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demoxytocin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| oxytocin derivatives | 3126 | 113-78-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
octa-peptide lacking free amino group on cystine residue; RN given refers to cpd without isomeric designation
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 100 | U | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | CDK5,CDK9,EIF2AK3,GRK2,PDK1,PDK2,PDK4,PRKDC | 8 | |||
| kinase-selectivity-class | GRK2,PDK1 | 2 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 1.191 | Moderate | 0.75 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | H01BB01 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES POSTERIOR PITUITARY LOBE HORMONES Oxytocin and analogues |
| MeSH PA | D010120 | Oxytocics |
| MeSH PA | D012102 | Reproductive Control Agents |
| CHEBI has role | CHEBI:36063 | oxytocic |
Related Drugs by ATC class:
H01BB Oxytocin and analogues 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.65 | acidic |
| pKa2 | 12.59 | acidic |
| pKa3 | 13.04 | acidic |
| pKa4 | 13.2 | acidic |
| pKa5 | 13.46 | acidic |
| pKa6 | 13.84 | acidic |
| pKa7 | 13.89 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Oxytocin receptor | GPCR | Ki | 9.05 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07228 | KEGG_DRUG |
| C0057218 | UMLSCUI |
| CHEBI:135900 | CHEBI |
| CHEMBL435716 | ChEMBL_ID |
| DB13798 | DRUGBANK_ID |
| C004748 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2685 | INN_ID |
| 2N9HM3X95F | UNII |
| 449224 | PUBCHEM_CID |
Pharmaceutical products:
None