nitracrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
acridine derivatives 3386 4533-39-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ledakrin
  • C-283
  • C283
  • nitracrine
Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
  • Molecular weight: 324.38
  • Formula: C18H20N4O2
  • CLOGP: 4.37
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 73.98
  • ALOGS: -4.17
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.07 Basic
pKa2 6.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C0028120 UMLSCUI
CHEBI:135384 CHEBI
CHEMBL26291 ChEMBL_ID
D009564 MESH_DESCRIPTOR_UI
20628 PUBCHEM_CID
3916 INN_ID
712MLZ30SB UNII

Pharmaceutical products:

None