All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

choline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	3097	62-49-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: choline chloride choline vitamin J bilineurine choline ion choline bitartrate	A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. Molecular weight: 104.17 Formula: C5H14NO CLOGP: -4.36 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 20.23 ALOGS: -1.59 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	-4.397		High	1
caco2-efflux	Caco-2 efflux ratio (BA/AB)	0.042		High	1
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	0.493	10^-6 cm/s	High	1
dh-clint	Dog hepatocyte intrinsic clearance	3.483	uL/min/10^6 cells	High	1
dppb	Dog plasma protein binding (% unbound)	84.300	%	High	1
fcs-ppb	Fetal calf serum protein binding (% unbound)	33.640	%	High	1
herg	hERG pIC50	3.917	pIC50	High	1
hh-clint	Human hepatocyte intrinsic clearance	1.524	uL/min/10^6 cells	High	1
hlm-clint	Human liver microsomal intrinsic clearance	2.472	uL/min/mg protein	High	1
hppb	Human plasma protein binding (% unbound)	84.510	%	High	1
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1	54
kinase-selectivity-class	ACVR2B,AXL,BRAF,CAMK2D,CDK1,CDK4,DDR1,FLT3,GRK2,MAPK7	10
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	0.041		High	1
mh-clint	Mouse hepatocyte intrinsic clearance	2.704		High	1
mppb	Mouse plasma protein binding (% unbound)	94.350		High	1
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	0.128		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	83.620	%	High	1
rh-clint	Rat hepatocyte intrinsic clearance	1.799	uL/min/10^6 cells	High	1
rh-fuinc	Rat hepatocyte fraction unbound in incubation	92.870	%	High	1
rppb	Rat plasma protein binding (% unbound)	94.620	%	High	1
solubility-dd	Solubility at pH 7.4 in DMSO	920.450	uM	High	1

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Synovitis	133.64	11.73	3	40694	329749	90258001
Diarrhoea	114.35	11.73	766	39931	938424	89649326
Product use in unapproved indication	114.09	11.73	10	40687	336226	90251524
Product dose omission issue	112.98	11.73	337	40360	291350	90296400
Systemic lupus erythematosus	112.04	11.73	15	40682	361881	90225869
Glossodynia	105.39	11.73	11	40686	321768	90265982
Pericarditis	103.83	11.73	4	40693	270147	90317603
Treatment failure	97.97	11.73	11	40686	303917	90283833
Maternal exposure during pregnancy	92.14	11.73	24	40673	360039	90227711
Infusion related reaction	92.10	11.73	36	40661	416744	90171006
Wound	90.40	11.73	14	40683	302966	90284784
Fall	90.02	11.73	441	40256	481369	90106381
Off label use	88.03	11.73	232	40465	1102020	89485730
Drug intolerance	85.99	11.73	47	40650	447544	90140206
Helicobacter infection	85.04	11.73	4	40693	226846	90360904
Product use issue	84.39	11.73	22	40675	329897	90257853
Unevaluable event	79.34	11.73	110	40587	54738	90533012
Folliculitis	75.33	11.73	4	40693	204349	90383401
Device expulsion	74.70	11.73	92	40605	40794	90546956
Fatigue	70.60	11.73	809	39888	1153214	89434536
Hepatic enzyme increased	63.47	11.73	42	40655	360694	90227056
Lower respiratory tract infection	61.67	11.73	18	40679	250641	90337109
Arthropathy	60.03	11.73	46	40651	366196	90221554
Full blood count decreased	59.46	11.73	70	40627	29619	90558131
Type 2 diabetes mellitus	59.24	11.73	10	40687	203234	90384516
Feeling abnormal	58.86	11.73	187	40510	167048	90420702
Deep vein thrombosis	58.51	11.73	128	40569	91492	90496258
Intentional product use issue	58.30	11.73	13	40684	216879	90370871
Muscle spasms	56.91	11.73	244	40453	251639	90336111
Nausea	56.84	11.73	753	39944	1109563	89478187
Liver injury	55.37	11.73	6	40691	170561	90417189
Device dislocation	54.56	11.73	69	40628	31413	90556337
Therapeutic product effect decreased	52.03	11.73	30	40667	277541	90310209
Neuropathy peripheral	51.74	11.73	157	40540	136813	90450937
Therapy cessation	51.20	11.73	72	40625	36289	90551461
Drug hypersensitivity	50.92	11.73	81	40616	463528	90124222
Irritable bowel syndrome	50.84	11.73	15	40682	207433	90380317
Drug ineffective	49.54	11.73	392	40305	1383906	89203844
General physical health deterioration	49.34	11.73	52	40645	355063	90232687
C-reactive protein increased	48.49	11.73	11	40686	181378	90406372
Dizziness	48.22	11.73	439	40258	588845	89998905
Haemoglobin decreased	48.04	11.73	171	40526	161785	90425965
Therapeutic product effect incomplete	47.55	11.73	14	40683	193882	90393868
Fibromyalgia	42.03	11.73	20	40677	206249	90381501
Constipation	41.54	11.73	241	40456	280154	90307596
Plasma cell myeloma	40.82	11.73	69	40628	40759	90546991
Blister	40.53	11.73	33	40664	254965	90332785
Dehydration	39.84	11.73	183	40514	194264	90393486
Ill-defined disorder	39.12	11.73	17	40680	184874	90402876
Back pain	39.08	11.73	260	40437	316915	90270835
Impaired healing	38.88	11.73	29	40668	234170	90353580
Asthenia	37.89	11.73	386	40311	533365	90054385
Flatulence	37.55	11.73	67	40630	41300	90546450
Discomfort	36.08	11.73	42	40655	274293	90313457
Joint swelling	35.54	11.73	112	40585	503188	90084562
Toxicity to various agents	34.79	11.73	47	40650	287799	90299951
Psoriasis	34.79	11.73	145	40552	147609	90440141
Joint range of motion decreased	34.73	11.73	9	40688	135634	90452116
Pulmonary embolism	34.49	11.73	133	40564	130687	90457063
Urinary tract infection	34.36	11.73	245	40452	305387	90282363
Pneumonia	33.84	11.73	436	40261	637623	89950127
Headache	33.74	11.73	559	40138	862187	89725563
Prescribed overdose	32.81	11.73	3	40694	97622	90490128
Bursitis	31.38	11.73	10	40687	131644	90456106
Intentional overdose	31.23	11.73	3	40694	93831	90493919
Hot flush	30.21	11.73	76	40621	59412	90528338
Injection site pain	29.51	11.73	155	40542	173544	90414206
Injection site erythema	28.34	11.73	103	40594	98399	90489351
Exposure during pregnancy	27.73	11.73	40	40657	238370	90349380
Wheezing	27.64	11.73	40	40657	238040	90349710
Influenza like illness	27.30	11.73	89	40608	80522	90507228
Injection site haemorrhage	27.17	11.73	47	40650	28271	90559479
Pelvic pain	27.15	11.73	34	40663	15323	90572427
Obesity	27.01	11.73	7	40690	105500	90482250
Tremor	26.93	11.73	138	40559	153035	90434715
Asthma	26.84	11.73	42	40655	242118	90345632
Rheumatoid arthritis	26.78	11.73	79	40618	362535	90225215
Grip strength decreased	26.00	11.73	5	40692	92571	90495179
Hip fracture	25.56	11.73	50	40647	33027	90554723
Wound infection	25.50	11.73	8	40689	106394	90481356
Laboratory test abnormal	25.05	11.73	57	40640	41797	90545953
Peripheral venous disease	24.73	11.73	4	40693	83917	90503833
Atrial fibrillation	24.63	11.73	122	40575	133489	90454261
Hypersensitivity	24.43	11.73	113	40584	454564	90133186
Sleep disorder	24.26	11.73	32	40665	197998	90389752
Blood potassium decreased	24.26	11.73	61	40636	47666	90540084
Dyspnoea	24.21	11.73	541	40156	880414	89707336
Skin discolouration	23.96	11.73	58	40639	44257	90543493
Mobility decreased	23.72	11.73	48	40649	250686	90337064
White blood cell count decreased	23.66	11.73	142	40555	166967	90420783
Blood cholesterol increased	23.12	11.73	36	40661	207976	90379774
COVID-19	23.11	11.73	25	40672	168818	90418932
Nasal congestion	22.97	11.73	86	40611	83328	90504422
Vaginal haemorrhage	22.64	11.73	46	40651	31225	90556525
Hypervolaemia	22.32	11.73	47	40650	32710	90555040
Eye swelling	22.20	11.73	44	40653	29342	90558408
Alopecia	22.13	11.73	131	40566	494940	90092810
Epilepsy	21.93	11.73	5	40692	82201	90505549
Gastrointestinal disorder	21.92	11.73	52	40645	256635	90331115
Balance disorder	21.85	11.73	94	40603	96986	90490764
Cardiac failure congestive	21.79	11.73	95	40602	98599	90489151
Pulmonary arterial hypertension	20.74	11.73	40	40657	26147	90561603
Live birth	20.73	11.73	5	40692	79102	90508648
Thrombosis	20.56	11.73	76	40621	73175	90514575
Vision blurred	20.53	11.73	101	40596	110192	90477558
Pulmonary hypertension	20.22	11.73	53	40644	42470	90545280
Infection	20.03	11.73	89	40608	362005	90225745
Fluid retention	19.60	11.73	85	40612	88006	90499744
Hypoxia	19.40	11.73	74	40623	72325	90515425
Chills	19.23	11.73	113	40584	131868	90455882
Platelet count decreased	19.14	11.73	116	40581	136853	90450897
Dry skin	18.85	11.73	84	40613	87989	90499761
Multiple sclerosis relapse	18.85	11.73	59	40638	52246	90535504
Overdose	18.79	11.73	26	40671	157683	90430067
Dysgeusia	18.67	11.73	59	40638	52501	90535249
Dyspnoea exertional	18.64	11.73	73	40624	72215	90515535
Lung disorder	18.58	11.73	24	40673	149859	90437891
Autoimmune disorder	17.98	11.73	6	40691	76738	90511012
Product complaint	17.92	11.73	26	40671	13474	90574276
Condition aggravated	17.90	11.73	176	40521	595369	89992381
Flushing	17.89	11.73	83	40614	88408	90499342
Adverse event	17.66	11.73	16	40681	117402	90470348
International normalised ratio increased	17.63	11.73	54	40643	47262	90540488
Swelling	17.62	11.73	113	40584	418945	90168805
Inflammation	17.05	11.73	34	40663	178558	90409192
Pulmonary fibrosis	16.96	11.73	14	40683	107489	90480261
Pleural effusion	16.38	11.73	96	40601	111895	90475855
Bone pain	16.31	11.73	63	40634	61920	90525830
Oedema peripheral	16.13	11.73	182	40515	257733	90330017
Stomatitis	16.12	11.73	66	40631	274632	90313118
Myalgia	16.09	11.73	134	40563	174991	90412759
Tooth disorder	16.07	11.73	40	40657	31050	90556700
Hypertension	16.03	11.73	130	40567	457402	90130348
Body height decreased	15.85	11.73	23	40674	11926	90575824
Cellulitis	15.84	11.73	82	40615	91255	90496495
Suicide attempt	15.83	11.73	7	40690	75392	90512358
Injection site mass	15.41	11.73	32	40665	22058	90565692
Gallbladder disorder	15.38	11.73	30	40667	19773	90567977
Red blood cell sedimentation rate increased	15.35	11.73	9	40688	82586	90505164
Administration site swelling	15.01	11.73	9	40688	1490	90586260
Hospice care	14.84	11.73	20	40677	9684	90578066
Red blood cell count decreased	14.64	11.73	50	40647	46301	90541449
Pollakiuria	14.54	11.73	40	40657	32965	90554785
Injection site bruising	14.45	11.73	54	40643	52253	90535497
Hypophagia	14.32	11.73	42	40655	35895	90551855
Swelling face	14.09	11.73	73	40624	81279	90506471
Depression	14.07	11.73	201	40496	300400	90287350
Burning sensation	13.94	11.73	61	40636	63391	90524359
Plasma cell myeloma recurrent	13.91	11.73	13	40684	4215	90583535
Anaemia	13.86	11.73	229	40468	352573	90235177
Intestinal dilatation	13.70	11.73	10	40687	2300	90585450
Abdominal discomfort	13.53	11.73	143	40554	477185	90110565
Drug interaction	13.51	11.73	71	40626	276382	90311368
Heavy menstrual bleeding	13.46	11.73	29	40668	20501	90567249
Cardiac pacemaker insertion	13.45	11.73	13	40684	4394	90583356
Lethargy	13.34	11.73	60	40637	63079	90524671
Epistaxis	13.12	11.73	74	40623	85051	90502699
Multiple allergies	13.07	11.73	24	40673	15122	90572628
Injection site reaction	12.87	11.73	78	40619	92002	90495748
Pain in jaw	12.81	11.73	49	40648	47936	90539814
Restless legs syndrome	12.78	11.73	30	40667	22440	90565310
Drug-induced liver injury	12.78	11.73	13	40684	90305	90497445
Abdominal pain	12.77	11.73	249	40448	395472	90192278
Night sweats	12.73	11.73	24	40673	128742	90459008
Intermenstrual bleeding	12.59	11.73	18	40679	9205	90578545
Illness	12.53	11.73	11	40686	81958	90505792
Liver disorder	12.53	11.73	22	40675	121247	90466503
Bronchitis	12.48	11.73	114	40583	152813	90434937
Pulmonary oedema	12.38	11.73	58	40639	62022	90525728
Haematocrit decreased	12.24	11.73	44	40653	41788	90545962
Complication associated with device	12.21	11.73	27	40670	19422	90568328
Osteoarthritis	12.13	11.73	46	40651	195684	90392066
Ageusia	12.06	11.73	24	40673	16052	90571698
Blepharospasm	11.88	11.73	5	40692	55440	90532310
Cough	11.84	11.73	232	40465	368730	90219020
Anxiety	11.77	11.73	200	40497	309572	90278178

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	117.99	13.09	110	23650	638225	41959350
Product use in unapproved indication	82.91	13.09	5	23755	184451	42413124
Fatigue	65.18	13.09	440	23320	435201	42162374
Plasma cell myeloma	55.41	13.09	97	23663	47481	42550094
Fall	49.84	13.09	260	23500	234260	42363315
Diarrhoea	43.42	13.09	419	23341	460430	42137145
Full blood count decreased	41.20	13.09	54	23706	20506	42577069
Product dose omission issue	40.57	13.09	182	23578	154183	42443392
Asthenia	40.27	13.09	281	23479	280512	42317063
Laboratory test abnormal	39.46	13.09	56	23704	22922	42574653
Gait spastic	39.17	13.09	18	23742	1391	42596184
Needle fatigue	38.50	13.09	17	23743	1196	42596379
Completed suicide	36.95	13.09	5	23755	96460	42501115
Dizziness	36.64	13.09	251	23509	249003	42348572
Drug interaction	36.36	13.09	58	23702	266941	42330634
White blood cell count decreased	35.11	13.09	138	23622	110258	42487317
Relapsing-remitting multiple sclerosis	35.10	13.09	17	23743	1478	42596097
Multiple sclerosis relapse	34.22	13.09	41	23719	14223	42583352
Drug ineffective	30.64	13.09	216	23544	629981	41967594
Muscle spasticity	29.74	13.09	27	23733	6795	42590780
Toxicity to various agents	29.12	13.09	52	23708	229084	42368491
Memory impairment	28.95	13.09	77	23683	50145	42547430
Adverse drug reaction	28.63	13.09	64	23696	37370	42560205
COVID-19	27.78	13.09	15	23745	115933	42481642
Hypertonic bladder	27.68	13.09	17	23743	2364	42595211
Pneumonia	27.00	13.09	356	23404	421793	42175782
Monoparesis	24.31	13.09	17	23743	2943	42594632
Viral infection	23.81	13.09	44	23716	22439	42575136
Hypoaesthesia	23.24	13.09	90	23670	71373	42526202
Psoriasis	22.63	13.09	69	23691	48535	42549040
Balance disorder	22.52	13.09	68	23692	47577	42549998
General physical health deterioration	22.36	13.09	31	23729	151215	42446360
Intentional product use issue	20.86	13.09	7	23753	71826	42525749
Neuropathy peripheral	20.25	13.09	111	23649	101742	42495833
Sinusitis	20.05	13.09	65	23695	47227	42550348
Muscle spasms	20.04	13.09	98	23662	85946	42511629
Intentional product misuse	19.87	13.09	5	23755	61895	42535680
Central nervous system lesion	19.50	13.09	23	23737	7847	42589728
Rash	18.68	13.09	236	23524	276718	42320857
Influenza	18.37	13.09	76	23684	62099	42535476
Treatment failure	18.36	13.09	6	23754	62618	42534957
Interstitial lung disease	17.58	13.09	11	23749	78451	42519124
Multiple organ dysfunction syndrome	17.45	13.09	17	23743	97018	42500557
Unevaluable event	17.21	13.09	50	23710	34238	42563337
Overdose	17.19	13.09	20	23740	105244	42492331
Cardiac disorder	17.04	13.09	63	23697	48869	42548706
Peripheral swelling	17.03	13.09	97	23663	90173	42507402
Dehydration	16.92	13.09	136	23624	141631	42455944
Haemoglobin decreased	16.87	13.09	129	23631	132342	42465233
Febrile neutropenia	16.48	13.09	51	23709	185652	42411923
Constipation	16.39	13.09	150	23610	162141	42435434
Drug ineffective for unapproved indication	16.30	13.09	3	23757	46160	42551415
Influenza like illness	15.57	13.09	46	23714	31794	42565781
Cytokine release syndrome	15.49	13.09	3	23757	44524	42553051
Small intestinal obstruction	15.15	13.09	31	23729	17030	42580545
Hepatic function abnormal	15.01	13.09	5	23755	51562	42546013
Foetal exposure during pregnancy	14.84	13.09	4	23756	47307	42550268
Micturition urgency	14.81	13.09	25	23735	11873	42585702
Pollakiuria	14.51	13.09	36	23724	22469	42575106
Mental status changes	14.48	13.09	54	23706	42061	42555514
Coma	14.24	13.09	6	23754	53548	42544027
Platelet count decreased	13.94	13.09	128	23632	138453	42459122
Flatulence	13.92	13.09	38	23722	25114	42572461
Insomnia	13.87	13.09	113	23647	118140	42479435
Nocturia	13.20	13.09	24	23736	12088	42585487
Feeling abnormal	13.16	13.09	75	23685	69711	42527864

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	162.05	11.18	278	50719	1499907	109038395
Product use in unapproved indication	160.54	11.18	12	50985	447365	110090937
Fall	111.37	11.18	561	50436	602921	109935381
Product dose omission issue	108.78	11.18	361	50636	321421	110216881
Treatment failure	100.65	11.18	7	50990	277227	110261075
Completed suicide	88.33	11.18	6	50991	242375	110295927
Diarrhoea	87.77	11.18	855	50142	1138650	109399652
Device expulsion	82.92	11.18	86	50911	30805	110507497
Systemic lupus erythematosus	82.78	11.18	10	50987	254328	110283974
Drug intolerance	81.35	11.18	43	50954	406469	110131833
Dizziness	78.15	11.18	570	50427	697623	109840679
Drug ineffective	73.10	11.18	408	50589	1520132	109018170
Fatigue	72.06	11.18	866	50131	1215092	109323210
Plasma cell myeloma	71.06	11.18	114	50883	62822	110475480
Infusion related reaction	71	11.18	44	50953	381118	110157184
Product use issue	70.07	11.18	28	50969	311667	110226635
Drug abuse	68.96	11.18	3	50994	177408	110360894
Duodenal ulcer perforation	65.93	11.18	4	50993	177696	110360606
Helicobacter infection	64.83	11.18	5	50992	181872	110356430
Glossodynia	64.73	11.18	12	50985	221992	110316310
Intentional product use issue	63.14	11.18	18	50979	247888	110290414
Deep vein thrombosis	62.29	11.18	173	50824	139714	110398588
Asthenia	60.92	11.18	533	50464	688466	109849836
Maternal exposure during pregnancy	60.46	11.18	21	50976	254862	110283440
Pericarditis	59.45	11.18	14	50983	219100	110319202
Dehydration	58.00	11.18	269	50728	279242	110259060
Haemoglobin decreased	57.34	11.18	247	50750	248480	110289822
Toxicity to various agents	57.28	11.18	83	50914	480472	110057830
Folliculitis	56.03	11.18	6	50991	167647	110370655
Lower respiratory tract infection	56.01	11.18	21	50976	243085	110295217
General physical health deterioration	54.16	11.18	70	50927	425225	110113077
Therapy cessation	53.05	11.18	83	50914	44774	110493528
Drug hypersensitivity	52.59	11.18	80	50917	454010	110084292
Therapeutic product effect incomplete	50.45	11.18	20	50977	223785	110314517
Full blood count decreased	48.99	11.18	67	50930	32032	110506270
Hepatic enzyme increased	48.33	11.18	46	50951	320846	110217456
Unevaluable event	48.31	11.18	93	50904	59134	110479168
Feeling abnormal	47.58	11.18	187	50810	180524	110357778
COVID-19	47.43	11.18	27	50970	245033	110293269
Multiple sclerosis relapse	47.40	11.18	84	50913	50156	110488146
Device dislocation	46.63	11.18	65	50932	31639	110506663
Irritable bowel syndrome	45.52	11.18	10	50987	164205	110374097
Nausea	44.92	11.18	809	50188	1234881	109303421
Drug interaction	44.78	11.18	103	50894	500080	110038222
Needle fatigue	44.33	11.18	18	50979	1246	110537056
Gait spastic	44.05	11.18	19	50978	1530	110536772
C-reactive protein increased	43.64	11.18	23	50974	217896	110320406
Intentional overdose	43.62	11.18	5	50992	132496	110405806
Type 2 diabetes mellitus	43.07	11.18	14	50983	177218	110361084
Pneumonia	41.95	11.18	601	50396	876113	109662189
Relapsing-remitting multiple sclerosis	41.69	11.18	20	50977	2062	110536240
Wound	41.01	11.18	29	50968	234408	110303894
Fibromyalgia	40.66	11.18	14	50983	170895	110367407
Arthropathy	39.04	11.18	45	50952	287477	110250825
Liver injury	38.14	11.18	11	50986	150402	110387900
Muscle spasms	37.51	11.18	238	50759	277919	110260383
Intentional product misuse	37.03	11.18	8	50989	132896	110405406
Dyspnoea	36.82	11.18	715	50282	1106157	109432145
Joint swelling	36.63	11.18	95	50902	442750	110095552
Hypervolaemia	34.76	11.18	73	50924	49387	110488915
Fluid retention	33.77	11.18	108	50889	94199	110444103
Cardiac failure congestive	32.53	11.18	147	50850	150853	110387449
Ill-defined disorder	32.22	11.18	16	50981	156837	110381465
Mental status changes	31.78	11.18	92	50905	76030	110462272
Hospice care	30.41	11.18	33	50964	12440	110525862
Bursitis	30.29	11.18	11	50986	129907	110408395
Therapeutic product effect decreased	30.27	11.18	41	50956	244275	110294027
Hip fracture	29.65	11.18	56	50941	35095	110503207
Overdose	29.20	11.18	39	50958	233755	110304547
Flatulence	28.86	11.18	70	50927	52079	110486223
Influenza like illness	28.75	11.18	98	50899	88314	110449988
Dyspnoea exertional	27.63	11.18	108	50889	103952	110434350
Headache	27.61	11.18	565	50432	881812	109656490
Pollakiuria	27.38	11.18	62	50935	44133	110494169
Mobility decreased	27.29	11.18	42	50955	237380	110300922
Joint range of motion decreased	27.26	11.18	11	50986	121821	110416481
Back pain	27.19	11.18	276	50721	370720	110167582
Prescribed overdose	27.15	11.18	4	50993	87577	110450725
Haematocrit decreased	26.73	11.18	79	50918	66038	110472264
Blister	26.35	11.18	40	50957	227336	110310966
International normalised ratio increased	26.33	11.18	94	50903	86678	110451624
Hypercholesterolaemia	26.27	11.18	5	50992	90832	110447470
Asthma	26.24	11.18	47	50950	250244	110288058
White blood cell count decreased	25.96	11.18	188	50809	229202	110309100
Viral infection	25.93	11.18	68	50929	53071	110485231
Peripheral venous disease	25.71	11.18	4	50993	84113	110454189
Injection site pain	25.70	11.18	155	50842	177767	110360535
Urinary tract infection	25.49	11.18	246	50751	326036	110212266
Pelvic pain	25.43	11.18	34	50963	15908	110522394
Blood potassium decreased	25.14	11.18	68	50929	54046	110484256
Rheumatoid arthritis	24.97	11.18	64	50933	299549	110238753
Constipation	24.71	11.18	263	50734	357523	110180779
Cellulitis	24.44	11.18	119	50878	125897	110412405
Injection site erythema	24.41	11.18	97	50900	94079	110444223
Small intestinal obstruction	24.35	11.18	49	50948	32164	110506138
Pulmonary hypertension	24.27	11.18	68	50929	55152	110483150
Epilepsy	24.19	11.18	8	50989	100201	110438101
Obesity	24.14	11.18	11	50986	113340	110424962
Grip strength decreased	24.09	11.18	4	50993	80170	110458132
Pulmonary arterial hypertension	23.97	11.18	49	50948	32519	110505783
Pulmonary embolism	23.25	11.18	174	50823	214300	110324002
Monoparesis	22.78	11.18	18	50979	4535	110533767
Balance disorder	22.56	11.18	110	50887	116450	110421852
Hypertonic bladder	22.41	11.18	19	50978	5283	110533019
Injection site haemorrhage	22.34	11.18	48	50949	32980	110505322
Gastrointestinal disorder	22.29	11.18	49	50948	241903	110296399
Cytokine release syndrome	22.29	11.18	3	50994	70303	110467999
Tremor	21.89	11.18	164	50833	202068	110336234
Micturition urgency	21.81	11.18	35	50962	19285	110519017
Neuropathy peripheral	21.49	11.18	149	50848	179128	110359174
Pleural effusion	21.48	11.18	148	50849	177561	110360741
Nasal congestion	21.40	11.18	96	50901	98186	110440116
Platelet count decreased	21.18	11.18	180	50817	230263	110308039
Therapeutic response decreased	21.13	11.18	9	50988	96490	110441812
Oedema peripheral	21.04	11.18	238	50759	328422	110209880
Discomfort	21.03	11.18	42	50955	214665	110323637
Complication associated with device	20.81	11.18	35	50962	20038	110518264
Hypoxia	20.76	11.18	116	50881	129399	110408903
Impaired healing	20.56	11.18	37	50960	196680	110341622
Suicide attempt	20.56	11.18	11	50986	103383	110434919
Dysgeusia	20.54	11.18	75	50922	69910	110468392
Flushing	20.38	11.18	99	50898	104637	110433665
Chills	20.31	11.18	154	50843	190426	110347876
Wheezing	20.14	11.18	56	50941	255174	110283128
Gastrointestinal haemorrhage	20.09	11.18	138	50859	165380	110372922
Eye swelling	20.07	11.18	46	50951	33002	110505300
Exposure during pregnancy	19.83	11.18	29	50968	167395	110370907
Live birth	19.73	11.18	4	50993	69480	110468822
Product complaint	19.59	11.18	28	50969	13944	110524358
Cardiac disorder	19.31	11.18	78	50919	76202	110462100
Bronchitis	19.11	11.18	131	50866	156901	110381401
Illness	19.08	11.18	7	50990	82164	110456138
Drug ineffective for unapproved indication	18.95	11.18	12	50985	102826	110435476
Vaginal haemorrhage	18.78	11.18	38	50959	25036	110513266
Inflammation	18.75	11.18	38	50959	193200	110345102
Condition aggravated	18.70	11.18	233	50764	734603	109803699
Sleep disorder	18.49	11.18	40	50957	198604	110339698
Atrial fibrillation	18.35	11.18	174	50823	229468	110308834
Anxiety	18.23	11.18	241	50756	344837	110193465
Autoimmune disorder	18.12	11.18	4	50993	65479	110472823
Abdominal pain	17.86	11.18	334	50663	512655	110025647
Lung disorder	17.82	11.18	35	50962	180012	110358290
Weight decreased	17.44	11.18	308	50689	467749	110070553
Hypersensitivity	17.36	11.18	112	50885	403886	110134416
Transfusion	17.21	11.18	37	50960	25435	110512867
Drug-induced liver injury	17.16	11.18	18	50979	120049	110418253
Hepatic function abnormal	17.03	11.18	10	50987	89285	110449017
Bone pain	16.80	11.18	67	50930	65066	110473236
Nocturia	16.79	11.18	29	50968	16961	110521341
Wound infection	16.77	11.18	12	50985	96453	110441849
Chest pain	16.73	11.18	255	50742	376120	110162182
Laryngeal pain	16.69	11.18	17	50980	5958	110532344
Liver disorder	16.50	11.18	25	50972	142218	110396084
Hypertension	16.48	11.18	153	50844	509931	110028371
Red blood cell count decreased	16.36	11.18	67	50930	65856	110472446
Stomatitis	16.07	11.18	67	50930	270175	110268127
Atelectasis	15.93	11.18	45	50952	36667	110501635
Disease progression	15.74	11.18	177	50820	243857	110294445
Depression	15.68	11.18	219	50778	317116	110221186
Thrombosis	15.26	11.18	94	50903	108568	110429734
Infection	15.26	11.18	101	50896	362099	110176203
Ataxia	15.17	11.18	39	50958	30069	110508233
Pain in jaw	15.15	11.18	55	50942	51122	110487180
Eosinophilia	15.13	11.18	4	50993	57932	110480370
Myalgia	15.12	11.18	163	50834	222218	110316084
Hypophagia	15.11	11.18	56	50941	52570	110485732
Heavy menstrual bleeding	14.97	11.18	27	50970	16338	110521964
Erectile dysfunction	14.96	11.18	29	50968	18527	110519775
Agranulocytosis	14.79	11.18	5	50992	61755	110476547
Depressed level of consciousness	14.77	11.18	18	50979	112260	110426042
Gallbladder disorder	14.73	11.18	31	50966	20998	110517304
Central nervous system lesion	14.66	11.18	26	50971	15527	110522775
Multiple organ dysfunction syndrome	14.57	11.18	30	50967	151680	110386622
Infective pulmonary exacerbation of cystic fibrosis	14.32	11.18	25	50972	14746	110523556
Cholestasis	14.15	11.18	6	50991	64512	110473790
Application site erythema	13.95	11.18	15	50982	5595	110532707
Blepharospasm	13.92	11.18	4	50993	54847	110483455
Interstitial lung disease	13.86	11.18	27	50970	139307	110398995
Cytomegalovirus infection	13.76	11.18	4	50993	54440	110483862
Gait disturbance	13.74	11.18	192	50805	278016	110260286
Blood glucose decreased	13.64	11.18	37	50960	29451	110508851
Vision blurred	13.60	11.18	104	50893	128918	110409384
Blood cholesterol increased	13.52	11.18	42	50955	184743	110353559
Nail disorder	13.34	11.18	5	50992	57930	110480372
Drug reaction with eosinophilia and systemic symptoms	13.27	11.18	11	50986	82084	110456218
Rotator cuff syndrome	13.24	11.18	26	50971	16768	110521534
Sleep disorder due to a general medical condition	12.86	11.18	4	50993	52108	110486194
Transient ischaemic attack	12.82	11.18	61	50936	63921	110474381
Drug resistance	12.76	11.18	5	50992	56369	110481933
Pulmonary fibrosis	12.76	11.18	17	50980	102025	110436277
Aspartate aminotransferase increased	12.68	11.18	121	50876	159815	110378487
Psoriasis	12.67	11.18	109	50888	139884	110398418
Lethargy	12.55	11.18	80	50917	93496	110444806
Hot flush	12.54	11.18	62	50935	65974	110472328
Cardiac pacemaker insertion	12.53	11.18	15	50982	6286	110532016
Bone erosion	12.50	11.18	3	50994	46368	110491934
Influenza	12.46	11.18	126	50871	168975	110369327
Application site pain	12.46	11.18	14	50983	5485	110532817
Swelling face	12.43	11.18	79	50918	92242	110446060
Alopecia	12.39	11.18	108	50889	364645	110173657
Osteoarthritis	12.33	11.18	43	50954	182580	110355722
Application site discolouration	12.19	11.18	7	50990	1042	110537260
Hospitalisation	11.89	11.18	109	50888	142384	110395918
Abdominal adhesions	11.85	11.18	12	50985	4178	110534124
Muscle spasticity	11.84	11.18	40	50957	35875	110502427
Granulocytopenia	11.66	11.18	21	50976	12694	110525608
Dialysis	11.57	11.18	27	50970	19592	110518710
Rib fracture	11.48	11.18	38	50959	33732	110504570
Rash pruritic	11.45	11.18	81	50916	97988	110440314
Intestinal dilatation	11.41	11.18	11	50986	3609	110534693
Blood glucose increased	11.39	11.18	102	50895	132394	110405908

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000960	Hypolipidemic Agents
MeSH PA	D000963	Antimetabolites
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D008082	Lipotropic Agents
MeSH PA	D018697	Nootropic Agents
MeSH PA	D057847	Lipid Regulating Agents
CHEBI has role	CHEBI:25512	neurotransmitter
CHEBI has role	CHEBI:33284	nutrient
CHEBI has role	CHEBI:50904	allergen
CHEBI has role	CHEBI:75771	mouse metabolite
CHEBI has role	CHEBI:75772	<em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role	CHEBI:76924	plant metabolite
CHEBI has role	CHEBI:76971	<em>Escherichia coli</em> metabolite
CHEBI has role	CHEBI:77746	human metabolite
CHEBI has role	CHEBI:83056	<em>Daphnia magna</em> metabolite
CHEBI has role	CHEBI:82655	animal growth promotant

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Insomnia	indication	193462001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Acetylcholine receptor subunit delta	Ion channel		ACHD_TORCA		Ki	4.38		CHEMBL
High affinity choline transporter 1	Transporter		SC5A7_MOUSE		IC50	5.80		CHEMBL
Neuronal acetylcholine receptor; alpha2/beta2	Ion channel		ACHA2_RAT ACHB2_RAT		Ki	4.74		CHEMBL
Neuronal acetylcholine receptor; alpha3/beta2	Ion channel		ACHA3_RAT ACHB2_RAT		Ki	4.43		CHEMBL
Neuronal acetylcholine receptor; alpha3/beta4	Ion channel		ACHA3_RAT ACHB4_RAT		Ki	4.32		CHEMBL
Neuronal acetylcholine receptor; alpha4/beta2	Ion channel		ACHA4_RAT ACHB2_RAT		Ki	4.43		CHEMBL
Neuronal acetylcholine receptor; alpha4/beta4	Ion channel		ACHA4_RAT ACHB4_RAT		Ki	4.47		CHEMBL
Creatine transporter	Transporter		SC6A8_RAT		Ki	4.38		CHEMBL

External reference:

ID	Source
N91BDP6H0X	UNII
4020078	VUID
N0000178902	NUI
D07690	KEGG_DRUG
67-48-1	SECONDARY_CAS_RN
4017687	VANDF
4017699	VANDF
4020077	VANDF
4020078	VANDF
C0008405	UMLSCUI
CHEBI:15354	CHEBI
CHT	PDB_CHEM_ID
CHEMBL920	ChEMBL_ID
305	PUBCHEM_CID
DB00122	DRUGBANK_ID
CHEMBL282468	ChEMBL_ID
CHEMBL2105935	ChEMBL_ID
D002794	MESH_DESCRIPTOR_UI
4551	IUPHAR_LIGAND_ID
87-67-2	SECONDARY_CAS_RN
1425426	RXNORM
43412	MMSL
4436	MMSL
4437	MMSL
4875	MMSL
4880	MMSL
NOCODE	MMSL
d03064	MMSL
d03159	MMSL
002058	NDDF
002059	NDDF
005105	NDDF
111156002	SNOMEDCT_US
387030006	SNOMEDCT_US
427976002	SNOMEDCT_US
65123005	SNOMEDCT_US
442	INN_ID
N91BDP6H0X	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
NESTABSPrenatal Multi-vitamin/Mineral Supplement	HUMAN PRESCRIPTION DRUG LABEL	15	50967-219	TABLET, FILM COATED	55 mg	ORAL	unapproved drug other	8 sections
Prenatol-M	HUMAN PRESCRIPTION DRUG LABEL	20	59088-009	TABLET	55 mg	ORAL	unapproved drug other	13 sections
Vitalux	HUMAN PRESCRIPTION DRUG LABEL	20	59088-139	TABLET	55 mg	ORAL	unapproved drug other	13 sections
Prenatrix	HUMAN PRESCRIPTION DRUG LABEL	20	59088-166	TABLET	55 mg	ORAL	unapproved drug other	13 sections
Prenatryl	HUMAN PRESCRIPTION DRUG LABEL	20	59088-169	TABLET	55 mg	ORAL	unapproved drug other	13 sections
Prometa	HUMAN PRESCRIPTION DRUG LABEL	20	59088-172	TABLET	55 mg	ORAL	unapproved drug other	13 sections
Pretrate	HUMAN PRESCRIPTION DRUG LABEL	20	59088-178	TABLET	55 mg	ORAL	unapproved drug other	13 sections
Livita Adults	HUMAN PRESCRIPTION DRUG LABEL	17	59088-659	LIQUID	200 mg	ORAL	unapproved drug other	10 sections
Livita Children	HUMAN PRESCRIPTION DRUG LABEL	17	59088-660	LIQUID	66.67 mg	ORAL	unapproved drug other	10 sections
Lipovite	HUMAN PRESCRIPTION DRUG LABEL	13	70104-128	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections