trilostane Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2746 13647-35-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trilostane
  • modrastane
  • modrefen
  • modrenal
  • desopan
inhibits conversion of pregnenolone to progesterone; adrenal blocking agent used in treatment of Cushing's syndrome
  • Molecular weight: 329.44
  • Formula: C20H27NO3
  • CLOGP: 2.33
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 76.78
  • ALOGS: -3.75
  • ROTB: 0

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.36 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA BIOENVISION

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC H02CA01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
ANTIADRENAL PREPARATIONS
Anticorticosteroids
MeSH PA D000019 Abortifacient Agents
MeSH PA D000021 Abortifacient Agents, Steroidal
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:50691 abortifacient agent
CHEBI has role CHEBI:50788 3beta-hsd

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypercortisolism indication 47270006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.75 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 Enzyme INHIBITOR DRUGBANK CHEMBL

External reference:

IDSource
4020465 VUID
N0000148218 NUI
D01180 KEGG_DRUG
4020465 VANDF
C1519649 UMLSCUI
CHEBI:32260 CHEBI
CHEMBL1200907 ChEMBL_ID
C009954 MESH_SUPPLEMENTAL_RECORD_UI
535161 PUBCHEM_CID
3928 INN_ID
DB01108 DRUGBANK_ID
L0FPV48Q5R UNII
6850 IUPHAR_LIGAND_ID
152068 RXNORM
002119 NDDF
25142008 SNOMEDCT_US
387134000 SNOMEDCT_US

Pharmaceutical products:

None