khellin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3313 82-02-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • khellin
  • amicardien
  • amicardine
  • amikellin
  • khelline
  • medekellin
  • methafrone
A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
  • Molecular weight: 260.25
  • Formula: C14H12O5
  • CLOGP: 2.58
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 57.90
  • ALOGS: -3.21
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35523 bronchodilator agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35554 cardiovascular drugs
CHEBI has role CHEBI:35620 vasodilator
CHEBI has role CHEBI:65023 antiasthmatic agent

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167253 NUI
C0022643 UMLSCUI
CHEBI:6133 CHEBI
CHEMBL44746 ChEMBL_ID
3828 PUBCHEM_CID
D007666 MESH_DESCRIPTOR_UI
192 INN_ID
5G117T0TJZ UNII
6147 RXNORM
006616 NDDF
63869009 SNOMEDCT_US

Pharmaceutical products:

None