canfosfamide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives 3062 158382-37-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • canfosfamide hydrochloride
  • TLK286
  • TER286
  • canfosfamide
  • canfosfamide HCl
a glutathione-based glutathione S-transferase-activated cytotoxin; TLK-286 is the ((R)-(-))-isomer
  • Molecular weight: 787.46
  • Formula: C26H40Cl4N5O10PS
  • CLOGP: -0.20
  • LIPINSKI: 2
  • HAC: 15
  • HDO: 5
  • TPSA: 225.74
  • ALOGS: -4.31
  • ROTB: 25

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.46 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 28.50 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.28 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.97 acidic
pKa2 2.95 acidic
pKa3 12.25 acidic
pKa4 9.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03351 KEGG_DRUG
439943-59-6 SECONDARY_CAS_RN
C2827096 UMLSCUI
CHEBI:135883 CHEBI
CHEMBL2111086 ChEMBL_ID
CHEMBL2107319 ChEMBL_ID
DB04972 DRUGBANK_ID
8455 INN_ID
C107479 MESH_SUPPLEMENTAL_RECORD_UI
5312109 PUBCHEM_CID
1RS284BFUI UNII

Pharmaceutical products:

None