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belotecan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antineoplastics, topoisomerase I inhibitors | 296 | 256411-32-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.486 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 19.320 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 1.560 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 1.514 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 55.620 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 63.370 | % | High | 1 |
| herg | hERG pIC50 | 4.704 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.766 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 17.179 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 47.700 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CLK4,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GAK,GRK2,GSK3B,IKBKB,INSR,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PIM3,PLK1,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 | 70 | |||
| kinase-selectivity-class | AXL,CAMK2D,CLK4,EIF2AK3,MAP2K6,MAP3K7,PDK1,STK33,TEK,ZAP70 | 10 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 8.892 | Moderate | 0.75 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 9.594 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 8.851 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 46.950 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 10.814 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 73.410 | % | High | 1 |
| rat-kpuu-brain | Rat brain Kpuu | 0.018 | % | Moderate | 0.75 |
| rh-clint | Rat hepatocyte intrinsic clearance | 5.433 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 80.510 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 50.350 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 393.550 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 10, 2003 | Korean Food and Drug Administration (KFDA) | Chong Kun Dang |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01CE04 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Topoisomerase 1 (TOP1) inhibitors |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D059003 | Topoisomerase Inhibitors |
| MeSH PA | D059004 | Topoisomerase I Inhibitors |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
Related Drugs by ATC class:
L01CE Topoisomerase 1 (TOP1) inhibitors 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
| Malignant tumor of ovary | indication | 363443007 | DOID:2394 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.72 | acidic |
| pKa2 | 10.12 | Basic |
| pKa3 | 2.85 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| DNA topoisomerase 1 | Enzyme | INHIBITOR | IC50 | 6.56 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| C0762737 | UMLSCUI |
| CHEBI:135702 | CHEBI |
| D03225 | KEGG_DRUG |
| CHEMBL2111084 | ChEMBL_ID |
| DB12459 | DRUGBANK_ID |
| C116963 | MESH_SUPPLEMENTAL_RECORD_UI |
| 8483 | INN_ID |
| 27Z82M2G1N | UNII |
| 6456014 | PUBCHEM_CID |
| CHEMBL2107315 | ChEMBL_ID |
| 213819-48-8 | SECONDARY_CAS_RN |
Pharmaceutical products:
None