Stem definition | Drug id | CAS RN |
---|---|---|
351 | 22298-29-9 |
None
Property | Value | Reference |
---|---|---|
S (Water solubility) | 0.06 mg/mL | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA | PARKE DAVIS |
None
None
None
None
Source | Code | Description |
---|---|---|
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:35705 | immunosuppressive agents |
CHEBI has role | CHEBI:65023 | anti-asthmatic agents |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D005938 | Glucocorticoids |
MeSH PA | D006728 | Hormones |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D019141 | Respiratory System Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Contact dermatitis | indication | 40275004 | DOID:2773 |
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Lichen simplex chronicus | indication | 53891004 | |
Granuloma annulare | indication | 65508009 | DOID:3777 |
Pruritus ani | indication | 90446007 | |
Discoid lupus erythematosus | indication | 200938002 | |
Plaque psoriasis | indication | 200965009 | |
Scalp psoriasis | indication | 238608008 | |
Pruritus of genital organs | indication | 267802000 | |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Primary cutaneous T-cell lymphoma | indication | 400122007 | |
Telangiectasia disorder | contraindication | 247479008 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.29 | acidic |
pKa2 | 11.94 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
ID | Source |
---|---|
4018641 | VUID |
N0000146954 | NUI |
D02286 | KEGG_DRUG |
1514 | RXNORM |
C0005311 | UMLSCUI |
CHEBI:135798 | CHEBI |
CHEBI:3077 | CHEBI |
CHEMBL1200376 | ChEMBL_ID |
C015706 | MESH_SUPPLEMENTAL_RECORD_UI |
877K0XW47A | UNII |
5282492 | PUBCHEM_CID |
DB00443 | DRUGBANK_ID |
10006 | MMSL |
4270 | MMSL |
4272 | MMSL |
d00628 | MMSL |
116571008 | SNOMEDCT_US |
17908000 | SNOMEDCT_US |
29896003 | SNOMEDCT_US |
C0005308 | UMLSCUI |
4018641 | VANDF |
4018644 | VANDF |
1045 | INN_ID |
9782 | PUBCHEM_CID |
D001623 | MESH_DESCRIPTOR_UI |
002168 | NDDF |
002170 | NDDF |
None