nifenalol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
aromatic ring -CH(-OH)-CH2-NH-R 3380 7413-36-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nifenalol
  • isophenethanol
  • racemic nifenalol
adrenergic beta-blocker with good antiarrhythmic properties; also tends to lower blood pressure & provide protection against angina; minor descriptor (75-86); on-line & INDEX MEDICUS search ETHANOLAMINES (75-86); RN given refers to parent cpd without isomeric designation
  • Molecular weight: 224.26
  • Formula: C11H16N2O3
  • CLOGP: 1.16
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.40
  • ALOGS: -2.54
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.34 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR Kd 5.88 CHEMBL

External reference:

IDSource
C0068737 UMLSCUI
CHEBI:134921 CHEBI
CHEMBL127349 ChEMBL_ID
C100250 MESH_SUPPLEMENTAL_RECORD_UI
2734 INN_ID
D1DE63830P UNII
6317 PUBCHEM_CID

Pharmaceutical products:

None