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ensulizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3179 | 27503-81-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
sunscreening agent
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -0.387 | Moderate | 0.67 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 11.940 | Moderate | 0.67 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 1.734 | 10^-6 cm/s | Moderate | 0.67 |
| dh-clint | Dog hepatocyte intrinsic clearance | 1.479 | uL/min/10^6 cells | Moderate | 0.67 |
| dppb | Dog plasma protein binding (% unbound) | 4.470 | % | Moderate | 0.67 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 7.600 | % | Moderate | 0.67 |
| herg | hERG pIC50 | 4.253 | pIC50 | Moderate | 0.67 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.074 | uL/min/10^6 cells | Moderate | 0.67 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.083 | uL/min/mg protein | Moderate | 0.67 |
| hppb | Human plasma protein binding (% unbound) | 1.470 | % | Moderate | 0.67 |
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,IRAK1,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2 | 63 | |||
| kinase-selectivity-class | DYRK1B,GRK2,MAP2K6,MAPK7,STK33,TTK | 6 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.998 | Moderate | 0.67 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 2.037 | Moderate | 0.67 | |
| mppb | Mouse plasma protein binding (% unbound) | 15.460 | Moderate | 0.67 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.251 | Moderate | 0.67 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 4.660 | % | Moderate | 0.67 |
| rh-clint | Rat hepatocyte intrinsic clearance | 1.545 | uL/min/10^6 cells | Moderate | 0.67 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 85.630 | % | Moderate | 0.67 |
| rppb | Rat plasma protein binding (% unbound) | 2.890 | % | Moderate | 0.67 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 984.011 | uM | Moderate | 0.67 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Sunscreen agent | indication | 49663007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.87 | acidic |
| pKa2 | 0.28 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Histone deacetylase 6 | Enzyme | IC50 | 5.63 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020576 | VUID |
| N0000179016 | NUI |
| D10005 | KEGG_DRUG |
| 4020576 | VANDF |
| C0046519 | UMLSCUI |
| CHEBI:135132 | CHEBI |
| CHEMBL1987518 | ChEMBL_ID |
| DB11115 | DRUGBANK_ID |
| C499767 | MESH_SUPPLEMENTAL_RECORD_UI |
| 33919 | PUBCHEM_CID |
| 7995 | INN_ID |
| 9YQ9DI1W42 | UNII |
| 13714 | RXNORM |
| 005207 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| g and h Protect Body | HUMAN OTC DRUG LABEL | 3 | 10056-025 | LOTION | 17 mg | TOPICAL | OTC Monograph Drug | 13 sections |
| Artistry Ideal Radiance Illuminating CC SPF50 Broad Spectrum Sunscreen - Light | HUMAN OTC DRUG LABEL | 5 | 10056-030 | CREAM | 20 mg | TOPICAL | OTC Monograph Drug | 11 sections |
| Eucerin Daily Protection Face | HUMAN OTC DRUG LABEL | 5 | 10356-323 | LOTION | 2 g | TOPICAL | OTC Monograph Drug | 12 sections |
| No7 Rebalancing Day Fluid Sunscreen SPF 15 | HUMAN OTC DRUG LABEL | 3 | 11489-069 | LOTION | 2 mL | TOPICAL | OTC monograph not final | 12 sections |
| FUTURIST HYDRA RESCUE MOISTURIZING MAKEUP BROAD SPECTRUM SPF 45 | HUMAN OTC DRUG LABEL | 4 | 11559-058 | LIQUID | 27 mg | TOPICAL | OTC Monograph Drug | 13 sections |
| Aloe Sunscreen | HUMAN OTC DRUG LABEL | 5 | 11697-199 | LOTION | 3 g | TOPICAL | OTC monograph not final | 12 sections |
| Aloe Sunscreen | HUMAN OTC DRUG LABEL | 5 | 11697-319 | SPRAY | 4 g | TOPICAL | OTC monograph not final | 12 sections |
| Advanced Firming and Anti Wrinkle | HUMAN OTC DRUG LABEL | 2 | 11822-0378 | CREAM | 2 g | TOPICAL | OTC monograph not final | 11 sections |
| Age Perfecting SPF 15 Sunscreen Daylogic | HUMAN OTC DRUG LABEL | 2 | 11822-2222 | CREAM | 1.70 g | TOPICAL | OTC monograph not final | 6 sections |
| RITE AID RENEWALSUNSCREEN | HUMAN OTC DRUG LABEL | 4 | 11822-3410 | LOTION | 2 mL | TOPICAL | OTC monograph not final | 11 sections |
| Daylogic Tinted Daily Moisturizer SPF 30 | HUMAN OTC DRUG LABEL | 4 | 11822-3430 | LOTION | 20 mg | TOPICAL | OTC monograph not final | 13 sections |
| LBEL REGRESSION JOUR Protective Complex with SPF 15 Facial day normal to dry skin | HUMAN OTC DRUG LABEL | 4 | 13537-025 | CREAM | 0.01 g | TOPICAL | OTC MONOGRAPH NOT FINAL | 13 sections |
| MISSHA ALL AROUND SAFE BLOCK ESSENCE SUNSPF45 PA PLUS PLUS PLUS | HUMAN OTC DRUG LABEL | 3 | 13733-014 | CREAM | 2 mL | CUTANEOUS | OTC monograph final | 8 sections |
| LBEL REGRESSION JOUR Protective Complex with SPF 15 Facial day normal to dry skin | HUMAN OTC DRUG LABEL | 4 | 14783-025 | CREAM | 0.01 g | TOPICAL | OTC MONOGRAPH NOT FINAL | 13 sections |
| LBel Paris Regression Jour | HUMAN OTC DRUG LABEL | 4 | 14783-039 | CREAM | 0.05 g | TOPICAL | OTC MONOGRAPH FINAL | 11 sections |
| LBel Paris Regression Jour | HUMAN OTC DRUG LABEL | 4 | 14783-049 | CREAM | 0.50 g | TOPICAL | OTC MONOGRAPH FINAL | 11 sections |
| Rayito de Sol | HUMAN OTC DRUG LABEL | 2 | 20367-132 | GEL | 4 g | TOPICAL | OTC monograph final | 14 sections |
| Rayito de Sol | HUMAN OTC DRUG LABEL | 2 | 20367-133 | GEL | 4 g | TOPICAL | OTC monograph final | 13 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 805 Ivory | HUMAN OTC DRUG LABEL | 1 | 22700-127 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 810 Classic Ivory | HUMAN OTC DRUG LABEL | 1 | 22700-128 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 820 Creamy Natural | HUMAN OTC DRUG LABEL | 1 | 22700-129 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 825 Buff Beige | HUMAN OTC DRUG LABEL | 1 | 22700-130 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 832 Nude Beige | HUMAN OTC DRUG LABEL | 1 | 22700-131 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 840 Natural Beige | HUMAN OTC DRUG LABEL | 1 | 22700-132 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 842 Medium Beige | HUMAN OTC DRUG LABEL | 1 | 22700-133 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 845 Warm Beige | HUMAN OTC DRUG LABEL | 1 | 22700-134 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 850 Creamy Beige | HUMAN OTC DRUG LABEL | 1 | 22700-135 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 855 Soft Honey | HUMAN OTC DRUG LABEL | 1 | 22700-136 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 857 Golden Tan | HUMAN OTC DRUG LABEL | 1 | 22700-137 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |
| Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 860 Classic Tan | HUMAN OTC DRUG LABEL | 1 | 22700-138 | LIQUID | 0.03 mg | TOPICAL | OTC monograph not final | 14 sections |