cloxiquine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 3114 130-16-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cloxyquin
  • 5-Chlorooxine
  • 8-Hydroxy-5-chloroquinoline
  • cloxiquine
  • dermofongin
  • dermofungin
has antitubercular activity
  • Molecular weight: 179.60
  • Formula: C9H6ClNO
  • CLOGP: 2.91
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 33.12
  • ALOGS: -2.33
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.28 acidic
pKa2 3.74 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Methionine aminopeptidase 2 Enzyme IC50 5.90 CHEMBL
Methionine aminopeptidase 1 Enzyme IC50 4.89 CHEMBL
Catechol O-methyltransferase Enzyme IC50 4.63 CHEMBL

External reference:

IDSource
D03572 KEGG_DRUG
BPF36H1G6S UNII
3428 INN_ID
2817 PUBCHEM_CID
CHEBI:134818 CHEBI
CHEMBL225164 ChEMBL_ID
C519493 MESH_SUPPLEMENTAL_RECORD_UI
006732 NDDF

Pharmaceutical products:

None