)

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Duodenal ulcer disease indication 51868009 DOID:1724
Gastro-esophageal reflux disease with esophagitis indication 266433003
Gastric ulcer indication 397825006 DOID:10808




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.34 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D05722 KEGG_DRUG
178307-42-1 SECONDARY_CAS_RN
C2699073 UMLSCUI
CHEBI:135529 CHEBI
CHEMBL1618279 ChEMBL_ID
CHEMBL1257753 ChEMBL_ID
DB16308 DRUGBANK_ID
C108798 MESH_SUPPLEMENTAL_RECORD_UI
204104 PUBCHEM_CID
12007 IUPHAR_LIGAND_ID
8415 INN_ID
5P184180P5 UNII

Pharmaceutical products:

None