ecamsule 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3171 92761-26-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Mexoryl SX
  • ecamsule
an organic chemical agent capable of absorbing light throughout the entire UVA spectrum
  • Molecular weight: 562.69
  • Formula: C28H34O8S2
  • CLOGP: 1.56
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 2
  • TPSA: 142.88
  • ALOGS: -4.99
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MAPKAPK5,NTRK2,PDK1,PDK2,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 50
kinase-selectivity-class ACVR2B,AURKA,AURKC,AXL,BMX,BRAF,CDK4,CDK6,CDK9,CHUK,EPHB4,ERBB2,GRK2,JAK2,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAPK7,MST1R,NTRK3,PIK3CD,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TYRO3,ZAP70 30
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
July 21, 2006 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003879 Dermatologic Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents
MeSH PA D020011 Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.08 acidic
pKa2 0.68 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03932 KEGG_DRUG
C1721194 UMLSCUI
CHEBI:135830 CHEBI
CHEMBL3989850 ChEMBL_ID
DB09534 DRUGBANK_ID
C075352 MESH_SUPPLEMENTAL_RECORD_UI
7518 INN_ID
M94R1PM439 UNII
146382 PUBCHEM_CID
1544124 RXNORM
422419003 SNOMEDCT_US
425235001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Garnier Ombrelle SPF 30 Complete Lightweight HUMAN OTC DRUG LABEL 6 49967-012 LOTION 5 mg TOPICAL export only 5 sections
Garnier Ombrelle SPF 60 Complete Lightweight HUMAN OTC DRUG LABEL 6 49967-081 LOTION 5 mg TOPICAL export only 5 sections
Kiehls Activated Sun Protector Sunscreen SPF 50 For Face and Body For All Skin Types HUMAN OTC DRUG LABEL 7 49967-123 LOTION 30 mg TOPICAL export only 4 sections
Kiehls Ultra Light Daily UV Defense CC SPF 50 Anti Pollution HUMAN OTC DRUG LABEL 6 49967-161 CREAM 120 mg TOPICAL export only 4 sections
Kiehls Ultra Light Daily UV Defense Sunscreen HUMAN OTC DRUG LABEL 3 49967-258 LOTION 120 mg TOPICAL export only 3 sections
Kiehls Activated Sun Protector Sunscreen SPF 30 For Face and Body For All Skin Types HUMAN OTC DRUG LABEL 7 49967-309 LOTION 30 mg TOPICAL export only 4 sections
KIEHLS DERMATOLOGIST SOLUTIONS ULTRA LIGHT DAILY UV DEFENSE SUNSCREEN SPF 50 HIGH PROTECTION ANTI-POLLUTION LIGHTWEIGHT FORMULA FOR ALL SKIN TYPES HUMAN OTC DRUG LABEL 6 49967-449 LOTION 120 mg TOPICAL export only 4 sections
Garnier Ombrelle SPF 30 Sport Water Resistant HUMAN OTC DRUG LABEL 4 49967-565 LOTION 5 mg TOPICAL export only 5 sections
KIEHLS ULTRA LIGHT DAILY UV DEFENSE TONE UP SPF 50 ANTI POLLUTION INSTANTLY BRIGHTENS AND HYDRATES HUMAN OTC DRUG LABEL 3 49967-762 CREAM 39.60 mg TOPICAL export only 2 sections
Garnier Ombrelle SPF 60 Face Ultra Light HUMAN OTC DRUG LABEL 5 49967-813 LOTION 30 mg TOPICAL export only 5 sections
P.CALM Water Barrier Suncream HUMAN OTC DRUG LABEL 5 83735-001 CREAM 26.40 mg TOPICAL unapproved drug other 7 sections