gabexate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
gabamimetic agents 3257 39492-01-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gabexate
  • gabexate mesilate
  • gabexate mesylate
A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
  • Molecular weight: 321.38
  • Formula: C16H23N3O4
  • CLOGP: 2.43
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 114.50
  • ALOGS: -3.47
  • ROTB: 11

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 12 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000925 Anticoagulants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006401 Hematologic Agents
MeSH PA D011480 Protease Inhibitors
MeSH PA D015842 Serine Proteinase Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.79 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Urokinase-type plasminogen activator Enzyme IC50 6.37 CHEMBL
Plasminogen Enzyme IC50 5.81 CHEMBL
Prothrombin Enzyme IC50 6.16 CHEMBL
Coagulation factor X Enzyme IC50 5.34 CHEMBL
Tissue-type plasminogen activator Enzyme IC50 4.81 CHEMBL
Plasma kallikrein Enzyme IC50 5.87 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 6.05 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 6.30 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 4.97 CHEMBL
Tryptase alpha/beta-1 Enzyme INHIBITOR IC50 8.47 IUPHAR
Serine protease hepsin Enzyme IC50 6.42 CHEMBL
Coagulation factor XII Enzyme Ki 5.54 CHEMBL
Membrane primary amine oxidase Enzyme Ki 4.57 CHEMBL

External reference:

IDSource
D01672 KEGG_DRUG
C0085231 UMLSCUI
CHEBI:31641 CHEBI
CHEMBL87563 ChEMBL_ID
DB12831 DRUGBANK_ID
D016670 MESH_DESCRIPTOR_UI
3447 PUBCHEM_CID
7863 IUPHAR_LIGAND_ID
3988 INN_ID
56974-61-9 SECONDARY_CAS_RN
4V7M9137X9 UNII

Pharmaceutical products:

None