homosalate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3279 118-56-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • homosalate
  • homomenthyl salicylate
  • kemester
cpd not photoallergenic
  • Molecular weight: 262.35
  • Formula: C16H22O3
  • CLOGP: 5.92
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -3.85
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Skin burning sensation 64.08 21.74 21 1613 10671 46673757
Macular degeneration 50.73 21.74 16 1618 7189 46677239
Dry skin 39.62 21.74 22 1612 40994 46643434
Skin exfoliation 27.31 21.74 16 1618 32922 46651506
Erythema 27.16 21.74 29 1605 142791 46541637
Pain of skin 26.38 21.74 10 1624 7732 46676696
Jarisch-Herxheimer reaction 25.65 21.74 5 1629 307 46684121
Skin irritation 23.35 21.74 9 1625 7278 46677150
Dermatophytosis 21.87 21.74 4 1630 174 46684254

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood prolactin abnormal 27.10 21.75 6 975 735 29950762

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.91 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021147 VUID
N0000179485 NUI
D04450 KEGG_DRUG
4021147 VANDF
C0304631 UMLSCUI
CHEBI:91642 CHEBI
CHEMBL1377575 ChEMBL_ID
DB11064 DRUGBANK_ID
C060446 MESH_SUPPLEMENTAL_RECORD_UI
3183 INN_ID
V06SV4M95S UNII
8362 PUBCHEM_CID
91326 RXNORM
001969 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0023-5501 LOTION 60 mg TOPICAL OTC MONOGRAPH NOT FINULLL 14 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.12 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.10 1 TOPICAL OTC monograph final 8 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.06 g TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 95 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 125 mg TOPICAL OTC monograph final 12 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 5 mg TOPICAL OTC monograph final 8 sections
Almay Best Blend Forever Makeup HUMAN OTC DRUG LABEL 4 0311-0719 LOTION 3.50 mg TOPICAL OTC monograph final 5 sections
Almay Healthy Biome Makeup HUMAN OTC DRUG LABEL 5 0311-0723 EMULSION 5 mg TOPICAL OTC monograph final 7 sections
Hydrating Antioxidant Moiturizer HUMAN OTC DRUG LABEL 4 0363-0540 CREAM 4.72 g TOPICAL OTC monograph not final 11 sections
WALGREEN SPORT SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0900 LOTION 100 mg TOPICAL OTC monograph not final 12 sections
WALGREENS SPORT SPF 50 SUNSCREEN HUMAN OTC DRUG LABEL 4 0363-0924 AEROSOL, SPRAY 100 mg TOPICAL OTC monograph not final 14 sections
WALGREENS SPORT SPF 50 SUNSCREEN HUMAN OTC DRUG LABEL 4 0363-0925 AEROSOL, SPRAY 100 mg TOPICAL OTC monograph not final 14 sections
WALGREENS BROAD SPECTRUM SPF 110 AGE PROTECTION SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0933 LOTION 150 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0936 STICK 150 mg TOPICAL OTC monograph not final 11 sections
WALGREENS SPORT BROAD SPECTRUM SPF 50 FACES SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0937 LOTION 130 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0940 LOTION 70 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPORT SPF 50 SUNSCREEN HUMAN OTC DRUG LABEL 4 0363-0943 LOTION 100 mg TOPICAL OTC monograph not final 12 sections
Walgreens Sport SPF 50 HUMAN OTC DRUG LABEL 5 0363-0956 SPRAY 100 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF55 Sunscreen HUMAN OTC DRUG LABEL 4 0363-0961 STICK 150 mg TOPICAL OTC monograph not final 12 sections
Hydrating SPF 50 HUMAN OTC DRUG LABEL 4 0363-1120 SPRAY 15 g TOPICAL OTC monograph not final 7 sections
Hydrating SPF 50 HUMAN OTC DRUG LABEL 4 0363-1121 LOTION 15 g TOPICAL OTC monograph not final 7 sections
Hydrating SPF 30 HUMAN OTC DRUG LABEL 4 0363-1123 SPRAY 15 g TOPICAL OTC monograph not final 9 sections
Hydrating SPF 30 HUMAN OTC DRUG LABEL 4 0363-1124 LOTION 10 g TOPICAL OTC monograph not final 7 sections
70 Dry Touch SPF 70 HUMAN OTC DRUG LABEL 5 0363-1125 STICK 15 g TOPICAL OTC monograph not final 8 sections
Walgreens Sunscreen Sport SFP 70 HUMAN OTC DRUG LABEL 5 0363-1671 LOTION 15 g TOPICAL OTC monograph not final 13 sections
Walgreen Sport SPF 50 HUMAN OTC DRUG LABEL 5 0363-2720 LOTION 13 g TOPICAL OTC monograph not final 13 sections
SPF 55 Sport SunstickWell at Walgreens HUMAN OTC DRUG LABEL 5 0363-3215 STICK 15 g TOPICAL OTC monograph not final 10 sections
Walgreens Sport Faces SPF 30 HUMAN OTC DRUG LABEL 5 0363-3890 LOTION 13 g TOPICAL OTC monograph not final 13 sections