fospropofol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
insecticides, anthelminthics, pesticides etc., phosphorous derivatives	3249	258516-89-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

fospropofol sodium
fospropofol
fospropofol disodium
lusedra

Molecular weight: 288.28
Formula: C13H21O5P
CLOGP: 1.73
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 75.99
ALOGS: -2.98
ROTB: 6

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Dec. 12, 2008	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D006993	Hypnotics and Sedatives

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Sedation as Adjunct to Anesthesia	indication
Apnea	contraindication	1023001
Hypovolemia	contraindication	28560003
Low blood pressure	contraindication	45007003
Decreased respiratory function	contraindication	80954004
Myocardial dysfunction	contraindication	233928007
Hypoxia	contraindication	389086002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.39	acidic
pKa2	7.44	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor	Ion channel	O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 Q16445 Q8N1C3 Q99928	GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN	POSITIVE ALLOSTERIC MODULATOR				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
4028230	VUID
N0000177942	NUI
D04257	KEGG_DRUG
258516-87-9	SECONDARY_CAS_RN
4028230	VANDF
4028231	VANDF
C2370726	UMLSCUI
CHEBI:135193	CHEBI
CHEMBL1201766	ChEMBL_ID
CHEMBL2021422	ChEMBL_ID
DB06716	DRUGBANK_ID
C472965	MESH_SUPPLEMENTAL_RECORD_UI
3038498	PUBCHEM_CID
7475	IUPHAR_LIGAND_ID
8696	INN_ID
LZ257RZP7K	UNII
813021	RXNORM
159531	MMSL
26076	MMSL
d07370	MMSL
013314	NDDF
013315	NDDF
714706007	SNOMEDCT_US
764594003	SNOMEDCT_US

Pharmaceutical products:

None