choline Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3097 62-49-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • choline chloride
  • choline
  • vitamin J
  • bilineurine
  • choline ion
  • choline bitartrate
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
  • Molecular weight: 104.17
  • Formula: C5H14NO
  • CLOGP: -4.36
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -1.59
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000963 Antimetabolites
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents
MeSH PA D008082 Lipotropic Agents
MeSH PA D018697 Nootropic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholine receptor subunit delta Ion channel Ki 4.38 CHEMBL
Neuronal acetylcholine receptor; alpha4/beta4 Ion channel Ki 4.47 CHEMBL
Neuronal acetylcholine receptor; alpha4/beta2 Ion channel Ki 4.43 CHEMBL
Creatine transporter Unclassified Ki 4.38 CHEMBL
Neuronal acetylcholine receptor; alpha3/beta2 Ion channel Ki 4.43 CHEMBL
Neuronal acetylcholine receptor; alpha3/beta4 Ion channel Ki 4.32 CHEMBL
Neuronal acetylcholine receptor; alpha2/beta2 Ion channel Ki 4.74 CHEMBL
High affinity choline transporter 1 Unclassified IC50 5.80 CHEMBL

External reference:

IDSource
D002794 MESH_DESCRIPTOR_UI
4020078 VUID
N0000178902 NUI
C0008409 UMLSCUI
D07690 KEGG_DRUG
45I14D8O27 UNII
442 INN_ID
67-48-1 SECONDARY_CAS_RN
111156002 SNOMEDCT_US
4017699 VANDF
002058 NDDF
4875 MMSL
2449 RXNORM
65123005 SNOMEDCT_US
4436 MMSL
d03159 MMSL
305 PUBCHEM_CID
CHEBI:15354 CHEBI
CHEMBL282468 ChEMBL_ID
CHEMBL920 ChEMBL_ID
DB00122 DRUGBANK_ID
CHT PDB_CHEM_ID
4551 IUPHAR_LIGAND_ID
CHEMBL2105935 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Duet DHA Balanced HUMAN PRESCRIPTION DRUG LABEL 14 44118-750 KIT 55 mg None unapproved drug other 10 sections
Pre-Tabs DHA HUMAN PRESCRIPTION DRUG LABEL 16 48948-406 KIT 55 mg None unapproved drug other 10 sections
NESTABS HUMAN PRESCRIPTION DRUG LABEL 13 50967-219 TABLET, FILM COATED 55 mg ORAL unapproved drug other 7 sections
NESTABS DHA HUMAN PRESCRIPTION DRUG LABEL 15 50967-317 KIT 55 mg None unapproved drug other 9 sections
Prenatal, DHA HUMAN PRESCRIPTION DRUG LABEL 14 59088-096 KIT 55 mg None Unapproved drug other 10 sections
Senophylline HUMAN PRESCRIPTION DRUG LABEL 2 68405-002 KIT 250 mg None unapproved drug other 22 sections
Trazamine HUMAN PRESCRIPTION DRUG LABEL 2 68405-003 KIT 250 mg None unapproved drug other 24 sections
Gabitidine HUMAN PRESCRIPTION DRUG LABEL 2 68405-004 KIT 125 mg None unapproved drug other 21 sections
Sentralopram AM-10 HUMAN PRESCRIPTION DRUG LABEL 2 68405-012 KIT 250 mg None unapproved drug other 27 sections
Strazepam HUMAN PRESCRIPTION DRUG LABEL 2 68405-013 KIT 250 mg None unapproved drug other 26 sections
Gaboxetine HUMAN PRESCRIPTION DRUG LABEL 2 68405-014 KIT 125 mg None unapproved drug other 28 sections
Sentraflox AM-10 HUMAN PRESCRIPTION DRUG LABEL 2 68405-022 KIT 250 mg None unapproved drug other 20 sections
Sentrazolpidem PM-5 HUMAN PRESCRIPTION DRUG LABEL 2 68405-023 KIT 250 mg ORAL unapproved drug other 28 sections
Gabazolamine HUMAN PRESCRIPTION DRUG LABEL 2 68405-024 KIT 125 mg None unapproved drug other 26 sections
Sentrazolam AM HUMAN PRESCRIPTION DRUG LABEL 2 68405-032 KIT 250 mg None unapproved drug other 27 sections
Sentradine HUMAN PRESCRIPTION DRUG LABEL 2 68405-033 KIT 250 mg None unapproved drug other 19 sections
Gabazolamine-0.5 HUMAN PRESCRIPTION DRUG LABEL 2 68405-034 KIT 125 mg None unapproved drug other 27 sections
Sentroxatine HUMAN PRESCRIPTION DRUG LABEL 2 68405-043 KIT 250 mg None unapproved drug other 29 sections
Gabazolpidem-5 HUMAN PRESCRIPTION DRUG LABEL 2 68405-044 KIT 125 mg None unapproved drug other 28 sections
Sentravil PM-25 HUMAN PRESCRIPTION DRUG LABEL 2 68405-053 KIT 250 mg None unapproved drug other 22 sections
Gabavale-5 HUMAN PRESCRIPTION DRUG LABEL 2 68405-054 KIT 125 mg None unapproved drug other 18 sections
Lipovite HUMAN PRESCRIPTION DRUG LABEL 11 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Viatrexx-Liver HUMAN PRESCRIPTION DRUG LABEL 9 73069-300 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Viatrexx-Neuro 3 HUMAN PRESCRIPTION DRUG LABEL 15 73069-373 INJECTION 201 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Viatrexx-Relief Plus HUMAN PRESCRIPTION DRUG LABEL 2 73069-450 INJECTION 201 [kp_C] INTRAVENOUS unapproved drug other 11 sections