piroctone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3479 50650-76-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • piroctone olamine
  • octopirox
  • piroctone
2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)- combined with 2-aminoethanol; used to treat pityriasis; structure given in first source
  • Molecular weight: 237.34
  • Formula: C14H23NO2
  • CLOGP: 3.22
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 40.54
  • ALOGS: -2.83
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 68
kinase-selectivity-class AXL,BRAF,GRK2,TEK 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:59010 antiseborrheic
CHEBI has role CHEBI:88188 drug allergen

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.67 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05504 KEGG_DRUG
68890-66-4 SECONDARY_CAS_RN
C0771954 UMLSCUI
CHEBI:59009 CHEBI
CHEMBL1473700 ChEMBL_ID
DB15946 DRUGBANK_ID
CHEMBL2107154 ChEMBL_ID
50259 PUBCHEM_CID
C052599 MESH_SUPPLEMENTAL_RECORD_UI
4808 INN_ID
R49EFA73Q7 UNII
2058907 RXNORM
006536 NDDF
006537 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
GZE Black Castor Oil EdgeControl HUMAN OTC DRUG LABEL 1 83566-189 GEL 4.40 g TOPICAL OTC Monograph Drug 11 sections
anti-fungal HUMAN OTC DRUG LABEL 2 84558-012 SHAMPOO 0.08 g TOPICAL OTC Monograph Drug 12 sections
FORTE Magnetic S3 Oil Control Anti-Dandfuff HUMAN OTC DRUG LABEL 1 84655-101 LOTION/SHAMPOO 0.40 g TOPICAL unapproved drug other 9 sections
VENROCK HUMAN OTC DRUG LABEL 2 85772-0002 SPRAY 0.50 g TOPICAL OTC Monograph Drug 14 sections
Scalp Soothing HUMAN OTC DRUG LABEL 1 87765-002 POWDER 0.50 g TOPICAL OTC Monograph Drug 8 sections