somatostatin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2997	38916-34-6

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: somatostatin aminopan growth hormone release-inhibiting factor somatotropin release-inhibiting hormone SRIF-14

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal. Molecular weight: 1637.90 Formula: C76H104N18O19S2 CLOGP: -1.46 LIPINSKI: 3 HAC: 37 HDO: 22 TPSA: 613.23 ALOGS: -4.90 ROTB: 26

Drug dosage:

Dose	Unit	Route
6	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

Source	Code	Description
ATC	H01CB01	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES HYPOTHALAMIC HORMONES Somatostatin and analogues
MeSH PA	D006728	Hormones

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.02	acidic
pKa2	12.17	acidic
pKa3	12.57	acidic
pKa4	12.85	acidic
pKa5	13.02	acidic
pKa6	13.2	acidic
pKa7	13.52	acidic
pKa8	13.6	acidic
pKa9	13.77	acidic
pKa10	13.88	acidic
pKa11	11.11	Basic
pKa12	10.51	Basic
pKa13	8.46	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Somatostatin receptor type 2	GPCR	P30874	SSR2_HUMAN	AGONIST	Ki	10.46		CHEMBL	IUPHAR
Somatostatin receptor type 1	GPCR	P30872	SSR1_HUMAN	AGONIST	Ki	9.54		CHEMBL	IUPHAR
Somatostatin receptor type 5	GPCR	P35346	SSR5_HUMAN	AGONIST	Ki	9.85		CHEMBL	IUPHAR
Somatostatin receptor type 3	GPCR	P32745	SSR3_HUMAN	AGONIST	Ki	10		CHEMBL	IUPHAR
Somatostatin receptor type 4	GPCR	P31391	SSR4_HUMAN	AGONIST	Ki	9.23		CHEMBL	IUPHAR
Mu-type opioid receptor	GPCR		OPRM_RAT		IC50	8.22		CHEMBL
Somatostatin receptor	GPCR		SSR1_RAT SSR2_RAT SSR3_RAT SSR4_RAT SSR5_RAT		IC50	9.70		CHEMBL
Somatostatin receptor	GPCR		SSR1_MOUSE SSR2_MOUSE SSR3_MOUSE SSR4_MOUSE SSR5_MOUSE		IC50	5.89		CHEMBL
Somatostatin receptor type 5	GPCR		SSR5_RAT		IC50	9.07		CHEMBL
Somatostatin receptor type 2	GPCR		SSR2_MOUSE		IC50	9.55		CHEMBL
Delta-type opioid receptor	GPCR		OPRD_RAT		IC50	5.70		CHEMBL
Somatostatin receptor type 3	GPCR		SSR3_MOUSE		IC50	10.10		CHEMBL

External reference:

ID	Source
N0000007997	NUI
C0037659	UMLSCUI
D07431	KEGG_DRUG
6E20216Q0L	UNII
4311	INN_ID
57819002	SNOMEDCT_US
49722008	SNOMEDCT_US
9939	RXNORM
005072	NDDF
DB09099	DRUGBANK_ID
CHEBI:64628	CHEBI
D013004	MESH_DESCRIPTOR_UI
CHEMBL1823872	ChEMBL_ID
16129706	PUBCHEM_CID
2019	IUPHAR_LIGAND_ID

Pharmaceutical products:

None