octocrylene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3395	6197-30-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: octocrylene octocrilene	ingredient in sunscreens and cosmetics Molecular weight: 361.49 Formula: C24H27NO2 CLOGP: 6.84 LIPINSKI: 1 HAC: 3 HDO: 0 TPSA: 50.09 ALOGS: -5.36 ROTB: 10 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

octocrylene
octocrilene

ingredient in sunscreens and cosmetics

Molecular weight: 361.49
Formula: C24H27NO2
CLOGP: 6.84
LIPINSKI: 1
HAC: 3
HDO: 0
TPSA: 50.09
ALOGS: -5.36
ROTB: 10

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 21, 2006	FDA	LOREAL USA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	709.45	15.39	225	9244	24151	63455402
Chronic sinusitis	217.07	15.39	79	9390	12764	63466789
Paraesthesia oral	189.35	15.39	80	9389	19176	63460377
Therapy interrupted	178.28	15.39	90	9379	32365	63447188
Procedural pain	177.40	15.39	79	9390	21490	63458063
Body tinea	110.43	15.39	30	9439	1855	63477698
Vaginal flatulence	106.40	15.39	33	9436	3260	63476293
Therapy cessation	102.15	15.39	61	9408	30396	63449157
Inhibitory drug interaction	98.18	15.39	30	9439	2819	63476734
Proctitis	93.87	15.39	34	9435	5407	63474146

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	115.70	16.72	213	5173	397836	34553709
Therapy interrupted	107.42	16.72	49	5337	13648	34937897
Anal inflammation	72.31	16.72	20	5366	1280	34950265
Therapy cessation	69.13	16.72	39	5347	16934	34934611
SARS-CoV-2 test negative	62.81	16.72	17	5369	1003	34950542
Proctalgia	49.69	16.72	22	5364	5701	34945844
Accident	49.03	16.72	21	5365	5026	34946519
Surgery	43.17	16.72	27	5359	14130	34937415
Appendicolith	41.17	16.72	22	5364	8579	34942966
Ventricular fibrillation	39.90	16.72	31	5355	22923	34928622

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Therapy interrupted	305.06	14.89	134	13320	31207	79699727
Death	215.63	14.89	360	13094	566154	79164780
Macular degeneration	202.55	14.89	75	13379	11221	79719713
Chronic sinusitis	195.69	14.89	76	13378	12950	79717984
Paraesthesia oral	175.08	14.89	80	13374	20391	79710543
Therapy cessation	174.29	14.89	97	13357	37465	79693469
Procedural pain	159.87	14.89	78	13376	23006	79707928
Body tinea	107.25	14.89	30	13424	1824	79729110
Vaginal flatulence	106.05	14.89	32	13422	2543	79728391
Surgery	103.33	14.89	66	13388	32700	79698234

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
004367	NDDF
22571	PUBCHEM_CID
423007005	SNOMEDCT_US
4719	INN_ID
5A68WGF6WM	UNII
69296007	SNOMEDCT_US
77674	RXNORM
C0257715	UMLSCUI
C088673	MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135526	CHEBI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Almay Healthy Biome Makeup	HUMAN OTC DRUG LABEL	5	0311-0723	EMULSION	5 mg	TOPICAL	OTC monograph final	7 sections
Blue Lizard Active Sunscreen	HUMAN OTC DRUG LABEL	2	0316-2071	LOTION	41.80 mg	TOPICAL	OTC monograph not final	9 sections
Blue Lizard Kids Sunscreen	HUMAN OTC DRUG LABEL	2	0316-2061	LOTION	41.80 mg	TOPICAL	OTC monograph not final	8 sections
Blue Lizard Regular	HUMAN OTC DRUG LABEL	4	0316-2010	LOTION	20.40 mg	TOPICAL	OTC monograph final	8 sections
Blue Lizard Sport Original Sunscreen	HUMAN OTC DRUG LABEL	4	0316-2019	LOTION	20.40 mg	TOPICAL	OTC monograph not final	8 sections
Blue Lizard Sport Sunscreen	HUMAN OTC DRUG LABEL	2	0316-2021	LOTION	41.80 mg	TOPICAL	OTC monograph not final	9 sections
Blue Lizard Sport Sunscreen	HUMAN OTC DRUG LABEL	2	0316-2021	LOTION	41.80 mg	TOPICAL	OTC monograph not final	9 sections
Cetaphil	HUMAN OTC DRUG LABEL	2	0299-3928	LOTION	10 g	TOPICAL	OTC monograph final	10 sections
Cetaphil	HUMAN OTC DRUG LABEL	2	0299-3928	LOTION	10 g	TOPICAL	OTC monograph final	10 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35	HUMAN OTC DRUG LABEL	4	0299-4113	LOTION	70 mg	TOPICAL	OTC monograph final	12 sections

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