nifenalol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
aromatic ring -CH(-OH)-CH2-NH-R 3380 7413-36-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nifenalol
  • isophenethanol
  • racemic nifenalol
adrenergic beta-blocker with good antiarrhythmic properties; also tends to lower blood pressure & provide protection against angina; minor descriptor (75-86); on-line & INDEX MEDICUS search ETHANOLAMINES (75-86); RN given refers to parent cpd without isomeric designation
  • Molecular weight: 224.26
  • Formula: C11H16N2O3
  • CLOGP: 1.16
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.40
  • ALOGS: -2.54
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.34 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR Kd 5.88 CHEMBL

External reference:

IDSource
C0068737 UMLSCUI
CHEBI:134921 CHEBI
CHEMBL127349 ChEMBL_ID
6317 PUBCHEM_CID
C100250 MESH_SUPPLEMENTAL_RECORD_UI
2734 INN_ID
D1DE63830P UNII

Pharmaceutical products:

None