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piroctone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3479 | 50650-76-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)- combined with 2-aminoethanol; used to treat pityriasis; structure given in first source
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 | 68 | |||
| kinase-selectivity-class | AXL,BRAF,GRK2,TEK | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:59010 | antiseborrheic |
| CHEBI has role | CHEBI:88188 | drug allergen |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.67 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D05504 | KEGG_DRUG |
| 68890-66-4 | SECONDARY_CAS_RN |
| C0771954 | UMLSCUI |
| CHEBI:59009 | CHEBI |
| CHEMBL1473700 | ChEMBL_ID |
| DB15946 | DRUGBANK_ID |
| CHEMBL2107154 | ChEMBL_ID |
| 50259 | PUBCHEM_CID |
| C052599 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4808 | INN_ID |
| R49EFA73Q7 | UNII |
| 2058907 | RXNORM |
| 006536 | NDDF |
| 006537 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| GZE Black Castor Oil EdgeControl | HUMAN OTC DRUG LABEL | 1 | 83566-189 | GEL | 4.40 g | TOPICAL | OTC Monograph Drug | 11 sections |
| anti-fungal | HUMAN OTC DRUG LABEL | 2 | 84558-012 | SHAMPOO | 0.08 g | TOPICAL | OTC Monograph Drug | 12 sections |
| FORTE Magnetic S3 Oil Control Anti-Dandfuff | HUMAN OTC DRUG LABEL | 1 | 84655-101 | LOTION/SHAMPOO | 0.40 g | TOPICAL | unapproved drug other | 9 sections |
| VENROCK | HUMAN OTC DRUG LABEL | 2 | 85772-0002 | SPRAY | 0.50 g | TOPICAL | OTC Monograph Drug | 14 sections |
| Scalp Soothing | HUMAN OTC DRUG LABEL | 1 | 87765-002 | POWDER | 0.50 g | TOPICAL | OTC Monograph Drug | 8 sections |