carbaryl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3066 | 63-25-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:22153 | acaricides |
| CHEBI has role | CHEBI:33286 | agricultural chemicals |
| CHEBI has role | CHEBI:35219 | plant growth inhibitors |
| CHEBI has role | CHEBI:37733 | EC 3.1.1.8 inhibitor |
| CHEBI has role | CHEBI:38461 | carbamate insecticides |
| CHEBI has role | CHEBI:38462 | acetylcholinesterase inhibitors |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D010575 | Pesticides |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.74 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | Enzyme | IC50 | 5.51 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 5.21 | CHEMBL | |||||
| Ace-orthologous acetylcholinesterase; Acetylcholinesterase | Enzyme | IC50 | 7.54 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 6.70 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 7.32 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167377 | NUI |
| D07613 | KEGG_DRUG |
| C0036860 | UMLSCUI |
| CHEBI:3390 | CHEBI |
| CHEMBL46917 | ChEMBL_ID |
| DB15930 | DRUGBANK_ID |
| D012721 | MESH_DESCRIPTOR_UI |
| 6129 | PUBCHEM_CID |
| 9724 | RXNORM |
| 003720 | NDDF |
| 333035001 | SNOMEDCT_US |
| 9021002 | SNOMEDCT_US |
| 2858 | INN_ID |
| R890C8J3N1 | UNII |
Pharmaceutical products:
None