femoxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 3220 | 59859-58-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
serotonin uptake inhibitor; RN given refers to (3R-trans)-isomer
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 8 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D017367 | Selective Serotonin Reuptake Inhibitors |
| MeSH PA | D018490 | Serotonin Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.04 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | GPCR | Ki | 6.23 | PDSP | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 7.96 | PDSP | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Ki | 6.12 | PDSP | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.64 | PDSP | |||||
| Histamine H1 receptor | GPCR | Ki | 5.38 | PDSP | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.04 | PDSP | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.82 | PDSP | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | Ki | 6.66 | PDSP | |||||
| Muscarinic acetylcholine receptor M4 | GPCR | Ki | 6.33 | PDSP | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 6.40 | PDSP | |||||
| Sodium-dependent dopamine transporter | Transporter | Ki | 5.69 | PDSP | |||||
| Sodium-dependent dopamine transporter | Transporter | Ki | 8.04 | CHEMBL | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Ki | 6.92 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C0060145 | UMLSCUI |
| CHEMBL94739 | ChEMBL_ID |
| C010655 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3012003 | PUBCHEM_CID |
| 4032 | INN_ID |
| 8Y719ZLX8C | UNII |
Pharmaceutical products:
None