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linoleic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3323	60-33-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: linoleic acid alpha-Linoleic acid linolic acid	A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed) Molecular weight: 280.45 Formula: C18H32O2 CLOGP: 7.30 LIPINSKI: 1 HAC: 2 HDO: 1 TPSA: 37.30 ALOGS: -6.26 ROTB: 14

Molecule

Description

Molfile Inchi Smiles

Synonyms:

linoleic acid
alpha-Linoleic acid
linolic acid

A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)

Molecular weight: 280.45
Formula: C18H32O2
CLOGP: 7.30
LIPINSKI: 1
HAC: 2
HDO: 1
TPSA: 37.30
ALOGS: -6.26
ROTB: 14

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatotoxicity	64.97	46.73	16	167	37025	63451814

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FDA Adverse Event Reporting System (Male)

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatotoxicity	57.62	50.99	16	244	51336	79692792
Regurgitation	53.25	50.99	9	251	2778	79741350

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FDA Adverse Event Reporting System (Pediatric)

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Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:83038	Daphnia galeata metabolites
CHEBI has role	CHEBI:84735	algal metabolites

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Drug Use | Suggest Off label Use Form| |View source of the data|

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🐶 Veterinary Drug Use

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🐶 Veterinary products

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Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.76	acidic

Orange Book patent data (new drug applications)

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Orange Book exclusivity data (new drug applications)

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Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	4.89	CHEMBL
Aromatase	Enzyme	P11511	CP19A_HUMAN		IC50	4.32	CHEMBL
Aldo-keto reductase family 1 member C3	Enzyme	P42330	AK1C3_HUMAN		IC50	6.16	CHEMBL
Peroxisome proliferator-activated receptor alpha	Nuclear hormone receptor	Q07869	PPARA_HUMAN		Kd	8.32	CHEMBL
Peroxisome proliferator-activated receptor gamma	Nuclear hormone receptor	P37231	PPARG_HUMAN		IC50	5.21	CHEMBL
Fatty acid-binding protein, adipocyte	Cytosolic other	P15090	FABP4_HUMAN		IC50	6	CHEMBL
Fatty acid-binding protein, heart	Cytosolic other	P05413	FABPH_HUMAN		Kd	9.70	CHEMBL
Peroxisome proliferator-activated receptor delta	Nuclear hormone receptor	Q03181	PPARD_HUMAN		IC50	5	CHEMBL
Free fatty acid receptor 1	GPCR	O14842	FFAR1_HUMAN	AGONIST	EC50	5.70	IUPHAR
Potassium voltage-gated channel subfamily B member 1	Ion channel	Q14721	KCNB1_HUMAN	ACTIVATOR	EC50	5.60	IUPHAR

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External reference:

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ID	Source
EIC	PDB_CHEM_ID
005003	NDDF
012326	NDDF
1052	IUPHAR_LIGAND_ID
4020238	VUID
4020238	VANDF
5280450	PUBCHEM_CID
6400	RXNORM
9KJL21T0QJ	UNII
C0023749	UMLSCUI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Anubis Barcelona Protective Line	HUMAN OTC DRUG LABEL	27	83021-686	CREAM	0.50 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Protective Line	HUMAN OTC DRUG LABEL	27	83021-686	CREAM	0.50 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Vital Line	HUMAN OTC DRUG LABEL	23	83021-064	CREAM	0.16 g	TOPICAL	OTC monograph final	5 sections
AnubisMed	HUMAN OTC DRUG LABEL	28	83021-551	CREAM	0.50 g	TOPICAL	OTC monograph final	7 sections
Dr.Different VITAACNAL TX Capsule Serum	HUMAN OTC DRUG LABEL	2	81710-110	LIQUID	0.76 g	TOPICAL	unapproved drug other	8 sections
PrimaCare	HUMAN PRESCRIPTION DRUG LABEL	14	75854-322	PILL	50 mg	oral	unapproved drug other	11 sections

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