betamethasone acibutate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
350 5534-05-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betamethasone acibutate
  • Molecular weight: 504.60
  • Formula: C28H37FO7
  • CLOGP: 3.70
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -5.06
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.06 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.186 Moderate 0.71
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.016 Moderate 0.71
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 72.277 10^-6 cm/s Moderate 0.71
dh-clint Dog hepatocyte intrinsic clearance 59.979 uL/min/10^6 cells Moderate 0.71
dppb Dog plasma protein binding (% unbound) 4.460 % Moderate 0.71
fcs-ppb Fetal calf serum protein binding (% unbound) 7.440 % Moderate 0.71
herg hERG pIC50 4.640 pIC50 Moderate 0.71
hh-clint Human hepatocyte intrinsic clearance 126.765 uL/min/10^6 cells Moderate 0.71
hlm-clint Human liver microsomal intrinsic clearance 252.348 uL/min/mg protein Moderate 0.71
hppb Human plasma protein binding (% unbound) 5.970 % Moderate 0.71
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKDC,STK33,SYK,TEK,ZAP70 29
kinase-selectivity-class GRK2,MAP2K6 2
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 4.710 Moderate 0.71
mh-clint Mouse hepatocyte intrinsic clearance 167.109 Moderate 0.71
mppb Mouse plasma protein binding (% unbound) 4.420 Moderate 0.71
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 13.152 Moderate 0.71
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 10.430 % Moderate 0.71
rh-clint Rat hepatocyte intrinsic clearance 185.353 uL/min/10^6 cells Moderate 0.71
rh-fuinc Rat hepatocyte fraction unbound in incubation 32.470 % Moderate 0.71
rppb Rat plasma protein binding (% unbound) 3.840 % Moderate 0.71
solubility-dd Solubility at pH 7.4 in DMSO 50.119 uM Moderate 0.71

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
CHEBI has role CHEBI:35472 anti-inflammatory drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:77715 nasal decongestant
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.48 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
1514 RXNORM
C2698380 UMLSCUI
CHEBI:50894 CHEBI
CHEMBL1697784 ChEMBL_ID
3158 INN_ID
90I96070LY UNII
111080 PUBCHEM_CID
DB00443 DRUGBANK_ID
10006 MMSL
4270 MMSL
d00628 MMSL
C0005308 UMLSCUI
9782 PUBCHEM_CID
1045 INN_ID
4018644 VANDF
D001623 MESH_DESCRIPTOR_UI
002168 NDDF
116571008 SNOMEDCT_US
29896003 SNOMEDCT_US
CHEBI:3077 CHEBI
90I96070LY INXIGHT DRUGS

Pharmaceutical products:

None