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hematoporphyrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3274 | 14459-29-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK5,CDK9,CLK4,DDR1,DYRK1B,DYRK3,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,GSK3B,IRAK1,ITK,JAK1,JAK2,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PIM3,PRKDC,SIK2,SIK3,STK17A,STK33,SYK,TEK,TGFBR1,TTK,UHMK1,ULK1 | 64 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CAMK2D,CDK16,CLK2,CLK4,EIF2AK3,GRK2,IRAK3,KDR,MAP2K6,MAP3K14,MAP3K7,PDK1,SIK2,STK33,SYK,TEK,ZAP70 | 20 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D011838 | Radiation-Sensitizing Agents |
| MeSH PA | D017319 | Photosensitizing Agents |
| CHEBI has role | CHEBI:47868 | photosensitizing agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
| Malignant tumor of esophagus | indication | 363402007 | |
| High Grade Dysplasia associated with Barrett's Esophagus | indication | ||
| Endoscopic Photodynamic Ablation Adjunct for Cancer or High Grade Dysplasia | indication | ||
| Esophageal varices | contraindication | 28670008 | |
| Ulcer of esophagus | contraindication | 30811009 | |
| Stricture of esophagus | contraindication | 63305008 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Tracheoesophageal fistula | contraindication | 95435007 | |
| Bronchoesophageal fistula | contraindication | 235641005 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Thromboembolic disorder | contraindication | 371039008 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Porphyria | contraindication | 418470004 | |
| Tracheal Erosion due to Malignant Esophagus Neoplasm | contraindication | ||
| Bronchial Erosion due to Malignant Esophagus Neoplasm | contraindication | ||
| Arterial Erosion by Tumor Growth | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.14 | acidic |
| pKa2 | 3.76 | acidic |
| pKa3 | 11.63 | acidic |
| pKa4 | 13.06 | acidic |
| pKa5 | 13.28 | acidic |
| pKa6 | 14.0 | acidic |
| pKa7 | 5.16 | Basic |
| pKa8 | 4.25 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| C0018959 | UMLSCUI |
| CHEBI:36162 | CHEBI |
| CHEMBL403729 | ChEMBL_ID |
| D006415 | MESH_DESCRIPTOR_UI |
| DB16183 | DRUGBANK_ID |
| HBT6M5H379 | UNII |
| 11103 | PUBCHEM_CID |
| 5164 | RXNORM |
| 005425 | NDDF |
| 51462002 | SNOMEDCT_US |
Pharmaceutical products:
None