triparanol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2761 78-41-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triparanol
  • clotrox
  • metasclene
  • metasqualene
  • trianel
  • triparin
  • tropalin
Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts.
  • Molecular weight: 438.01
  • Formula: C27H32ClNO2
  • CLOGP: 6.71
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 1
  • TPSA: 32.70
  • ALOGS: -6.18
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000963 Antimetabolites
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 8.10 CHEMBL
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 7.96 CHEMBL
C-8 sterol isomerase Enzyme Ki 8.70 CHEMBL

External reference:

IDSource
63S8C3RXGS UNII
1010 INN_ID
CHEMBL187709 ChEMBL_ID
CHEBI:135714 CHEBI
D014308 MESH_DESCRIPTOR_UI
6536 PUBCHEM_CID

Pharmaceutical products:

None