vesnarinone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
cardiac stimulants, amrinone derivatives 2817 81840-15-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vesnarinone
  • pieranometazine
  • OPC-8212
  • Molecular weight: 395.46
  • Formula: C22H25N3O4
  • CLOGP: 1.82
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 71.11
  • ALOGS: -3.61
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000998 Antiviral Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D020011 Protective Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.79 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
cGMP-inhibited 3',5'-cyclic phosphodiesterase B Enzyme IC50 4.88 CHEMBL
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Enzyme IC50 4.97 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.96 CHEMBL
Phosphodiesterase 3 Enzyme IC50 5.21 CHEMBL
Transitional endoplasmic reticulum ATPase Enzyme SCIENTIFIC LITERATURE

External reference:

IDSource
D01690 KEGG_DRUG
4025279 VANDF
C0069567 UMLSCUI
CHEBI:31237 CHEBI
CHEMBL17423 ChEMBL_ID
C041667 MESH_SUPPLEMENTAL_RECORD_UI
6108 INN_ID
DB12082 DRUGBANK_ID
5COW40EV8M UNII
5663 PUBCHEM_CID

Pharmaceutical products:

None