octocrylene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3395 6197-30-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • octocrylene
  • octocrilene
ingredient in sunscreens and cosmetics
  • Molecular weight: 361.49
  • Formula: C24H27NO2
  • CLOGP: 6.84
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 50.09
  • ALOGS: -5.36
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP3K1,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,STK33,TEK,TTK 39
kinase-selectivity-class AXL,GRK2,PDK4,STK33,TEK 5
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
July 21, 2006 FDA LOREAL USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 1192.29 28.53 327 7400 37643 90583077
Chronic sinusitis 468.81 28.53 143 7584 23659 90597061
Paraesthesia oral 428.67 28.53 143 7584 31516 90589204
Procedural pain 401.74 28.53 138 7589 33222 90587498
Vaginal flatulence 396.05 28.53 109 7618 12529 90608191
Female genital tract fistula 393.31 28.53 117 7610 17751 90602969
Radiculopathy 376.34 28.53 114 7613 18391 90602329
Proctitis 375.73 28.53 109 7618 15150 90605570
Vaginal discharge 349.56 28.53 109 7618 19355 90601365
Oral candidiasis 285.53 28.53 109 7618 35346 90585374
Haematochezia 239.47 28.53 118 7609 70795 90549925
Colitis ulcerative 235.95 28.53 111 7616 60155 90560565
Frequent bowel movements 235.71 28.53 109 7618 56826 90563894
Colitis 226.13 28.53 113 7614 69829 90550891
Rectal haemorrhage 222.26 28.53 118 7609 82626 90538094
Therapeutic product effect incomplete 207.44 28.53 154 7573 193742 90426978
Dyspepsia 173.93 28.53 140 7587 198020 90422700
Drug ineffective 150.94 28.53 349 7378 1383949 89236771
Constipation 109.69 28.53 127 7600 280268 90340452
Erythema 108.94 28.53 115 7612 229131 90391589
Weight decreased 108.59 28.53 147 7580 379763 90240957
Anaemia 95.47 28.53 133 7594 352669 90268051
Infusion related reaction 88.21 28.53 140 7587 416640 90204080
Pyrexia 81.81 28.53 176 7551 660309 89960411
Abdominal pain 76.99 28.53 128 7599 395593 90225127
Carbuncle 67.01 28.53 17 7710 1419 90619301
Malaise 63.31 28.53 148 7579 585838 90034882
Monoclonal immunoglobulin present 60.41 28.53 17 7710 2107 90618613
Hypothalamo-pituitary disorder 59.43 28.53 17 7710 2235 90618485
Amyloid arthropathy 50.31 28.53 14 7713 1666 90619054
Asthma-chronic obstructive pulmonary disease overlap syndrome 50.18 28.53 18 7709 4881 90615839
Total lung capacity increased 49.75 28.53 18 7709 5003 90615717
Overweight 46.82 28.53 18 7709 5916 90614804
Off label use 46.54 28.53 201 7526 1102051 89518669
Nasal polyps 45.47 28.53 21 7706 10859 90609861
Cholelithiasis 43.59 28.53 36 7691 52470 90568250
Nausea 43.48 28.53 198 7529 1110118 89510602
Fibrosis 43.22 28.53 17 7710 5935 90614785
Wrist deformity 41.25 28.53 14 7713 3224 90617496
Hypomania 39.78 28.53 18 7709 8879 90611841
Nephropathy 39.14 28.53 18 7709 9217 90611503
Jaundice cholestatic 37.70 28.53 18 7709 10025 90610695
Sarcoidosis 36.65 28.53 18 7709 10655 90610065
Bronchiectasis 36.24 28.53 23 7704 22307 90598413
Renal cyst 36.19 28.53 19 7708 12931 90607789
Dyslipidaemia 34.57 28.53 17 7710 10090 90610630
Fatigue 31.89 28.53 31 7696 1153992 89466728
Body height decreased 31.88 28.53 17 7710 11932 90608788
Proctalgia 31.71 28.53 15 7712 8183 90612537
Rhinitis allergic 31.59 28.53 19 7708 16766 90603954
Pulmonary pain 31.58 28.53 13 7714 5101 90615619
Purpura 31.15 28.53 18 7709 14760 90605960
Schizophrenia 30.99 28.53 18 7709 14896 90605824
Joint swelling 29.52 28.53 4 7723 503296 90117424
Pain 28.58 28.53 163 7564 996178 89624542

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anal inflammation 162.36 21.84 34 2007 2195 42617099
SARS-CoV-2 test negative 152.19 21.84 31 2010 1744 42617550
Accident 126.15 21.84 34 2007 6469 42612825
Proctalgia 123.23 21.84 34 2007 7059 42612235
Haemorrhoids 90.06 21.84 33 2008 17064 42602230
Body temperature increased 88.01 21.84 34 2007 20324 42598970
Febrile neutropenia 45.65 21.84 50 1991 185653 42433641
Back pain 38.00 21.84 40 2001 141736 42477558
Chills 35.43 21.84 32 2009 94034 42525260
Pyrexia 33.54 21.84 64 1977 393978 42225316
Neutropenia 30.02 21.84 42 1999 199389 42419905
Vomiting 28.30 21.84 50 1991 289673 42329621
Pain 24.85 21.84 43 1998 244805 42374489
Malaise 22.48 21.84 38 2003 212118 42407176
Diarrhoea 22.44 21.84 60 1981 460789 42158505

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 507.29 22.42 148 9060 21511 110558580
Chronic sinusitis 456.07 22.42 141 9067 24943 110555148
Paraesthesia oral 415.27 22.42 141 9067 33530 110546561
Female genital tract fistula 400.53 22.42 116 9092 16403 110563688
Vaginal flatulence 398.11 22.42 108 9100 12036 110568055
Procedural pain 388.41 22.42 136 9072 35429 110544662
Radiculopathy 369.67 22.42 113 9095 19223 110560868
Proctitis 362.64 22.42 108 9100 16819 110563272
Vaginal discharge 356.63 22.42 108 9100 17800 110562291
Oral candidiasis 259.91 22.42 108 9100 44652 110535439
Frequent bowel movements 214.60 22.42 109 9099 71281 110508810
Colitis ulcerative 209.18 22.42 110 9098 77253 110502838
Therapeutic product effect incomplete 193.00 22.42 155 9053 223650 110356441
Rectal haemorrhage 189.10 22.42 120 9088 119713 110460378
Colitis 188.22 22.42 113 9095 102210 110477881
Haematochezia 188.08 22.42 118 9090 115406 110464685
Dyspepsia 179.10 22.42 139 9069 190826 110389265
Anal inflammation 134.50 22.42 33 9175 2463 110577628
Proctalgia 134.42 22.42 48 9160 13174 110566917
SARS-CoV-2 test negative 123.83 22.42 30 9178 2123 110577968
Pyrexia 105.64 22.42 231 8977 898034 109682057
Weight decreased 102.91 22.42 158 9050 467899 110112192
Constipation 102.45 22.42 137 9071 357649 110222442
Infusion related reaction 101.66 22.42 141 9067 381021 110199070
Erythema 96.57 22.42 120 9088 291327 110288764
Malaise 89.53 22.42 182 9026 671637 109908454
Accident 86.40 22.42 33 9175 10919 110569172
Carbuncle 67.05 22.42 17 9191 1450 110578641
Anaemia 65.51 22.42 142 9066 546944 110033147
Pain 62.01 22.42 197 9011 954758 109625333
Abdominal pain 61.23 22.42 133 9075 512856 110067235
Monoclonal immunoglobulin present 57.80 22.42 17 9191 2523 110577568
Hypothalamo-pituitary disorder 55.89 22.42 17 9191 2829 110577262
Total lung capacity increased 53.62 22.42 19 9189 5093 110574998
Amyloid arthropathy 50.64 22.42 14 9194 1666 110578425
Asthma-chronic obstructive pulmonary disease overlap syndrome 49.62 22.42 19 9189 6325 110573766
Haemorrhoids 47.08 22.42 32 9176 35640 110544451
Overweight 45.73 22.42 18 9190 6446 110573645
Nasal polyps 45.05 22.42 22 9186 13178 110566913
Wrist deformity 41.79 22.42 14 9194 3175 110576916
Body temperature increased 40.97 22.42 35 9173 54678 110525413
Hypomania 40.90 22.42 19 9189 10191 110569900
Nausea 39.78 22.42 205 9003 1235485 109344606
Fibrosis 39.50 22.42 17 9191 7625 110572466
Cholelithiasis 38.43 22.42 36 9172 63386 110516705
Sarcoidosis 37.13 22.42 19 9189 12560 110567531
Rhinitis allergic 36.04 22.42 21 9187 17901 110562190
Jaundice cholestatic 34.46 22.42 19 9189 14589 110565502
Body height decreased 34.24 22.42 17 9191 10546 110569545
Bronchiectasis 30.75 22.42 25 9183 36468 110543623
Renal cyst 30.61 22.42 19 9189 18153 110561938
Nephropathy 30.35 22.42 17 9191 13450 110566641
Bone density decreased 30.17 22.42 18 9190 16024 110564067
Off label use 29.36 22.42 219 8989 1499966 109080125
Pulmonary pain 29.28 22.42 13 9195 6280 110573811
Dyslipidaemia 27.67 22.42 17 9191 15948 110564143
Cardiac murmur 27.62 22.42 20 9188 24608 110555483
Dyspnoea 27.59 22.42 31 9177 1106841 109473250
Schizophrenia 27.43 22.42 19 9189 21807 110558284
Joint swelling 26.41 22.42 3 9205 442842 110137249
Fatigue 23.38 22.42 41 9167 1215917 109364174
Therapeutic product effect delayed 23.27 22.42 10 9198 4469 110575622
Toxicity to various agents 22.69 22.42 6 9202 480549 110099542

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05227 KEGG_DRUG
C0257715 UMLSCUI
CHEBI:135526 CHEBI
CHEMBL1201147 ChEMBL_ID
DB09535 DRUGBANK_ID
C088673 MESH_SUPPLEMENTAL_RECORD_UI
22571 PUBCHEM_CID
4719 INN_ID
5A68WGF6WM UNII
77674 RXNORM
004367 NDDF
423007005 SNOMEDCT_US
69296007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.02 g TOPICAL OTC Monograph Drug 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.02 g TOPICAL OTC Monograph Drug 8 sections
SOLBAR THIRTY HUMAN OTC DRUG LABEL 5 0096-0689 GEL 15 mg TOPICAL OTC Monograph Drug 11 sections
SOLBAR SUNSCREEN 50 FIFTY HUMAN OTC DRUG LABEL 4 0096-0693 CREAM 100 mg TOPICAL OTC Monograph Drug 10 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.02 g TOPICAL OTC Monograph Drug 11 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.02 g TOPICAL OTC Monograph Drug 11 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.10 g TOPICAL OTC Monograph Drug 8 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.10 g TOPICAL OTC Monograph Drug 8 sections
Mederma Scar Cream HUMAN OTC DRUG LABEL 3 0113-4083 CREAM 100 mg TOPICAL OTC Monograph Drug 13 sections
Cetaphil HUMAN OTC DRUG LABEL 2 0299-3928 LOTION 10 g TOPICAL OTC Monograph Drug 10 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 70 mg TOPICAL OTC Monograph Drug 13 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 80 mg TOPICAL OTC Monograph Drug 13 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4133 LOTION 7 g TOPICAL OTC Monograph Drug 11 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4134 LOTION 7 g TOPICAL OTC Monograph Drug 10 sections
Cetaphil Healthy Renew Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4136 LOTION 95 mg TOPICAL OTC Monograph Drug 13 sections
Cetaphil Hydrating Face Sunscreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4142 LOTION 70 mg TOPICAL OTC Monograph Drug 13 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 70 mg TOPICAL OTC Monograph Drug 12 sections
Almay Healthy Biome Makeup HUMAN OTC DRUG LABEL 5 0311-0723 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Almay Healthy Biome MakeupFair HUMAN OTC DRUG LABEL 5 0311-0737 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Almay Healthy Biome MakeupLight HUMAN OTC DRUG LABEL 5 0311-0738 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Almay Healthy Biome MakeupMedium HUMAN OTC DRUG LABEL 5 0311-0739 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Almay Healthy Biome MakeupGolden HUMAN OTC DRUG LABEL 5 0311-0740 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Almay Healthy Biome MakeupTan HUMAN OTC DRUG LABEL 5 0311-0741 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Walgreens SPF 70 Sport Continuous HUMAN OTC DRUG LABEL 4 0363-0035 SPRAY 100 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 55 Sheer Face Mist Sunscreen HUMAN OTC DRUG LABEL 4 0363-0053 SPRAY 1000 mg TOPICAL OTC Monograph Drug 13 sections
Walgreens SPF 50 Clear Complexion Face Sunscreen HUMAN OTC DRUG LABEL 4 0363-0066 LOTION 60 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 30 Sport HUMAN OTC DRUG LABEL 4 0363-0093 LOTION 60 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 50 Sport Continuous Sunscreen HUMAN OTC DRUG LABEL 4 0363-0128 SPRAY 40 mg TOPICAL OTC Monograph Drug 12 sections
WALGREENS SPF 100 SHEER BODY SUNSCREEN MIST HUMAN OTC DRUG LABEL 4 0363-0135 AEROSOL, SPRAY 100 mg TOPICAL OTC Monograph Drug 13 sections
Walgreens SPF 50 Hydrating HUMAN OTC DRUG LABEL 4 0363-0136 LOTION 50 mg TOPICAL OTC Monograph Drug 12 sections