unoprostone isopropyl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
prostaglandins 2794 120373-24-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • unoprostone isopropyl ester
  • isopropyl unoprostone
  • rescula
  • unoprostone isopropyl
a safe and effective ocular hypotensive drug
  • Molecular weight: 424.62
  • Formula: C25H44O5
  • CLOGP: 4.54
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 83.83
  • ALOGS: -4.80
  • ROTB: 17
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PLK1,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 51
kinase-selectivity-class AXL,EPHB4,GRK2,MAP2K6,TEK 5
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Aug. 3, 2000 FDA SUCAMPO PHARMA LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:66981 ophthalmology drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282
Open-angle glaucoma indication 84494001 DOID:1067




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021244 VUID
N0000179516 NUI
D01452 KEGG_DRUG
4021244 VANDF
CHEMBL1200661 ChEMBL_ID
C072630 MESH_SUPPLEMENTAL_RECORD_UI
8282 IUPHAR_LIGAND_ID
5M161S5O5P UNII
135313 RXNORM
15695 MMSL
37952 MMSL
008857 NDDF
410844009 SNOMEDCT_US
410845005 SNOMEDCT_US
C0527038 UMLSCUI
CHEBI:31731 CHEBI
5282175 PUBCHEM_CID
120373-36-6 SECONDARY_CAS_RN
5M161S5O5P INXIGHT DRUGS

Pharmaceutical products:

None