hematoporphyrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3274 14459-29-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hematoporphyrin
  • photodyn
Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.
  • Molecular weight: 598.70
  • Formula: C34H38N4O6
  • CLOGP: 5.46
  • LIPINSKI: 3
  • HAC: 10
  • HDO: 6
  • TPSA: 172.42
  • ALOGS: -4.20
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK5,CDK9,CLK4,DDR1,DYRK1B,DYRK3,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,GSK3B,IRAK1,ITK,JAK1,JAK2,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PIM3,PRKDC,SIK2,SIK3,STK17A,STK33,SYK,TEK,TGFBR1,TTK,UHMK1,ULK1 64
kinase-selectivity-class ACVR2B,AXL,BRAF,CAMK2D,CDK16,CLK2,CLK4,EIF2AK3,GRK2,IRAK3,KDR,MAP2K6,MAP3K14,MAP3K7,PDK1,SIK2,STK33,SYK,TEK,ZAP70 20
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003879 Dermatologic Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D017319 Photosensitizing Agents
CHEBI has role CHEBI:47868 photosensitizing agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Non-small cell lung cancer indication 254637007 DOID:3908
Malignant tumor of esophagus indication 363402007
High Grade Dysplasia associated with Barrett's Esophagus indication
Endoscopic Photodynamic Ablation Adjunct for Cancer or High Grade Dysplasia indication
Esophageal varices contraindication 28670008
Ulcer of esophagus contraindication 30811009
Stricture of esophagus contraindication 63305008
Kidney disease contraindication 90708001 DOID:557
Tracheoesophageal fistula contraindication 95435007
Bronchoesophageal fistula contraindication 235641005
Disease of liver contraindication 235856003 DOID:409
Thromboembolic disorder contraindication 371039008
Breastfeeding (mother) contraindication 413712001
Porphyria contraindication 418470004
Tracheal Erosion due to Malignant Esophagus Neoplasm contraindication
Bronchial Erosion due to Malignant Esophagus Neoplasm contraindication
Arterial Erosion by Tumor Growth contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.14 acidic
pKa2 3.76 acidic
pKa3 11.63 acidic
pKa4 13.06 acidic
pKa5 13.28 acidic
pKa6 14.0 acidic
pKa7 5.16 Basic
pKa8 4.25 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C0018959 UMLSCUI
CHEBI:36162 CHEBI
CHEMBL403729 ChEMBL_ID
D006415 MESH_DESCRIPTOR_UI
DB16183 DRUGBANK_ID
HBT6M5H379 UNII
11103 PUBCHEM_CID
5164 RXNORM
005425 NDDF
51462002 SNOMEDCT_US

Pharmaceutical products:

None