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gabexate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| gabamimetic agents | 3257 | 39492-01-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 12 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHA2,EPHB4,ERBB2,FGFR1,FLT3,GRK2,GSK3B,IGF1R,IKBKB,IRAK1,ITK,JAK1,JAK2,JAK3,KIT,MAP2K1,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 | 77 | |||
| kinase-selectivity-class | AXL,EIF2AK3,GRK2,MAPK7,STK33,TEK | 6 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000925 | Anticoagulants |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D011480 | Protease Inhibitors |
| MeSH PA | D015842 | Serine Proteinase Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.79 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Urokinase-type plasminogen activator | Enzyme | IC50 | 6.37 | CHEMBL | |||||
| Plasminogen | Enzyme | IC50 | 5.81 | CHEMBL | |||||
| Prothrombin | Enzyme | IC50 | 6.16 | CHEMBL | |||||
| Coagulation factor X | Enzyme | IC50 | 5.34 | CHEMBL | |||||
| Tissue-type plasminogen activator | Enzyme | IC50 | 4.81 | CHEMBL | |||||
| Plasma kallikrein | Enzyme | IC50 | 5.87 | CHEMBL | |||||
| Solute carrier family 22 member 2 | Transporter | IC50 | 6.05 | CHEMBL | |||||
| Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 6.30 | CHEMBL | |||||
| Multidrug and toxin extrusion protein 2 | Transporter | IC50 | 4.97 | CHEMBL | |||||
| Tryptase alpha/beta-1 | Enzyme | INHIBITOR | IC50 | 8.47 | IUPHAR | ||||
| Serine protease hepsin | Enzyme | IC50 | 6.42 | CHEMBL | |||||
| Transmembrane protease serine 2 | Enzyme | IC50 | 6.89 | CHEMBL | |||||
| Coagulation factor XII | Enzyme | Ki | 5.54 | CHEMBL | |||||
| Membrane primary amine oxidase | Enzyme | Ki | 4.57 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01672 | KEGG_DRUG |
| C0085231 | UMLSCUI |
| CHEBI:748372 | CHEBI |
| CHEMBL87563 | ChEMBL_ID |
| DB12831 | DRUGBANK_ID |
| D016670 | MESH_DESCRIPTOR_UI |
| 3447 | PUBCHEM_CID |
| 7863 | IUPHAR_LIGAND_ID |
| 3988 | INN_ID |
| 56974-61-9 | SECONDARY_CAS_RN |
| 4V7M9137X9 | UNII |
| 4V7M9137X9 | INXIGHT DRUGS |
Pharmaceutical products:
None