Target Card Uniprot Example: P23975

somatostatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2997	38916-34-6

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: somatostatin aminopan growth hormone release-inhibiting factor somatotropin release-inhibiting hormone SRIF-14

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal. Molecular weight: 1637.90 Formula: C76H104N18O19S2 CLOGP: -1.45 LIPINSKI: 3 HAC: 37 HDO: 22 TPSA: 613.23 ALOGS: -4.90 ROTB: 26

Drug dosage:

Dose	Unit	Route
6	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Administration site abscess	48.57	43.34	5	242	18	50604859
Administration site induration	47.96	43.34	5	242	21	50604856
Administration site discharge	47.59	43.34	5	242	23	50604854
Administration site odour	45.68	43.34	5	242	36	50604841
Injection site cyst	43.86	43.34	5	242	54	50604823

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastric varices	53.48	32.86	8	444	522	64497758
Administration site induration	46.74	32.86	5	447	18	64498262
Administration site abscess	46.74	32.86	5	447	18	64498262
Administration site discharge	45.25	32.86	5	447	26	64498254
Administration site odour	45.09	32.86	5	447	27	64498253
Administration site haemorrhage	42.96	32.86	5	447	44	64498236
Injection site cyst	40.97	32.86	5	447	68	64498212
Buttock injury	37.67	32.86	5	447	136	64498144
Portal hypertension	33.81	32.86	8	444	6211	64492069

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	H01CB01	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES HYPOTHALAMIC HORMONES Somatostatin and analogues
MeSH PA	D006728	Hormones

Drug Use (View source of the data)

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.02	acidic
pKa2	12.17	acidic
pKa3	12.57	acidic
pKa4	12.85	acidic
pKa5	13.02	acidic
pKa6	13.2	acidic
pKa7	13.52	acidic
pKa8	13.6	acidic
pKa9	13.77	acidic
pKa10	13.88	acidic
pKa11	11.11	Basic
pKa12	10.51	Basic
pKa13	8.46	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Somatostatin receptor type 2	GPCR	P30874	SSR2_HUMAN	AGONIST	Ki	10.46		CHEMBL	IUPHAR
Somatostatin receptor type 3	GPCR	P32745	SSR3_HUMAN	AGONIST	Ki	10		CHEMBL	IUPHAR
Somatostatin receptor type 5	GPCR	P35346	SSR5_HUMAN	AGONIST	Ki	9.85		CHEMBL	IUPHAR
Somatostatin receptor type 4	GPCR	P31391	SSR4_HUMAN	AGONIST	Ki	9.23		CHEMBL	IUPHAR
Somatostatin receptor type 1	GPCR	P30872	SSR1_HUMAN	AGONIST	Ki	9.54		CHEMBL	IUPHAR
Somatostatin receptor	GPCR		SSR5_MOUSE SSR1_MOUSE SSR2_MOUSE SSR3_MOUSE SSR4_MOUSE		IC50	5.89		CHEMBL
Mu-type opioid receptor	GPCR		OPRM_RAT		IC50	8.22		CHEMBL
Somatostatin receptor	GPCR		SSR1_RAT SSR2_RAT SSR3_RAT SSR4_RAT SSR5_RAT		IC50	9.70		CHEMBL
Delta-type opioid receptor	GPCR		OPRD_RAT		IC50	5.70		CHEMBL
Somatostatin receptor type 2	GPCR		SSR2_MOUSE		IC50	9.55		CHEMBL
Somatostatin receptor type 3	GPCR		SSR3_MOUSE		IC50	10.10		CHEMBL
Somatostatin receptor type 5	GPCR		SSR5_RAT		IC50	9.07		CHEMBL

External reference:

ID	Source
N0000007997	NUI
D07431	KEGG_DRUG
C0037659	UMLSCUI
CHEBI:64628	CHEBI
CHEMBL1823872	ChEMBL_ID
D013004	MESH_DESCRIPTOR_UI
DB09099	DRUGBANK_ID
2019	IUPHAR_LIGAND_ID
4311	INN_ID
6E20216Q0L	UNII
16129706	PUBCHEM_CID
9939	RXNORM
005072	NDDF
49722008	SNOMEDCT_US
57819002	SNOMEDCT_US

Pharmaceutical products:

None