domitroban 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
thromboxane A2-receptor antagonists; antithrombotic agents 3165 112966-96-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • domitroban
  • domitroban calcium
  • domitroban calcium hydrate
  • Molecular weight: 377.50
  • Formula: C20H27NO4S
  • CLOGP: 4.49
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 83.47
  • ALOGS: -4.99
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.79 acidic
pKa2 9.43 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thromboxane A2 receptor GPCR ANTAGONIST Ki 9.60 IUPHAR
Thromboxane A2 receptor GPCR ANTAGONIST Ki 9.20 IUPHAR

External reference:

IDSource
D09824 KEGG_DRUG
C1880393 UMLSCUI
CHEBI:135586 CHEBI
CHEMBL3301671 ChEMBL_ID
5312138 PUBCHEM_CID
1979 IUPHAR_LIGAND_ID
7348 INN_ID
742F5K270Q UNII

Pharmaceutical products:

None