linoleic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3323 | 60-33-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:76924 | plant metabolites |
| CHEBI has role | CHEBI:83038 | Daphnia galeata metabolites |
| CHEBI has role | CHEBI:84735 | algal metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.76 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.89 | CHEMBL | |||||
| Aromatase | Enzyme | IC50 | 4.32 | CHEMBL | |||||
| Aldo-keto reductase family 1 member C3 | Enzyme | IC50 | 6.16 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor alpha | Nuclear hormone receptor | Kd | 8.32 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | IC50 | 5.21 | CHEMBL | |||||
| Fatty acid-binding protein, adipocyte | Cytosolic other | IC50 | 6 | CHEMBL | |||||
| Fatty acid-binding protein, heart | Cytosolic other | Kd | 9.70 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor delta | Nuclear hormone receptor | IC50 | 5 | CHEMBL | |||||
| Free fatty acid receptor 1 | GPCR | AGONIST | EC50 | 5.70 | IUPHAR | ||||
| Potassium voltage-gated channel subfamily B member 1 | Ion channel | ACTIVATOR | EC50 | 5.60 | IUPHAR | ||||
| Tissue factor | Membrane receptor | IC50 | 4.39 | CHEMBL | |||||
| Free fatty acid receptor 4 | GPCR | AGONIST | EC50 | 5.89 | IUPHAR | ||||
| Adenosine receptor A1 | GPCR | IC50 | 4.19 | CHEMBL | |||||
| Seed linoleate 13S-lipoxygenase-1 | Enzyme | IC50 | 6 | CHEMBL | |||||
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 4.03 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020238 | VUID |
| N0000148142 | NUI |
| 4020238 | VANDF |
| C0023749 | UMLSCUI |
| CHEBI:17351 | CHEBI |
| EIC | PDB_CHEM_ID |
| CHEMBL267476 | ChEMBL_ID |
| DB14104 | DRUGBANK_ID |
| D019787 | MESH_DESCRIPTOR_UI |
| 5280450 | PUBCHEM_CID |
| 1052 | IUPHAR_LIGAND_ID |
| 9KJL21T0QJ | UNII |
| 6400 | RXNORM |
| 005003 | NDDF |
| 012326 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| PrimaCare | HUMAN PRESCRIPTION DRUG LABEL | 14 | 75854-322 | PILL | 50 mg | oral | unapproved drug other | 11 sections |
| Dr.Different VITAACNAL TX Capsule Serum | HUMAN OTC DRUG LABEL | 2 | 81710-110 | LIQUID | 0.76 g | TOPICAL | unapproved drug other | 8 sections |
| AnubisMed | HUMAN OTC DRUG LABEL | 28 | 83021-551 | CREAM | 0.50 g | TOPICAL | OTC monograph final | 7 sections |
| Anubis Barcelona Protective Line | HUMAN OTC DRUG LABEL | 27 | 83021-686 | CREAM | 0.50 g | TOPICAL | OTC monograph final | 9 sections |