carbaryl Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3066 63-25-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carbaryl
  • menaphtam
  • 1-Naphthyl methylcarbamate
  • arilat
  • arilate
  • caprolin
  • carbaril
  • carbatox
  • carbavur
  • carbomate
A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.
  • Molecular weight: 201.23
  • Formula: C12H11NO2
  • CLOGP: 2.38
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 38.33
  • ALOGS: -3.34
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:22153 acaricides
CHEBI has role CHEBI:33286 agrichemical
CHEBI has role CHEBI:35219 plant growth inhibitors
CHEBI has role CHEBI:37733 bche inhibitor
CHEBI has role CHEBI:38461 carbamate insecticides
CHEBI has role CHEBI:38462 acetylcholinesterase inhibitors
MeSH PA D018678 Cholinergic Agents
MeSH PA D002800 Cholinesterase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007306 Insecticides
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010575 Pesticides

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.74 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme IC50 7.32 CHEMBL
Acetylcholinesterase Enzyme IC50 5.21 CHEMBL
Acetylcholinesterase Enzyme IC50 5.51 CHEMBL
Acetylcholinesterase Enzyme IC50 6.70 CHEMBL
Ace-orthologous acetylcholinesterase; Acetylcholinesterase Unclassified IC50 7.54 CHEMBL

External reference:

IDSource
N0000167377 NUI
D07613 KEGG_DRUG
C0036860 UMLSCUI
CHEBI:3390 CHEBI
6129 PUBCHEM_CID
CHEMBL46917 ChEMBL_ID
DB15930 DRUGBANK_ID
D012721 MESH_DESCRIPTOR_UI
2858 INN_ID
R890C8J3N1 UNII
9724 RXNORM
003720 NDDF
333035001 SNOMEDCT_US
9021002 SNOMEDCT_US

Pharmaceutical products:

None