homosalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
analgesic anti-inflammatory 3279 118-56-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • homosalate
  • homomenthyl salicylate
  • kemester
cpd not photoallergenic
  • Molecular weight: 262.35
  • Formula: C16H22O3
  • CLOGP: 5.92
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -3.85
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,STK33,TEK,TTK 38
kinase-selectivity-class AXL,BRAF,GRK2,TTK 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 1193.45 28.55 326 7266 37644 90583211
Chronic sinusitis 471.32 28.55 143 7449 23659 90597196
Paraesthesia oral 431.17 28.55 143 7449 31516 90589339
Procedural pain 404.15 28.55 138 7454 33222 90587633
Vaginal flatulence 397.97 28.55 109 7483 12529 90608326
Female genital tract fistula 395.36 28.55 117 7475 17751 90603104
Radiculopathy 378.34 28.55 114 7478 18391 90602464
Proctitis 377.64 28.55 109 7483 15150 90605705
Vaginal discharge 351.46 28.55 109 7483 19355 90601500
Oral candidiasis 287.42 28.55 109 7483 35346 90585509
Haematochezia 238.46 28.55 117 7475 70796 90550059
Colitis ulcerative 237.83 28.55 111 7481 60155 90560700
Frequent bowel movements 237.56 28.55 109 7483 56826 90564029
Colitis 228.03 28.55 113 7479 69829 90551026
Rectal haemorrhage 224.23 28.55 118 7474 82626 90538229
Therapeutic product effect incomplete 209.90 28.55 154 7438 193742 90427113
Dyspepsia 173.98 28.55 139 7453 198021 90422834
Drug ineffective 152.90 28.55 347 7245 1383951 89236904
Constipation 113.24 28.55 128 7464 280267 90340588
Weight decreased 110.64 28.55 147 7445 379763 90241092
Erythema 110.64 28.55 115 7477 229131 90391724
Anaemia 92.79 28.55 130 7462 352672 90268183
Infusion related reaction 90.07 28.55 140 7452 416640 90204215
Abdominal pain 78.68 28.55 128 7464 395593 90225262
Pyrexia 78.17 28.55 171 7421 660314 89960541
Carbuncle 67.31 28.55 17 7575 1419 90619436
Malaise 65.07 28.55 148 7444 585838 90035017
Monoclonal immunoglobulin present 60.71 28.55 17 7575 2107 90618748
Hypothalamo-pituitary disorder 59.73 28.55 17 7575 2235 90618620
Amyloid arthropathy 50.55 28.55 14 7578 1666 90619189
Asthma-chronic obstructive pulmonary disease overlap syndrome 50.49 28.55 18 7574 4881 90615974
Total lung capacity increased 50.06 28.55 18 7574 5003 90615852
Overweight 47.13 28.55 18 7574 5916 90614939
Off label use 46.90 28.55 199 7393 1102053 89518802
Nasal polyps 45.82 28.55 21 7571 10859 90609996
Cholelithiasis 44.15 28.55 36 7556 52470 90568385
Fibrosis 43.51 28.55 17 7575 5935 90614920
Nausea 43.06 28.55 195 7397 1110121 89510734
Wrist deformity 41.50 28.55 14 7578 3224 90617631
Hypomania 40.08 28.55 18 7574 8879 90611976
Nephropathy 39.44 28.55 18 7574 9217 90611638
Jaundice cholestatic 38.00 28.55 18 7574 10025 90610830
Sarcoidosis 36.96 28.55 18 7574 10655 90610200
Bronchiectasis 36.61 28.55 23 7569 22307 90598548
Dyslipidaemia 34.86 28.55 17 7575 10090 90610765
Body height decreased 32.17 28.55 17 7575 11932 90608923
Proctalgia 31.96 28.55 15 7577 8183 90612672
Rhinitis allergic 31.90 28.55 19 7573 16766 90604089
Fatigue 31.87 28.55 30 7562 1153993 89466862
Pulmonary pain 31.80 28.55 13 7579 5101 90615754
Purpura 31.44 28.55 18 7574 14760 90606095
Schizophrenia 31.29 28.55 18 7574 14896 90605959
Renal cyst 30.88 28.55 17 7575 12933 90607922
Pain 29.31 28.55 162 7430 996179 89624676
Dyspnoea 29.22 28.55 19 7573 880936 89739919
Joint swelling 28.84 28.55 4 7588 503296 90117559
Bone density decreased 28.77 28.55 18 7574 17327 90603528

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anal inflammation 164.30 24.54 34 1894 2195 42617212
SARS-CoV-2 test negative 153.97 24.54 31 1897 1744 42617663
Accident 128.09 24.54 34 1894 6469 42612938
Proctalgia 125.16 24.54 34 1894 7059 42612348
Haemorrhoids 91.91 24.54 33 1895 17064 42602343
Body temperature increased 89.90 24.54 34 1894 20324 42599083
Febrile neutropenia 48.04 24.54 50 1878 185653 42433754
Back pain 38.09 24.54 39 1889 141737 42477670
Chills 37.02 24.54 32 1896 94034 42525373
Pyrexia 36.20 24.54 64 1864 393978 42225429
Neutropenia 33.47 24.54 43 1885 199388 42420019
Vomiting 31.78 24.54 51 1877 289672 42329735
Pain 25.31 24.54 42 1886 244806 42374601
Diarrhoea 24.68 24.54 60 1868 460789 42158618

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 504.95 22.15 147 8931 21512 110558709
Chronic sinusitis 458.06 22.15 141 8937 24943 110555278
Paraesthesia oral 417.25 22.15 141 8937 33530 110546691
Female genital tract fistula 402.17 22.15 116 8962 16403 110563818
Vaginal flatulence 399.64 22.15 108 8970 12036 110568185
Procedural pain 390.31 22.15 136 8942 35429 110544792
Radiculopathy 371.26 22.15 113 8965 19223 110560998
Proctitis 364.16 22.15 108 8970 16819 110563402
Vaginal discharge 358.16 22.15 108 8970 17800 110562421
Oral candidiasis 261.40 22.15 108 8970 44652 110535569
Frequent bowel movements 216.07 22.15 109 8969 71281 110508940
Colitis ulcerative 210.66 22.15 110 8968 77253 110502968
Therapeutic product effect incomplete 194.96 22.15 155 8923 223650 110356571
Rectal haemorrhage 190.67 22.15 120 8958 119713 110460508
Colitis 189.72 22.15 113 8965 102210 110478011
Haematochezia 189.63 22.15 118 8960 115406 110464815
Dyspepsia 178.67 22.15 138 8940 190827 110389394
Proctalgia 135.09 22.15 48 9030 13174 110567047
Anal inflammation 134.96 22.15 33 9045 2463 110577758
SARS-CoV-2 test negative 124.26 22.15 30 9048 2123 110578098
Constipation 105.55 22.15 138 8940 357648 110222573
Weight decreased 104.62 22.15 158 8920 467899 110112322
Infusion related reaction 103.23 22.15 141 8937 381021 110199200
Pyrexia 102.16 22.15 226 8852 898039 109682182
Erythema 96.33 22.15 119 8959 291328 110288893
Malaise 91.35 22.15 182 8896 671637 109908584
Accident 86.85 22.15 33 9045 10919 110569302
Carbuncle 67.29 22.15 17 9061 1450 110578771
Anaemia 64.59 22.15 140 8938 546946 110033275
Pain 62.78 22.15 196 8882 954759 109625462
Abdominal pain 62.53 22.15 133 8945 512856 110067365
Monoclonal immunoglobulin present 58.04 22.15 17 9061 2523 110577698
Hypothalamo-pituitary disorder 56.13 22.15 17 9061 2829 110577392
Total lung capacity increased 53.88 22.15 19 9059 5093 110575128
Amyloid arthropathy 50.83 22.15 14 9064 1666 110578555
Asthma-chronic obstructive pulmonary disease overlap syndrome 49.88 22.15 19 9059 6325 110573896
Haemorrhoids 47.50 22.15 32 9046 35640 110544581
Overweight 45.98 22.15 18 9060 6446 110573775
Nasal polyps 45.35 22.15 22 9056 13178 110567043
Wrist deformity 41.98 22.15 14 9064 3175 110577046
Body temperature increased 41.41 22.15 35 9043 54678 110525543
Hypomania 41.16 22.15 19 9059 10191 110570030
Fibrosis 39.73 22.15 17 9061 7625 110572596
Nausea 39.15 22.15 202 8876 1235488 109344733
Cholelithiasis 38.87 22.15 36 9042 63386 110516835
Sarcoidosis 37.39 22.15 19 9059 12560 110567661
Rhinitis allergic 36.32 22.15 21 9057 17901 110562320
Jaundice cholestatic 34.71 22.15 19 9059 14589 110565632
Body height decreased 34.47 22.15 17 9061 10546 110569675
Bronchiectasis 31.07 22.15 25 9053 36468 110543753
Nephropathy 30.58 22.15 17 9061 13450 110566771
Bone density decreased 30.41 22.15 18 9060 16024 110564197
Off label use 30.16 22.15 218 8860 1499967 109080254
Pulmonary pain 29.46 22.15 13 9065 6280 110573941
Dyspnoea 28.95 22.15 29 9049 1106843 109473378
Dyslipidaemia 27.89 22.15 17 9061 15948 110564273
Cardiac murmur 27.88 22.15 20 9058 24608 110555613
Schizophrenia 27.67 22.15 19 9059 21807 110558414
Joint swelling 25.93 22.15 3 9075 442842 110137379
Renal cyst 25.87 22.15 17 9061 18155 110562066
Fatigue 24.37 22.15 39 9039 1215919 109364302
Toxicity to various agents 24.19 22.15 5 9073 480550 110099671
Drug interaction 23.59 22.15 6 9072 500177 110080044
Therapeutic product effect delayed 23.40 22.15 10 9068 4469 110575752
Headache 22.98 22.15 137 8941 882240 109697981

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003879 Dermatologic Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents
MeSH PA D020011 Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.91 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021147 VUID
N0000179485 NUI
D04450 KEGG_DRUG
4021147 VANDF
C0304631 UMLSCUI
CHEBI:749790 CHEBI
CHEMBL1377575 ChEMBL_ID
DB11064 DRUGBANK_ID
C060446 MESH_SUPPLEMENTAL_RECORD_UI
8362 PUBCHEM_CID
3183 INN_ID
V06SV4M95S UNII
91326 RXNORM
001969 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.12 g TOPICAL OTC Monograph Drug 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.12 g TOPICAL OTC Monograph Drug 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.10 g TOPICAL OTC Monograph Drug 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.10 g TOPICAL OTC Monograph Drug 8 sections
SOLBAR THIRTY HUMAN OTC DRUG LABEL 5 0096-0689 GEL 120 mg TOPICAL OTC Monograph Drug 11 sections
SOLBAR SUNSCREEN 35 AVO HUMAN OTC DRUG LABEL 4 0096-0690 CREAM 80 mg TOPICAL OTC Monograph Drug 11 sections
SOLBAR SUNSCREEN 40 ZINC HUMAN OTC DRUG LABEL 3 0096-0691 CREAM 100 mg TOPICAL OTC Monograph Drug 11 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.06 g TOPICAL OTC Monograph Drug 11 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.06 g TOPICAL OTC Monograph Drug 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 95 mg TOPICAL OTC Monograph Drug 13 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 125 mg TOPICAL OTC Monograph Drug 13 sections
Cetaphil Healthy Renew Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4136 LOTION 95 mg TOPICAL OTC Monograph Drug 13 sections
Cetaphil Hydrating Face Sunscreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4142 LOTION 95 mg TOPICAL OTC Monograph Drug 13 sections
Almay Healthy Biome Makeup HUMAN OTC DRUG LABEL 5 0311-0723 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Almay Healthy Biome MakeupFair HUMAN OTC DRUG LABEL 5 0311-0737 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Almay Healthy Biome MakeupLight HUMAN OTC DRUG LABEL 5 0311-0738 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Almay Healthy Biome MakeupMedium HUMAN OTC DRUG LABEL 5 0311-0739 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Almay Healthy Biome MakeupGolden HUMAN OTC DRUG LABEL 5 0311-0740 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Almay Healthy Biome MakeupTan HUMAN OTC DRUG LABEL 5 0311-0741 EMULSION 5 mg TOPICAL OTC Monograph Drug 9 sections
Walgreens SPF 70 Sport Continuous HUMAN OTC DRUG LABEL 4 0363-0035 SPRAY 150 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 55 Sheer Face Mist Sunscreen HUMAN OTC DRUG LABEL 4 0363-0053 SPRAY 1000 mg TOPICAL OTC Monograph Drug 13 sections
Walgreens SPF 50 Clear Complexion Face Sunscreen HUMAN OTC DRUG LABEL 4 0363-0066 LOTION 40 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 30 Sport HUMAN OTC DRUG LABEL 4 0363-0093 LOTION 80 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 50 Sport Continuous Sunscreen HUMAN OTC DRUG LABEL 4 0363-0128 SPRAY 100 mg TOPICAL OTC Monograph Drug 12 sections
WALGREENS SPF 100 SHEER BODY SUNSCREEN MIST HUMAN OTC DRUG LABEL 4 0363-0135 AEROSOL, SPRAY 150 mg TOPICAL OTC Monograph Drug 13 sections
Walgreens SPF 50 Hydrating HUMAN OTC DRUG LABEL 4 0363-0136 LOTION 150 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens SPF 30 Hydrating HUMAN OTC DRUG LABEL 4 0363-0146 LOTION 80 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens Daytime Facial Moisturizer with Broad Spectrum SPF 30 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0187 LOTION 150 mg TOPICAL OTC Monograph Drug 12 sections